Results 61 to 70 of about 1,281 (179)
Allosteric α1-Adrenoreceptor Antagonism by the Conopeptide ρ-TIA [PDF]
Journal of Biological Chemistry, 2003 A peptide contained in the venom of the predatory marine snail Conus tulipa, rho-TIA, has previously been shown to possess alpha1-adrenoreceptor antagonist activity. Here, we further characterize its pharmacological activity as well as its structure-activity relationships.
Sharpe, Iain A. +11 more
openaire +3 more sources
Current and Future Issues in the Development of Spinal Agents for the Management of Pain. [PDF]
, 2017 Targeting analgesic drugs for spinal delivery reflects the fact that while the conscious experience of pain is mediated supraspinally, input initiated by high intensity stimuli, tissue injury and/or nerve injury is encoded at the level of the spinal ...
Fisher, Casey J +3 more
core +2 more sources
International Journal of Peptides, Volume 2013, Issue 1, 2013., 2013 Conus venoms are rich sources of biologically active peptides that act specifically on ionic channels and metabotropic receptors present at the neuromuscular junction, efficiently paralyzing the prey. Each species of Conus may have 50 to 200 uncharacterized bioactive peptides with pharmacological interest.
Maria Cristina Vianna Braga +6 more
wiley +1 more source
Inventory and Distribution of Mollusc in Coral Reef of Bacan Island Waters, North Maluku Province [PDF]
, 2017 Bacan Island waters of North Maluku Province consisted of three main tropical ecosystems, namely mangrove, seagrass, and coral reef with the highest marine biodiversity.
Cappenberg, H. A. (Hendrik)
core +3 more sources
Overexpression, purification, and pharmacological activity of a biosynthetically derived conopeptide [PDF]
Biochemical and Biophysical Research Communications, 2005 A high yielding fusion protein system based on the protein cytochrome b(5) has been used for the production of novel 13-residue acyclic conopeptide. This peptide, Mo1659, can be liberated from the carrier protein using CNBr cleavage and subsequent purification using RP-HPLC methods. The yield of isotopically enriched peptides is high, ranging from 3 to
Kumar, Ganesan Senthil +3 more
openaire +3 more sources
A Benchmark Dataset Comprising Partition and Distribution Coefficients of Linear Peptides
Dataset Papers in Science, Volume 2013, Issue 1, 2013., 2013 Peptides have a dominant role in biology; yet the study of their physical properties is at best sporadic. Peptide quantitative structure‐activity relationship (QSAR) lags far behind the QSAR analysis of drug‐like organic small molecules. Traditionally, QSAR has focussed on experimentally determined partition coefficients as the main descriptor of ...
Matthew N. Davies +3 more
wiley +1 more source
Les canaux calciques dépendants du voltage au coeur de la douleur [PDF]
, 2006 Les canaux calciques dépendants du voltage représentent une des voies principales d’entrée du calcium dans la cellule nerveuse où ils participent activement à l’excitabilité cellulaire et aux processus moléculaires de la transmission synaptique. Ils ont,
De Waard, Michel, Weiss, Norbert
core +1 more source
British Journal of Pharmacology, Volume 182, Issue 3, Page 564-580, February 2025.Abstract Background and Purpose Botulinum neurotoxin type A1 (BoNT/A) is one of the most potent neurotoxins known. At the same time, it is also one of the safest therapeutic agents used for the treatment of several human disorders and in aesthetic medicine.
Mickaël Machicoane +9 more
wiley +1 more source
[Retracted] A Showcase of Bench‐to‐Bedside Regenerative Medicine at the 2010 ASNTR
The Scientific World Journal, Volume 11, Issue 1, Page 1842-1864, 2011., 2011 Insight into the expanding themes of regenerative medicine is provided by the American Society for Neural Therapy and Repair′s annual meeting. The 17th meeting covered a wide range of neurodegenerative disorders, exploring methods to elucidate the currently unknown mechanisms behind the disorders, as well as possible treatments ranging from the use of ...
David J. Eve +3 more
wiley +1 more source
DESM: portal for microbial knowledge exploration systems [PDF]
, 2015 Microorganisms produce an enormous variety of chemical compounds. It is of general interest for mi-crobiology and biotechnology researchers to have means to explore information about molecular and genetic basis of functioning of different microor-ganisms
Adil Salhi +22 more
core +1 more source