Cuproptosis-associated lncRNAs discern prognosis and immune microenvironment in sarcoma victims [PDF]
Frontiers in Cell and Developmental Biology, 2022 Cuproptosis is a fresh form of the copper-elesclomol-triggered, mitochondrial tricarboxylic acid (TCA) dependent cell death. Yet, the subsumed mechanism of cuproptosis-associated lncRNAs in carcinoma is not wholly clarified.
Binxiang Chu +4 more
doaj +3 more sources
The molecular mechanism of cuproptosis and research progress in pancreatic diseases [PDF]
Annals of MedicinePurpose Cuproptosis has been proven to be a novel mode of cell death, distinct from other types of cell death such as necrosis, ferroptosis, pyroptosis, and apoptosis.
Qizhi Wang +6 more
doaj +2 more sources
DACT1 inhibits cuproptosis and promotes cell malignancy via activation of PI3K/AKT signaling in laryngeal squamous cell carcinoma [PDF]
European Journal of Medical ResearchBackground Laryngeal cancer has one of the highest mortality rates of all head and neck cancers. DACT1 is a cuproptosis-related gene in laryngeal cancer and serves as a risk factor for patient prognosis.
Yan Guo +5 more
doaj +2 more sources
Cuproptosis in stroke: focusing on pathogenesis and treatment [PDF]
Frontiers in Molecular NeuroscienceAnnually, more than 15 million people worldwide suffer from stroke, a condition linked to high mortality and disability rates. This disease significantly affects daily life, impairing everyday functioning, executive function, and cognition.
Liwei Xing +5 more
doaj +3 more sources
Distinct cuproptosis patterns in hepatocellular carcinoma patients correlate with unique immune microenvironment characteristics and cell-cell communication, contributing to varied overall survival outcomes [PDF]
Frontiers in ImmunologyBackgroundHepatocellular carcinoma (HCC), a prevalent cancer, is linked to cuproptosis in tumor progression. However, cuproptosis's impact on HCC prognosis and its role in the tumor microenvironment remain unclear.
Yanhong Wang +5 more
doaj +3 more sources
Molecular subtypes, tumor microenvironment infiltration characterization and prognosis model based on cuproptosis in bladder cancer [PDF]
PeerJ, 2023 Cuproptosis is a kind of cell death dependent on copper. We aimed to explore the functions of the cuproptosis in the tumor microenvironment (TME) and construct a cuproptosis-related prognosis signature in bladder cancer (BCa).
Heping Zhang, Ji Liu, Zongtai Zheng
doaj +2 more sources
Frontiers in Genetics, 2022 Objectives: Bladder cancer (BLCA) is the most common malignant tumor in the urinary system, while the prognosis of muscle-invasive bladder cancer (MIBC) is poor. Cuproptosis might be a promising therapeutic approach to trigger tumor cell death.
Shun Zhang +5 more
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundOsteoarthritis (OA) is a prevalent chronic joint disease with an obscure underlying molecular signature. Cuproptosis plays a crucial role in various biological processes.
Jiao Nong +6 more
doaj +1 more source
Pan‐cancer analyses reveal molecular and clinical characteristics of cuproptosis regulators
iMeta, 2023 Imbalance in copper homeostasis can be lethal. A recent study found that excess copper induces cell death in a way that has never been characterized before, which is dependent on mitochondrial stress and is referred to as “cuproptosis.” The role of ...
Changwu Wu +7 more
doaj +1 more source
Frontiers in Oncology, 2022 BackgroundCuproptosis, a recently discovered refreshing form of cell death, is distinct from other known mechanisms. As copper participates in cell death, the induction of cancer cell death with copper ionophores may emerge as a new avenue for cancer ...
Wei Li +4 more
doaj +1 more source