Results 11 to 20 of about 7,727 (171)

Simultaneous Imaging of Cu⁺ and Cu² ⁺ in Neural Cells Using DNAzyme Probes Reveals Mechanistic Link Between Copper Redox Imbalance and Amyloid Pathology. [PDF]

Angew Chem Int Ed Engl
We develop Cu+‐ and Cu2+‐specific DNAzyme fluorescent probes to visualize both copper redox states in living neurons. Aβ oligomers cause intracellular copper overload, triggering FDX1 dependent cuproptosis and generating ROS. This work links copper redox imbalance with Aβ pathology and offers a selective, sensitive way to monitor copper homeostasis in ...
Shao X, Yang Z, Xu Z, Guo W, Lewis W, Gan B, Lu Y.   +6 more
europepmc   +2 more sources

DACT1 inhibits cuproptosis and promotes cell malignancy via activation of PI3K/AKT signaling in laryngeal squamous cell carcinoma [PDF]

European Journal of Medical Research
Background Laryngeal cancer has one of the highest mortality rates of all head and neck cancers. DACT1 is a cuproptosis-related gene in laryngeal cancer and serves as a risk factor for patient prognosis.
Yan Guo, Jiarui Zhang, Jingchun Ge, Liang Li, Ming Liu, Linli Tian   +5 more
doaj   +2 more sources

The molecular mechanism of cuproptosis and research progress in pancreatic diseases [PDF]

Annals of Medicine
Purpose Cuproptosis has been proven to be a novel mode of cell death, distinct from other types of cell death such as necrosis, ferroptosis, pyroptosis, and apoptosis.
Qizhi Wang, Huijun Chen, Zhen Lv, Peng Zhang, Yingxiao Li, Chuanliang Zhao, Shengqiang Li   +6 more
doaj   +2 more sources

Cuproptosis-related modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of kidney renal clear cell carcinoma

Frontiers in Immunology, 2022
BackgroundDue to the different infiltration abundance of immune cells in tumor, the efficacy of immunotherapy varies widely among individuals. Recently, growing evidence suggested that cuproptosis has impact on cancer immunity profoundly.
Zhiyong Cai, You'e He, Zhengzheng Yu, Jiao Hu, Zicheng Xiao, Xiongbing Zu, Zhenghao Li, Huihuang Li   +7 more
doaj   +1 more source

Molecular subtypes based on cuproptosis-related genes and immune profiles in lung adenocarcinoma

Frontiers in Genetics, 2022
Background: Recent studies have identified several molecular subtypes of lung adenocarcinoma (LUAD) that have different prognoses to help predict the efficacy of immunotherapy. However, the prognostic prediction is less than satisfactory.
Yufei Wang, Chen Zhang, Chengyue Ji, Wenli Jin, Xin He, Shunzhi Yu, Renhua Guo   +6 more
doaj   +1 more source

Cuproptosis scoring system to predict the clinical outcome and immune response in bladder cancer

Frontiers in Immunology, 2022
Cuproptosis is a novel copper ion-dependent cell death type being regulated in cells, and this is quite different from the common cell death patterns such as apoptosis, pyroptosis, necroptosis, and ferroptosis.
Qiang Song, Qiang Song, Rui Zhou, Fangpeng Shu, Wen Fu   +4 more
doaj   +1 more source

Cuproptosis depicts tumor microenvironment phenotypes and predicts precision immunotherapy and prognosis in bladder carcinoma

Frontiers in Immunology, 2022
BackgroundThough immune checkpoint inhibitors (ICIs) exhibit durable efficacy in bladder carcinomas (BLCAs), there are still a large portion of patients insensitive to ICIs treatment.MethodsWe systematically evaluated the cuproptosis patterns in BLCA ...
Huihuang Li, Huihuang Li, Xiongbing Zu, Xiongbing Zu, Jiao Hu, Jiao Hu, Zicheng Xiao, Zicheng Xiao, Zhiyong Cai, Zhiyong Cai, Ning Gao, Ning Gao, Jinbo Chen, Jinbo Chen   +13 more
doaj   +1 more source

Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma

European Journal of Medical Research, 2023
Objective The latest research proposed a novel copper-dependent programmed cell death named cuproptosis. We aimed to elucidate the influence of cuproptosis in clear cell renal cell carcinoma (ccRCC) from a multi-omic perspective.
Maoshu Zhu, Yongsheng Li, Yun Wang, Pingli Lin, Jun Mi, Weimin Zhong   +5 more
doaj   +1 more source

A novel cuproptosis-related molecular pattern and its tumor microenvironment characterization in colorectal cancer

Frontiers in Immunology, 2022
Cuproptosis, or copper-induced cell death, has been reported as a novel noncanonical form of cell death in recent times. However, the potential roles of cuproptosis in the alteration of tumor clinicopathological features and the formation of a tumor ...
Zhonglin Zhu, Zhonglin Zhu, Qiuyan Zhao, Qiuyan Zhao, Wang Song, Wang Song, Junyong Weng, Junyong Weng, Shanbao Li, Tianan Guo, Tianan Guo, Congcong Zhu, Congcong Zhu, Ye Xu, Ye Xu   +14 more
doaj   +1 more source

A comprehensive analysis and validation of cuproptosis-associated genes across cancers: Overall survival, the tumor microenvironment, stemness scores, and drug sensitivity

Frontiers in Genetics, 2022
Background: Cuproptosis is a novel type of cell death induced by copper. Cuproptosis-associated genes play a crucial part in oncogenesis and the growth and metastasis of tumors.
Jinsong Liu, Yueyao Lu, Yuyang Dai, Ying Shen, Cheng Zeng, Xiuling Liu, Huayi Yu, Jianzhong Deng, Wenbin Lu, Wenbin Lu, Wenbin Lu   +10 more
doaj   +1 more source