Results 121 to 130 of about 1,314 (159)

Neurotoxins of Cone Snail Venoms

2002
Cone snails are predatory marine mollusks that rely on their venom components to immobilize and capture fish, worms, or other mollusks. Cones employ a number of prey-hunting strategies, ultimately involving the injection of venom through a hollow, harpoon-like, modified-tooth structure (1).
Robert Newcomb, George Miljanich
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Venomic study on cone snails (Conus spp.) from South Africa

Toxicon, 2011
From six Conus species (Conus coronatus, Conus lividus, Conus mozambicus f. lautus, Conus pictus, Conus sazanka, Conus tinianus) collected off the eastern coast of South Africa the venoms were analyzed using MALDI-TOF mass spectrometry. Between 56 and 151 molecular masses most in a range of 1000 to 2500 Da, were identified.
Kauferstein, S., Porth, C., Kendel, Y., Wunder, C., Nicke, A., Kordis, D., Favreau, P., Koua, D., Stoecklin, R., Mebs, D.   +9 more
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Structural and biosynthetic properties of peptides in cone snail venoms

Peptides, 1995
Venoms of the predatory cone snails Conus textile, Conus striatus, and Conus magus were subjected to comprehensive analysis of peptide content. With the fish-eating cone snails C. magus and C. striatus, the most abundant venom peptides were of > 30-50 residues, whereas the predominant peptides in the venom of the mollusc-eating snail, C.
R, Newcomb, S, Gaur, J R, Bell, L, Cruz
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Pharmacology of predatory and defensive venom peptides in cone snails

Molecular BioSystems, 2017
Cone snails use distinct venoms for defence and prey capture. The pharmacology of these neurotoxic peptides have been extensively studied for pharmacological probes, venom evolution mechanisms and potential therapeutics.
Jutty Rajan Prashanth, Sebastien Dutertre, Richard James Lewis   +2 more
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Phyla Molluska: The Venom Apparatus of Cone Snails

2015
Predatory marine gastropods of the genus Conus comprise similar to 700 species that have evolved a highly specialized envenomation apparatus. This recently evolved genus has developed potent venoms separately for prey capture and defense. Both strategies utilize a complex but different cocktail of venom peptides that is injected through a hollow ...
Dutertre, Sebastien, Griffin, John, Lewis, Richard J.   +2 more
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Venomous cone snails: molecular phylogeny and the generation of toxin diversity

Toxicon, 2001
In order to investigate the generation of conotoxin diversity, delta-conotoxin sequences from nine Conus species were analyzed in the context of their phylogeny. Using a standard molecular marker, mitochondrial 16S RNA, we determined that the delta-conotoxins were derived from three distinct species clades based on the phylogenetic reconstruction of a ...
D J, Espiritu, M, Watkins, V, Dia-Monje, G E, Cartier, L J, Cruz, B M, Olivera   +5 more
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Combinatorial peptide libraries in drug design: lessons from venomous cone snails

Trends in Biotechnology, 1995
Many present-day drugs are derived from compounds that are natural products, a traditional source of which is fermentation broths of microorganisms. The venoms of cone snails are a new natural resource of peptides that may have a pharmaceutical potential equivalent to those from traditional sources, particularly for developing drugs that target cell ...
B M, Olivera, D R, Hillyard, M, Marsh, D, Yoshikami   +3 more
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Uncovering Intense Protein Diversification in a Cone Snail Venom Gland Using an Integrative Venomics Approach

Journal of Proteome Research, 2015
Marine cone snail venoms are highly complex mixtures of peptides and proteins. They have been studied in-depth over the past 3 decades, but the modus operandi of the venomous apparatus still remains unclear. Using the fish-hunting Conus consors as a model, we present an integrative venomics approach, based on new proteomic results from the venom gland ...
Daniel, Biass, Aude, Violette, Nicolas, Hulo, Frédérique, Lisacek, Philippe, Favreau, Reto, Stöcklin   +5 more
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Intraspecific variation in the venom of the vermivorous cone snail Conus vexillum

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2011
A combination of proteomic and biochemical assays was used to examine variations in the venom of Conus vexillum taken from two locations (Hurgada and Sharm El-Shaikh) in the Red Sea, Egypt. Using MALDI/TOF-MS, a remarkable degree of intra-species variation between venom samples from both locations was identified.
Mohamed A, Abdel-Rahman, Ismail M, Abdel-Nabi, Mohamed S, El-Naggar, Osama A, Abbas, Peter N, Strong   +4 more
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HYBRID ECMO AND CONE SNAIL VENOM POISONING

Journal of the American College of Cardiology, 2022
Renato C. Ong, Maria Stephanie Alessa Florentino, Raul Lapitan   +2 more
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