Results 21 to 30 of about 11,452 (258)

Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population

Frontiers in Immunology, 2018
Introduction: The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better understand complement in pathology, it is crucial to first analyze this system under ...
Mariana Gaya da Costa, Felix Poppelaars, Felix Poppelaars, Cees van Kooten, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Francesco Tedesco, Reinhard Würzner, Leendert A. Trouw, Leendert A. Trouw, Lennart Truedsson, Mohamed R. Daha, Mohamed R. Daha, Anja Roos, Marc A. Seelen   +15 more
doaj   +1 more source

Soluble Membrane Attack Complex: Biochemistry and Immunobiology

Frontiers in Immunology, 2020
The soluble membrane attack complex (sMAC, a.k.a., sC5b-9 or TCC) is generated on activation of complement and contains the complement proteins C5b, C6, C7, C8, C9 together with the regulatory proteins clusterin and/or vitronectin.
Scott R. Barnum, Doryen Bubeck, Theresa N. Schein   +2 more
doaj   +1 more source

Deficiency of the Seventh Component of Complement in a Taiwanese Boy

Journal of the Formosan Medical Association, 2006
Inherited complement deficiencies are rare, particularly those associated with late components of the complement cascade. We report a 5-year-4-month-old Taiwanese boy with systemic meningococcal infection who had undetectable CH50 level of < 6 U/mL ...
Yi-Chi Chiang, Shyh-Dar Shyur, Li-Hsin Huang, Ta-Chzng Wen, Mao-Tsair Lin, Hwai-Chih Yang, Pei-Hsuan Liang   +6 more
doaj   +1 more source

Genetic Association of the Porcine C9 Complement Component with Hemolytic Complement Activity [PDF]

Asian-Australasian Journal of Animal Sciences, 2015
The complement system is a part of the natural immune regulation mechanism against invading pathogens. Complement activation from three different pathways (classical, lectin, and alternative) leads to the formation of C5-convertase, an enzyme for ...
D. V. A. Khoa, K. Wimmers
doaj   +1 more source

Two types of dysfunctional eighth component of complement (C8) molecules in C8 deficiency in man. Reconstitution of normal C8 from the mixture of two abnormal C8 molecules. [PDF]

Journal of Clinical Investigation, 1983
Restoration of hemolytic activity was examined in sera from seven unrelated eighth component of complement (C8)-deficient subjects. The sera fell into two groups, depending on whether hemolytic activity was restored by the addition of the beta-chain (group 1) or the alpha-gamma-subunit (group 2) purified from normal human C8.
F, Tedesco, P, Densen, M A, Villa, B H, Petersen, G, Sirchia   +4 more
openaire   +2 more sources

Proteomic Analysis of Complement Proteins in Membranous Nephropathy

Kidney International Reports, 2020
Introduction: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in Caucasian adults. Phospholipase A2 receptor (PLA2R)– and exostosin 1 (EXT1)/exostosin 2 (EXT2)–associated MN represent the most common primary and secondary forms
Aishwarya Ravindran, Benjamin Madden, M. Cristine Charlesworth, Rishi Sharma, Amit Sethi, Hanna Debiec, Daniel Cattran, Fernando C. Fervenza, Richard J. Smith, Pierre Ronco, Sanjeev Sethi   +10 more
doaj   +1 more source

The Patent Ductus Arteriosus in Extremely Preterm Neonates Is More than a Hemodynamic Challenge: New Molecular Insights

Biomolecules, 2022
Complications to preterm birth are numerous, including the presence of a patent ductus arteriosus (PDA). The biological understanding of the PDA is sparse and treatment remains controversial.
Anna Sellmer, Tine Brink Henriksen, Johan Palmfeldt, Bodil Hammer Bech, Julie Astono, Tue Bjerg Bennike, Vibeke Elisabeth Hjortdal   +6 more
doaj   +1 more source

Functional Complement Analysis Can Predict Genetic Testing Results and Long-Term Outcome in Patients With Complement Deficiencies

Frontiers in Immunology, 2018
BackgroundPrevalence of complement deficiencies (CDs) is markedly higher in Slovenian primary immunodeficiency (PID) registry in comparison to other national and international PID registries.ObjectiveThe purposes of our study were to confirm CD and ...
Štefan Blazina, Maruša Debeljak, Mitja Košnik, Mitja Košnik, Saša Simčič, Sanja Stopinšek, Gašper Markelj, Nataša Toplak, Nataša Toplak, Peter Kopač, Breda Zakotnik, Marko Pokorn, Tadej Avčin, Tadej Avčin   +13 more
doaj   +1 more source

Novel mechanisms of immune evasion by Schistosoma mansoni

Memorias do Instituto Oswaldo Cruz, 1995
The interaction of Schistosoma mansoni with its host's immune system is largely affected by multiple specific and non-specific evasion mechanisms employed by the parasite to reduce the host's immune reactivity. Only little is known about these mechanisms
Zvi Fishelson
doaj   +1 more source

Comparative Analysis of Serum Proteins Between Hepatitis B Virus Genotypes B and C Infection by DIA-Based Quantitative Proteomics

Infection and Drug Resistance, 2021
Yunqing Chen,1,2 Dahai Wei,1– 3 Min Deng1– 3 1Department of Infectious Diseases, Affiliated Hospital of Jiaxing University, Jiaxing, People’s Republic of China; 2Department of Infectious Diseases, First Hospital of Jiaxing, Jiaxing, People’s Republic of ...
Chen Y, Wei D, Deng M
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