Results 81 to 90 of about 1,314 (159)

Screening and Validation of Highly-Efficient Insecticidal Conotoxins from a Transcriptome-Based Dataset of Chinese Tubular Cone Snail

Toxins, 2017
Most previous studies have focused on analgesic and anti-cancer activities for the conotoxins identified from piscivorous and molluscivorous cone snails, but little attention has been devoted to insecticidal activity of conotoxins from the dominant ...
Bingmiao Gao, Chao Peng, Bo Lin, Qin Chen, Junqing Zhang, Qiong Shi   +5 more
doaj   +1 more source

Structural information in therapeutic peptides: Emerging applications in biomedicine

FEBS Open Bio, Volume 15, Issue 2, Page 254-268, February 2025.
Peptides are increasingly popular as therapeutic agents due to their cost‐effectiveness, low immune response, and high specificity. Many tools study peptides as linear chains, ignoring crucial structural details that affect their properties. Recent advances in peptide structure prediction have improved our understanding.
Valentín Iglesias, Oriol Bárcenas, Carlos Pintado‐Grima, Michał Burdukiewicz, Salvador Ventura   +4 more
wiley   +1 more source

Glycosylation of Conotoxins

Marine Drugs, 2013
Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools ...
Rolf Boelens, Johannis P. Kamerling, Reto Stöcklin, Henry G. Hocking, Gerrit J. Gerwig   +4 more
doaj   +1 more source

Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp.

Marine Drugs, 2016
Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of ...
Eline K. M. Lebbe, Maarten G. K. Ghequire, Steve Peigneur, Bea G. Mille, Prabha Devi, Samuthirapandian Ravichandran, Etienne Waelkens, Lisette D’Souza, René De Mot, Jan Tytgat   +9 more
doaj   +1 more source

Biodiversity2Drugs—Renaissance of exploring nature‐derived peptides for GPCR ligand discovery

British Journal of Pharmacology, Volume 182, Issue 16, Page 3691-3694, August 2025.
Christian W. Gruber, Isabel Beets, Pierre‐Luc Boudreault, Vanderlan da S. Bolzani, Jens Carlsson, Pedro A. Fernandes, Michael Freissmuth, Nicolas Gilles, Ulf Göransson, Alexander S. Hauser, Christian Heinis, Jeroen Kool, William D. Lubell, Maria Vittoria Modica, Jana Selent, Jan Tytgat, Eivind A. B. Undheim, The Biodiversity2Drugs Consortium, Christian W. Gruber, Michael Freissmuth, Nicolas Gilles, Marion Chaigneau, Xavier Iturrioz, Pascal Kessler, Philippe Robin, Isabel Beets, Eivind A. B. Undheim, Jeroen Kool, Rob Leurs, Henry Vischer, Jan Tytgat, Steve Peigneur, Kathleen Carleer, Vanderlan da S. Bolzani, Ana Leticia Piros, William Lubell, Pierre‐Luc Boudreault, Alexander S. Hauser, Luuk R. Hoegen Dijkhof, Teemu K. E. Rönkkö, Maria Vittoria Modica, Serena Leone, Giovanna Ponte, Pedro Fernandes, Maria Joao Ramos, Jana Selent, Elizaveta Korchevaya, Tomasz Stepniewski, Jens Carlsson, Israel Cabeza de Vaca, Ulf Göransson, Sunithi Gunasekera, Erik Jacobsson, Christian Heinis, Tao Che, Maurice R. Elphick, Peter J. McCormick, Samuel Robinson, Helena Safavi‐Hemami, Roderich D. Süssmuth, Axel Touchard, Wilfred A. van der Donk, Denise Wootten, Julius Hermes, Johannes Schneider, Ana Leticia Pires, Marin Matic, António J. M. Ribeiro, João Sousa, Joana Ribeiro da Silva, Lauri Urvas, Arun Shukla   +71 more
wiley   +1 more source

Characterization of the Conus bullatus genome and its venom-duct transcriptome

BMC Genomics, 2011
Background The venomous marine gastropods, cone snails (genus Conus), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high affinity for its molecular target, generally an ion channel, receptor or transporter.
Olivera Baldomero M, Bandyopadhyay Pradip K, Hu Hao, Yandell Mark   +3 more
doaj   +1 more source

ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential

Marine Drugs, 2006
: Highly selective N-type voltage-gated calcium (CaV) channel inhibitors from cone snail venom (the ω-conotoxins) have emerged as a new class of therapeutics for the treatment of chronic and neuropathic pain.
Richard J. Lewis, Christina I. Schroeder
doaj   +1 more source

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles. [PDF]

Nat Struct Mol Biol, 2020
Xiong X, Menting JG, Disotuar MM, Smith NA, Delaine CA, Ghabash G, Agrawal R, Wang X, He X, Fisher SJ, MacRaild CA, Norton RS, Gajewiak J, Forbes BE, Smith BJ, Safavi-Hemami H, Olivera B, Lawrence MC, Chou DH.   +18 more
europepmc   +1 more source

Venom Apparatus Structure and Conutoxins Granules formation in Cone Snail (Conus coronatus) of Persian Gulf

Iranian South Medical Journal, 2014
Background: Today use conotoxin as a neurotoxin and cytotoxin in medical science is obvious. These compounds are produced by venomous cone snails. Toxins produced by the venom apparatus of this snail and injected into the prey.
Ferial Monsef, Saber Khodabandeh, Iraj Nabipour   +2 more
doaj  

Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom. [PDF]

J Proteomics, 2015
Robinson SD, Safavi-Hemami H, Raghuraman S, Imperial JS, Papenfuss AT, Teichert RW, Purcell AW, Olivera BM, Norton RS.   +8 more
europepmc   +1 more source