Results 11 to 20 of about 11,452 (258)

Interference of the Zika Virus E-Protein With the Membrane Attack Complex of the Complement System

Frontiers in Immunology, 2020
The complement system has developed different strategies to clear infections by several effector mechanisms, such as opsonization, which supports phagocytosis, attracting immune cells by C3 and C5 cleavage products, or direct killing of pathogens by the ...
Zahra Malekshahi, Britta Schiela, Sarah Bernklau, Zoltan Banki, Reinhard Würzner, Heribert Stoiber   +5 more
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Three different pathways of IgM-antibody-dependent hemolysis are mainly regulated by complement

Frontiers in Immunology, 2023
Antibodies to red blood cells (RBCs) may hemolyze erythrocytes via Fc-mediated phagocytosis or complement-dependent. Complement activation on RBCs can be detected by C3d-direct antiglobulin test (DAT), which is the only test in immune hematology that ...
Thilo Bartolmäs, Axel Pruß, Beate Mayer   +2 more
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Identity of the Segment of Human Complement C8 Recognized by Complement Regulatory Protein CD59 [PDF]

Journal of Biological Chemistry, 1995
CD59 antigen is a membrane glycoprotein that inhibits the activity of the C5b-9 membrane attack complex (MAC), thereby protecting human cells from lysis by human complement. The inhibitory function of CD59 derives from its capacity to interact with both the C8 and C9 components of MAC, preventing assembly of membrane-inserted C9 polymer. MAC-inhibitory
D H, Lockert, K M, Kaufman, C P, Chang, T, Hüsler, J M, Sodetz, P J, Sims   +5 more
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Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores.

PLoS Pathogens, 2021
Complement proteins can form membrane attack complex (MAC) pores that directly kill Gram-negative bacteria. MAC pores assemble by stepwise binding of C5b, C6, C7, C8 and finally C9, which can polymerize into a transmembrane ring of up to 18 C9 monomers ...
Dennis J Doorduijn, Dani A C Heesterbeek, Maartje Ruyken, Carla J C de Haas, Daphne A C Stapels, Piet C Aerts, Suzan H M Rooijakkers, Bart W Bardoel   +7 more
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The preparation and characterization of monoclonal antibodies to human complement component C8 and their use in purification of C8 and C8 subunits [PDF]

Biochemical Journal, 1988
1. Ten mouse monoclonal antibodies to human complement component C8 were prepared. It was found that six of these antibodies reacted with the alpha-subunit, two with the beta-subunit and two with the gamma-subunit, when assessed by immunoblotting after separation of C8 subunits by SDS/polyacrylamide-gel electrophoresis. 2.
A, Abraha, B P, Morgan, J P, Luzio
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Clinical and Genetic Spectrum of a Large Cohort With Total and Sub-total Complement Deficiencies

Frontiers in Immunology, 2019
The complement system is crucial for defense against pathogens and the removal of dying cells or immune complexes. Thus, clinical indications for possible complete complement deficiencies include, among others, recurrent mild or serious bacterial ...
Carine El Sissy, Jérémie Rosain, Paula Vieira-Martins, Pauline Bordereau, Aurélia Gruber, Magali Devriese, Loïc de Pontual, Muhamed-Kheir Taha, Claire Fieschi, Claire Fieschi, Capucine Picard, Capucine Picard, Véronique Frémeaux-Bacchi, Véronique Frémeaux-Bacchi   +13 more
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Establishing a Case for Anti-complement Therapy in Membranous Nephropathy

Kidney International Reports, 2021
Introduction: Membranous nephropathy (MN) is a common cause of adult nephrotic syndrome that progresses to end-stage kidney disease in up to 40% of cases. It is an autoimmune disease characterized by glomerular subepithelial deposits containing IgG.
Isabelle Ayoub, John P. Shapiro, Huijuan Song, Xiaolan Lily Zhang, Samir Parikh, Salem Almaani, Sethu Madhavan, Sergey V. Brodsky, Anjali Satoskar, Cherri Bott, Lianbo Yu, Michael Merchant, John Klein, Juan M. Mejia-Vilet, Tibor Nadasdy, Dan Birmingham, Brad H. Rovin   +16 more
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The effect of colostrum period management on BW and immune system in lambs: from birth to weaning

Animal, 2015
The aim of this study was to investigate the BW and immune status of lambs reared under natural conditions or under artificial conditions fed two different colostrum amounts.
L.E. Hernández-Castellano, A. Suárez-Trujillo, D. Martell-Jaizme, G. Cugno, A. Argüello, N. Castro   +5 more
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Human complement component C8

FEBS Letters, 1994
The β‐chain of human complement component C8 exhibits a structural genetic polymorphism: using isoelectric focusing two major allotypes can be identified (C8B B (‘basic’) and C8B A (‘acidic’)). In the present report we describe a sequence polymorphism of the C8B gene (codon 63: AGA → GGA) and demonstrate that the resulting amino acid substitution (Arg →
Dewald, Georg, Hemmer, Susanne, Nöthen, Markus M.   +2 more
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Trichinella spiralis paramyosin binds to C8 and C9 and protects the tissue-dwelling nematode from being attacked by host complement. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: Paramyosin is a thick myofibrillar protein found exclusively in invertebrates. Evidence suggested that paramyosin from helminths serves not only as a structural protein but also as an immunomodulatory agent.
Zhifei Zhang, Jing Yang, Junfei Wei, Yaping Yang, Xiaoqin Chen, Xi Zhao, Yuan Gu, Shijuan Cui, Xinping Zhu   +8 more
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