Results 21 to 30 of about 5,737 (217)
Identification of defensin binding to C1 complement [PDF]
FEBS Letters, 1994 In human serum we found strong defensin binding to the complexes of activated C1 complement (C) and C1 inhibitor (C1i). Purified C1q, activated C1 tetramer ( 2 2) and C1i did not bind defensin. When ( 2 2) was dissociated by EDTA, only the activated C1s (Cs) bound defensin.
Panyutich, Alexander V. +4 more
openaire +2 more sources
Structure of the C1 complex of complement [PDF]
Proceedings of the National Academy of Sciences, 2017 In PNAS, Mortensen et al. (1) propose a model of the C1 complex of complement derived from small-angle X-ray scattering (SAXS) and electron microscopy (EM) analyses that contradicts previously published models and suggests an intermolecular activation process. This proposal is largely derived from a conjectural structure of C1r2C1s2, the catalytic unit
Arlaud, Gérard J +3 more
openaire +4 more sources
Design and Selection of Novel C1s Inhibitors by In Silico and In Vitro Approaches
Molecules, 2019 The complement system is associated with various diseases such as inflammation or auto-immune diseases. Complement-targeted drugs could provide novel therapeutic intervention against the above diseases.
Katalin Szilágyi +11 more
doaj +1 more source
PLoS ONE, 2020 Several candidate HIV subunit vaccines based on recombinant envelope (Env) glycoproteins have been advanced into human clinical trials. To facilitate biopharmaceutical production, it is necessary to produce these in CHO (Chinese Hamster Ovary) cells, the
Sophia W Li +7 more
doaj +1 more source
Novel scabies mite serpins inhibit the three pathways of the human complement system. [PDF]
PLoS ONE, 2012 Scabies is a parasitic infestation of the skin by the mite Sarcoptes scabiei that causes significant morbidity worldwide, in particular within socially disadvantaged populations. In order to identify mechanisms that enable the scabies mite to evade human
Angela Mika +11 more
doaj +1 more source
Current Issues in Molecular Biology, 2023 DNA methylation is an epigenetic factor that is modifiable and can change over a lifespan. While many studies have identified methylation sites (CpGs) related to aging, the relationship of these to gene function and age-related disease phenotypes remains
Thao Van Cao +5 more
doaj +1 more source
Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina
Cell Reports, 2019 Summary: Complement dysregulation is a feature of many retinal diseases, yet mechanistic understanding at the cellular level is limited. Given this knowledge gap about which retinal cells express complement, we performed single-cell RNA sequencing on ∼92,
Diana Pauly +16 more
doaj +1 more source
Clinical Case Reports, 2022 Periodontal Ehlers‐Danlos syndrome (pEDS) is a rare disorder caused by heterozygous mutations in complement 1 subunit genes C1R and C1S. To date, 148 cases have been described in the literature.We describe a case of a suspected de novo‐mutation of pEDS ...
Manfred Nilius +5 more
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundHaemostasis is a crucial process by which the body stops bleeding. It is achieved by the formation of a platelet plug, which is strengthened by formation of a fibrin mesh mediated by the coagulation cascade. In proinflammatory and prothrombotic
Murielle Golomingi +17 more
doaj +1 more source
Advanced Functional Materials, EarlyView.ABSTRACT Breathable membranes that reject chemical warfare agents (CWAs) are required for next‐generation protective apparel. A dual‐function graphene oxide (GO)‐polyamine architecture is introduced that addresses the long‐standing tradeoff between vapor transmission and CWA selectivity.
Hyungjun Kim +6 more
wiley +1 more source