Results 11 to 20 of about 7,425 (214)
Cuproptosis in osteoarthritis: Exploring chondrocyte cuproptosis and therapeutic avenues
Journal of Orthopaedic TranslationBackground: Cuproptosis, a newly identified form of cell death, presents an as-yet-unclear potential correlation with Osteoarthritis (OA) pathogenesis. This study aimed to explore the relationship between chondrocyte cuproptosis and OA, and to evaluate ...
Haotian Hua +9 more
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Recent progress of methods for cuproptosis detection
Frontiers in Molecular BiosciencesVarying from other identified cell death pathways, cuproptosis is a new type of regulated cell death characterized by excess Cu ions, abnormal aggregation of lipoylated proteins in TCA cycle, loss of Fe-S cluster proteins, upregulation of HSP70, leading ...
Ligang Zhang +11 more
doaj +3 more sources
Small StructuresCuproptosis, a recently identified copper‐dependent metabolic cell death pathway, eliminates tumor cell via toxic aggregation of lipoylated enzymes in the tricarboxylic acid cycle.
Hao Zhou +8 more
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Novel insights into cuproptosis inducers and inhibitors
Frontiers in Molecular BiosciencesCuproptosis is a new pattern of Cu-dependent cell death distinct from classic cell death pathways and characterized by aberrant lipoylated protein aggregation in TCA cycle, Fe-S cluster protein loss, HSP70 elevation, proteotoxic and oxidative stress ...
Ligang Zhang +5 more
doaj +3 more sources
Frontiers in Immunology, 2022 Rheumatoid arthritis (RA) is an autoimmune disease that severely affects patients’ physical and mental health, leading to chronic synovitis and destruction of bone joints. Although various available clinical treatment options exist, patients respond with varying efficacies due to multiple factors, and there is an urgent need to discover new treatment ...
Jianan Zhao +10 more
openaire +3 more sources
Frontiers in Oncology, 2022 Cuproptosis represents a novel copper-dependent regulated cell death, distinct from other known cell death processes. In this report, a comprehensive analysis of cuproptosis in hepatocellular carcinoma (HCC) was conducted using multi-omics including ...
Xinqiang Li +11 more
doaj +1 more source
A Combined Risk Score Model to Assess Prognostic Value in Patients with Soft Tissue Sarcomas [PDF]
, 2022 A study by Tsvetkov et al. recently published a proposed novel form of copper-induced cell death in Science; however, few studies have looked into the possible mechanism in soft tissue sarcoma (STS).
Duan, Zhengwei +9 more
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Frontiers in Immunology, 2022 BackgroundDue to the different infiltration abundance of immune cells in tumor, the efficacy of immunotherapy varies widely among individuals. Recently, growing evidence suggested that cuproptosis has impact on cancer immunity profoundly.
Zhiyong Cai +7 more
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Molecular subtypes based on cuproptosis-related genes and immune profiles in lung adenocarcinoma
Frontiers in Genetics, 2022 Background: Recent studies have identified several molecular subtypes of lung adenocarcinoma (LUAD) that have different prognoses to help predict the efficacy of immunotherapy. However, the prognostic prediction is less than satisfactory.
Yufei Wang +6 more
doaj +1 more source
Cuproptosis scoring system to predict the clinical outcome and immune response in bladder cancer
Frontiers in Immunology, 2022 Cuproptosis is a novel copper ion-dependent cell death type being regulated in cells, and this is quite different from the common cell death patterns such as apoptosis, pyroptosis, necroptosis, and ferroptosis.
Qiang Song +4 more
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