Results 111 to 120 of about 1,314 (159)

Computational exploration of global venoms for antimicrobial discovery with Venomics artificial intelligence. [PDF]

Nat Commun
Guan C, Torres MDT, Li S, de la Fuente-Nunez C.   +3 more
europepmc   +1 more source

Redox-Active Conopeptide Li520 Has Evolved to Catalyze Oxidative Folding of Conotoxins. [PDF]

ACS Omega
Dhannura S, Shekh S, Dhurjad P, Dolle A, Kakkat S, Vishwajyothi, Vijayasarathy M, Sonti R, Gowd KH.   +8 more
europepmc   +1 more source

Spider venom peptides with unique fold selectively block Shaker-type potassium channels. [PDF]

Cell Mol Life Sci
Kuzmenkov AI, Iunusova VA, Lushpa VA, Deyev YA, Babenko VV, Osipov DV, Berkut AA, Tytgat J, Bocharov EV, Adams DJ, Finol-Urdaneta RK, Vassilevski AA.   +11 more
europepmc   +1 more source

Fish-hunting cone snail disrupts prey's glucose homeostasis with weaponized mimetics of somatostatin and insulin. [PDF]

Nat Commun
Yeung HY, Ramiro IBL, Andersen DB, Koch TL, Hamilton A, Bjørn-Yoshimoto WE, Espino S, Vakhrushev SY, Pedersen KB, de Haan N, Hipgrave Ederveen AL, Olivera BM, Knudsen JG, Bräuner-Osborne H, Schjoldager KT, Holst JJ, Safavi-Hemami H.   +16 more
europepmc   +1 more source

Peptides from Animal Venoms: A Promising Frontier in Diabetes Therapy via Multi-Target Mechanisms. [PDF]

Pharmaceuticals (Basel)
de Almeida JOCS, Comerma-Steffensen SG, de Souza de Almeida Leite JR, Simonsen U, Arcanjo DDR.   +4 more
europepmc   +1 more source

Exploring the Pain-Relieving Potential: Unveiling Antinociceptive Properties in Animal Venoms and Toxins. [PDF]

Toxins (Basel)
Angstmam DG, Jeronimo BC, Cavalcante JDS, Pereira AFM, Villarreal CF, Pimenta DC, Ferreira Junior RS.   +6 more
europepmc   +1 more source

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Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides)

Current Topics in Medicinal Chemistry, 2012
Cone snails have evolved many 1000s of small, structurally stable venom peptides (conopeptides) for prey capture and defense. Whilst < 0.1% have been pharmacologically characterised, those with known function typically target membrane proteins of therapeutic importance, including ion channels, transporters and GPCRs. Several conopeptides reduce pain in
Vetter, Irina, Lewis, Richard J.
openaire   +3 more sources

Ichthyotoxicity caused by marine cone snail venoms?

Toxicon, 2005
Ten venoms from marine cone snails were tested for ichthyotoxic effects on zebra fish (Brachydanio rerio) when added to the water. Only two venoms, from Conus capitaneus and Conus episcopatus, produced lethal effects at high concentrations (50-300 microg/ml) within 20-90 min. No sedative or hypnotic symptoms were observed.
Dietrich, Mebs, Silke, Kauferstein
openaire   +2 more sources

Cone Snail Venomics: From Novel Biology to Novel Therapeutics

Future Medicinal Chemistry, 2014
Peptide neurotoxins from cone snails called conotoxins are renowned for their therapeutic potential to treat pain and several neurodegenerative diseases. Inefficient assay-guided discovery methods have been replaced by high-throughput bioassays integrated with advanced MS and next-generation sequencing, ushering in the era of 'venomics'. In this review,
Prashanth, Jutty Rajan, Brust, Andreas, Jin, Ai-Hua, Alewood, Paul F., Dutertre, Sebastien, Lewis, Richard J.   +5 more
openaire   +3 more sources