Results 1 to 10 of about 11,333 (142)

Structure of human complement C8, a precursor to membrane attack.

J Mol Biol, 2011
Complement component C8 plays a pivotal role in the formation of the membrane attack complex (MAC), an important antibacterial immune effector. C8 initiates membrane penetration and coordinates MAC pore formation. High-resolution structures of C8 subunits have provided some insight into the function of the C8 heterotrimer; however, there is no ...
Bubeck D, Roversi P, Donev R, Morgan BP, Llorca O, Lea SM.   +5 more
europepmc   +7 more sources

Terminal complement complexes with or without C9 potentiate antimicrobial activity against Neisseria gonorrhoeae [PDF]

mBio
The complement cascade is a front-line defense against pathogens. Complement activation generates the membrane attack complex (MAC), a 10–11 nm diameter pore formed by complement proteins C5b through C8 and polymerized C9. The MAC embeds within the outer
Evan R. Lamb, Alison K. Criss
doaj   +2 more sources

Bactericidal membrane attack complex formation initiates at the new pole of E. coli [PDF]

EMBO Reports
Human immune protection against bacteria critically depends on activation of the complement system. The direct bacteriolytic activity of complement molecules against Gram-negative bacteria acts via the formation of Membrane Attack Complex (MAC) pores ...
Marije F L van ‘t Wout, Fabian Hauser, Philippa I P Holzapfel, Bart W Bardoel, Carla J C de Haas, Jaroslaw Jacak, Suzan H M Rooijakkers, Dani A C Heesterbeek   +7 more
doaj   +2 more sources

Complement pathway dysregulation and astrocyte alterations in Down syndrome: evidence from postmortem brain tissue and iPSC-derived astrocytes [PDF]

Acta Neuropathologica Communications
Background Down syndrome (DS), or trisomy 21 (T21), resulting from an extra copy of chromosome 21, occurs in 1 in 700–1,000 live births. Neuroinflammation is increasingly recognized as a critical contributor to DS neuropathology, although its underlying ...
André Luíz Teles e Silva, Pedro Henrique Prado de Oliveira, Bruno Yukio Yokota-Moreno, Jéssica da Silva Fausto, Jonatan Peña Avila, Helder I. Nakaya, Andréa Laurato Sertié, Bruna Lancia Zampieri   +7 more
doaj   +2 more sources

Trichinella spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Trichinella spiralis expresses paramyosin (Ts-Pmy) as a defense mechanism. Ts-Pmy is a functional protein with binding activity to human complement C8 and C9 and thus plays a role in evading the attack of the host's immune system.
Ran Sun, Xi Zhao, Zixia Wang, Jing Yang, Limei Zhao, Bin Zhan, Xinping Zhu   +6 more
doaj   +1 more source

A role for the terminal C5-C9 complement pathway in idiopathic pulmonary fibrosis

Frontiers in Medicine, 2023
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by damage to the alveolar epithelium, leading to fibrosis and excessive accumulation of extracellular matrix in the interstitium of the lung.
Liv I. B. Sikkeland, Liv I. B. Sikkeland, Thor Ueland, Thor Ueland, Thor Ueland, May B. Lund, May B. Lund, Michael Thomas Durheim, Michael Thomas Durheim, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes   +12 more
doaj   +1 more source

Novel scabies mite serpins inhibit the three pathways of the human complement system. [PDF]

PLoS ONE, 2012
Scabies is a parasitic infestation of the skin by the mite Sarcoptes scabiei that causes significant morbidity worldwide, in particular within socially disadvantaged populations. In order to identify mechanisms that enable the scabies mite to evade human
Angela Mika, Simone L Reynolds, Frida C Mohlin, Charlene Willis, Pearl M Swe, Darren A Pickering, Vanja Halilovic, Lakshmi C Wijeyewickrema, Robert N Pike, Anna M Blom, David J Kemp, Katja Fischer   +11 more
doaj   +1 more source

The oxygen carrier M101 alleviates complement activation, which may be beneficial for donor organ preservation

Frontiers in Immunology, 2022
During organ transplantation, ischemia/reperfusion injury and pre-formed anti-HLA antibodies are the main cause of delayed graft function and recovery through the activation of the complement system.
Bénédicte Puissant-Lubrano, Bénédicte Puissant-Lubrano, Charlène Bouthemy, Nicolas Congy-Jolivet, Nicolas Congy-Jolivet, Jean Milhes, Vincent Minville, Nassim Kamar, Nassim Kamar, Leïla Demini, Franck Zal, Yves Renaudineau, Yves Renaudineau   +12 more
doaj   +1 more source

Urinary complement proteins in IgA nephropathy progression from a relative quantitative proteomic analysis [PDF]

PeerJ, 2023
Aim IgA nephropathy (IgAN) is one of the leading causes of end-stage renal disease (ESRD). Urine testing is a non-invasive way to track the biomarkers used for measuring renal injury.
Xia Niu, Shuyu Zhang, Chen Shao, Zhengguang Guo, Jianqiang Wu, Jianling Tao, Ke Zheng, Wenling Ye, Guangyan Cai, Wei Sun, Mingxi Li   +10 more
doaj   +2 more sources

Combined Heterozygous Genetic Variations in Complement C2 and C8B: An Explanation for Multidimensional Immune Imbalance?

Journal of Innate Immunity, 2023
The complement system plays a crucial role in host defense, homeostasis, and tissue regeneration and bridges the innate and the adaptive immune systems. Although the genetic variants in complement C2 (c.839_849+17del; p.(Met280Asnfs*5)) and C8B (c.1625C ...
Marco Mannes, Rebecca Halbgebauer, Lisa Wohlgemuth, David Alexander Christian Messerer, Susa Savukoski, Anke Schultze, Bettina Berger, Christiane Leonie Knapp, Christoph Q. Schmidt, Daniel Fürst, Morten Hillmer, Reiner Siebert, Oskar Eriksson, Barbro Persson, Bo Nilsson, Kristina Nilsson Ekdahl, Markus Huber-Lang   +16 more
doaj   +1 more source