Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery
Toxins, 2017 Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than 700 species, have always been one of the focuses for new drug discovery.
Bingmiao Gao +5 more
doaj +1 more source
The FASEB Journal, Volume 38, Issue 1, 15 January 2024.Analogs of α‐conotoxin PnIC selectively inhibit α7β2‐ over α7‐only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism.Andrew A. George, Sabin J. John, Linda M. Lucero, J. Brek Eaton, Ekta Jaiswal, Sean B. Christensen, Joanna Gajewiak, Maren Watkins, Yiwei Cao, Baldomero M. Olivera, Wonpil Im, J.
Andrew A. George +12 more
wiley +1 more source
NMR structure of μ-conotoxin GIIIC : leucine 18 induces local repacking of the N-terminus resulting in reduced NaV channel potency [PDF]
, 2018 mu-Conotoxins are potent and highly specific peptide blockers of voltage-gated sodium channels. In this study, the solution structure of mu-conotoxin GIIIC was determined using 2D NMR spectroscopy and simulated annealing calculations.
Adams, David J +9 more
core +1 more source
Characterisation of a Novel A-Superfamily Conotoxin
Biomedicines, 2020 Conopeptides belonging to the A-superfamily from the venomous molluscs, Conus, are typically α-conotoxins. The α-conotoxins are of interest as therapeutic leads and pharmacological tools due to their selectivity and potency at nicotinic acetylcholine ...
David T. Wilson +6 more
doaj +1 more source
DNA barcoding of seven cone snail species from Red Sea coast of Egypt
Egyptian Journal of Aquatic Research, 2021 Cone snails are venomous predators comprising ~950 species widely distributed in different marine habitats. The production of bioactive molecules (known as conopeptides or conotoxins) marks the Conus as an utmost promising animal source for medicinal ...
Moustafa Sarhan +3 more
doaj +1 more source
Conotoxins: structure, therapeutic potential and pharmacological applications. [PDF]
, 2016 Cone snails, also known as marine gastropods, from Conus genus produce in their venom a diverse range of small pharmacologically active structured peptides called conotoxins.
Kamal, M. +9 more
core +2 more sources
Frontiers in Pharmacology, 2019 Venomous marine snails of the genus Conus employ small peptides to capture prey, mainly osteichthyes, mollusks, and worms. A subset of these peptides known as α-conotoxins, are antagonists of nicotinic acetylcholine receptors (nAChRs).
Veronika Grau +5 more
doaj +1 more source
Analgesic alpha-Conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABA-B receptor activation [PDF]
, 2008 alpha-Conotoxins Vc1.1 and Rg1A are peptides from the venom of marine Conus snails that are currently in development as a treatment for neuropathic pain. Here we report that the alpha 9 alpha 10 nicotinic acetylcholine receptor-selective conotoxins Vc1.1
Adams, David J. +5 more
core +2 more sources
Synthesis, Pharmacological and Structural Characterization of Novel Conopressins from Conus miliaris
Marine Drugs, 2020 Cone snails produce a fast-acting and often paralyzing venom, largely dominated by disulfide-rich conotoxins targeting ion channels. Although disulfide-poor conopeptides are usually minor components of cone snail venoms, their ability to target key ...
Julien Giribaldi +7 more
doaj +1 more source
Florida marine biotechnology: research, development and training capabilities to advance science and commerce [PDF]
, 2001 The level of activity and interest in “marine biotechnology” among Florida university faculty and allied laboratory scientists is reported in this document.
Seaman, William +1 more
core