Results 31 to 40 of about 1,281 (179)

Conformational Heterogeneity of Pro-Pro Containing 23-Membered Ring Conopeptides by NMR. [PDF]

ACS Omega
Dhurjad P, Dannarm SR, Shaik K, Wanjari P, Sonti R.   +4 more
europepmc   +2 more sources

Identification of Novel Conopeptides and Distinct Gene Superfamilies in the Marine Cone Snail Conus quercinus

Frontiers in Marine Science, 2021
Conopeptides from the marine cone snails are a mixture of cysteine-rich active peptides, representing a unique and fertile resource for neuroscience research and drug discovery.
Han Zhang, Han Zhang, Han Zhang, Lei Wang, Xiang Yang, Xiang Yang, Xiang Yang, Zhiwei Lian, Zhiwei Lian, Yinbin Qiu, Yinbin Qiu, Zhanying Dong, Zhanying Dong, Xuedong Wu, Xuedong Wu, Xinghua Pan, Xinghua Pan, Xinghua Pan, Xinghua Pan   +18 more
doaj   +1 more source

Discovery of 194 Unreported Conopeptides and Identification of a New Protein Disulfide Isomerase in Conus caracteristicus Using Integrated Transcriptomic and Proteomic Analysis

Frontiers in Marine Science, 2022
Current ConoServer database accumulates 8,134 conopeptides from 122 species of cone snail, which are pharmaceutically attractive marine resource. However, many more conopeptides remain to be discovered, and the enzymes involved in their synthesis and ...
Han Zhang, Han Zhang, Han Zhang, Lei Wang, Yinbin Qiu, Yinbin Qiu, Yinbin Qiu, Fahui Gong, Baoting Nong, Xinghua Pan, Xinghua Pan, Xinghua Pan   +11 more
doaj   +1 more source

Cupryphans, metal‐binding, redox‐active, redesigned conopeptides [PDF]

Protein Science, 2009
AbstractContryphans are bioactive peptides, isolated from the venom of marine snails of the genus Conus, which are characterized by the short length of the polypeptide chain and the high degree of unusual post‐translational modifications. The cyclization of the polypeptide chain through a single disulphide bond, the presence of two conserved Pro ...
BARBA, MARCO, A. P. SOBOLEV, C. ROMEO, SCHININA', Maria Eugenia, D. PIETRAFORTE, MANNINA, LUISA, G. MUSCI, F. POLTICELLI   +7 more
openaire   +6 more sources

Side‐chain dynamics of the α1B‐adrenergic receptor determined by NMR via methyl relaxation

Protein Science, Volume 32, Issue 11, November 2023., 2023
Abstract G protein‐coupled receptors (GPCRs) are medically important membrane proteins that sample inactive, intermediate, and active conformational states characterized by relatively slow interconversions (~μs–ms). On a faster timescale (~ps–ns), the conformational landscape of GPCRs is governed by the rapid dynamics of amino acid side chains.
Christian Baumann, Wan‐Chin Chiang, Renato Valsecchi, Simon Jurt, Mattia Deluigi, Matthias Schuster, Karl Johan Rosengren, Andreas Plückthun, Oliver Zerbe   +8 more
wiley   +1 more source

Isolation and structural identification of a new T1-conotoxin with unique disulfide connectivities derived from Conus bandanus [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2020
Background: Conopeptides are neuropharmacological peptides derived from the venomous salivary glands of cone snails. Among 29 superfamilies based on conserved signal sequences, T-superfamily conotoxins, which belong to the smallest group, include four ...
Nguyen Bao, Jean-Pière Lecaer, Ngo Dang Nghia, Phan Thi Khanh Vinh   +3 more
doaj   +1 more source

High‐resolution crystal structure of the Mu8.1 conotoxin from Conus mucronatus

Acta Crystallographica Section F, Volume 79, Issue 9, Page 240-246, September 2023., 2023
The crystal structure of the Mu8.1 conotoxin was determined in the high‐symmetry space group I4122 at 1.67 Å resolution. This crystal structure reveals a surface‐exposed Zn2+‐binding site and establishes a hydrogen‐bonding network around Lys55 buried at the dimer interface.Marine cone snails produce a wealth of peptide toxins (conotoxins) that bind ...
Emilie Müller, Celeste Menuet Hackney, Lars Ellgaard, Jens Preben Morth   +3 more
wiley   +1 more source

Hormone-like conopeptides - new tools for pharmaceutical design. [PDF]

RSC Med Chem, 2020
Marine cone snails produce an array of hormone-like peptides in their venom, providing bioactive leads for developing peptide drugs and small molecule mimetics.
Turner A, Kaas Q, Craik DJ.
europepmc   +5 more sources

Non-Peptidic Small Molecule Components from Cone Snail Venoms

Frontiers in Pharmacology, 2021
Venomous molluscs (Superfamily Conoidea) comprise a substantial fraction of tropical marine biodiversity (>15,000 species). Prior characterization of cone snail venoms established that bioactive venom components used to capture prey, defend against ...
Zhenjian Lin, Joshua P. Torres, Maren Watkins, Noemi Paguigan, Changshan Niu, Julita S. Imperial, Jortan Tun, Helena Safavi-Hemami, Helena Safavi-Hemami, Rocio K. Finol-Urdaneta, Jorge L. B. Neves, Samuel Espino, Manju Karthikeyan, Baldomero M. Olivera, Eric W. Schmidt   +14 more
doaj   +1 more source

Tyrosine-rich Conopeptides Affect Voltage-gated K+ Channels [PDF]

Journal of Biological Chemistry, 2008
Two venom peptides, CPY-Pl1 (EU000528) and CPY-Fe1 (EU000529), characterized from the vermivorous marine snails Conus planorbis and Conus ferrugineus, define a new class of conopeptides, the conopeptide Y (CPY) family. The peptides have no disulfide cross-links and are 30 amino acids long; the high content of tyrosine is unprecedented for any native ...
Imperial, Julita S., Chen, Ping, Sporning, Annett, Terlau, Heinrich, Daly, Norelle L., Craik, David J., Alewood, Paul F., Olivera, Baldormero M.   +7 more
openaire   +4 more sources