Predatory and Defensive Strategies in Cone Snails
ToxinsCone snails are carnivorous marine animals that prey on fish (piscivorous), worms (vermivorous), or other mollusks (molluscivorous). They produce a complex venom mostly made of disulfide-rich conotoxins and conopeptides in a compartmentalized venom gland.
Zahrmina Ratibou +2 more
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Screening and Validation of Highly-Efficient Insecticidal Conotoxins from a Transcriptome-Based Dataset of Chinese Tubular Cone Snail [PDF]
Toxins, 2017 Most previous studies have focused on analgesic and anti-cancer activities for the conotoxins identified from piscivorous and molluscivorous cone snails, but little attention has been devoted to insecticidal activity of conotoxins from the dominant ...
Bingmiao Gao +5 more
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Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor [PDF]
eLife, 2019 The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins G1, has unique characteristics relevant to the design of new insulin ...
Peter Ahorukomeye +13 more
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Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails [PDF]
Marine Drugs, 2018 Marine cone snails are a large family of gastropods that have evolved highly potent venoms for predation and defense. The cone snail venom has exceptional molecular diversity in neuropharmacologically active compounds, targeting a range of receptors, ion
Nikita Abraham, Richard J. Lewis
doaj +4 more sources
Venom Diversity and Evolution in the Most Divergent Cone Snail Genus Profundiconus [PDF]
Toxins, 2019 Profundiconus is the most divergent cone snail genus and its unique phylogenetic position, sister to the rest of the family Conidae, makes it a key taxon for examining venom evolution and diversity. Venom gland and foot transcriptomes of Profundiconus cf.
Giulia Fassio +8 more
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Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis [PDF]
Marine Drugs, 2019 Individual variation in animal venom has been linked to geographical location, feeding habit, season, size, and gender. Uniquely, cone snails possess the remarkable ability to change venom composition in response to predatory or defensive stimuli.
Ai-Hua Jin +6 more
doaj +2 more sources
Mitochondrial genome sequencing of a vermivorous cone snail Conus quercinus supports the correlative analysis between phylogenetic relationships and dietary types of Conus species. [PDF]
PLoS ONE, 2018 Complete mitochondrial genome (mitogenome) sequence of a worm-hunting cone snail, Conus quercinus, was reported in this study. Its mitogenome, the longest one (16,460 bp) among reported Conus specie, is composed of 13 protein-coding genes (PCGs), 22 ...
Bingmiao Gao +4 more
doaj +2 more sources
Venom variation during prey capture by the cone snail, Conus textile. [PDF]
PLoS ONE, 2014 Observations of the mollusc-hunting cone snail Conus textile during feeding reveal that prey are often stung multiple times in succession. While studies on the venom peptides injected by fish-hunting cone snails have become common, these approaches have ...
Cecilia A Prator +2 more
doaj +2 more sources
Cysteine pattern barcoding-based dataset filtration enhances the machine learning-assisted interpretation of Conus venom peptide therapeutics. [PDF]
PLoS ONECrude cone snail venom is a rich source of bioactive compounds with significant therapeutic potential. In this study, we conducted a comprehensive analysis of 5,985 cone snail peptides across 82 Conus species to identify unique cysteine (Cys) patterns ...
Rimsha Bibi, Noshaba Qasmi, Sajid Rashid
doaj +2 more sources
Dynamin‐Related Protein 1‐Dependent Disruption of Mitochondrial Homeostasis Drives Blue Light‐Induced Epithelial‐Mesenchymal Transition in Retinal Aging [PDF]
Aging CellBlue light causes retinal injury by inducing excessive mitochondrial fission and epithelial‐mesenchymal transition in retinal pigment epithelial cells. Therapeutic targeting of Drp1 rescues this damage, restoring mitochondrial homeostasis and retinal integrity.
Li Z +5 more
europepmc +2 more sources