Results 21 to 30 of about 7,425 (214)

Comprehensive Analysis of Cuproptosis Genes and Identification of Cuproptosis Subtypes in Breast Cancer

Combinatorial Chemistry & High Throughput Screening, 2023
Background: Copper-induced death (cuproptosis) is copper-dependent regulated cell death, which is different from known death mechanisms and is dependent on mitochondrial respiration. However, its effect on breast cancer (BRCA) is unclear. Objective: The objective of this study is to explore the important clinical significance of cuproptosis genes ...
Li, Jialin, Li, Lei, Dong, Yi, Zhong, Bin, Yin, Wei   +4 more
openaire   +2 more sources

Identification of cuproptosis-related subtypes, cuproptosis-related gene prognostic index in hepatocellular carcinoma

Frontiers in Immunology, 2022
Cuproptosis is a novel form of cell death, correlated with the tricarboxylic acid (TCA) cycle. However, the metabolic features and the benefit of immune checkpoint inhibitor (ICI) therapy based on cuproptosis have not yet been elucidated in Hepatocellular carcinoma (HCC).
Lei Ding, Wei Li, Jili Tu, Zhixing Cao, Jizheng Li, Haiming Cao, Junjie Liang, Yiming Liang, Qiangfeng Yu, Gencong Li   +9 more
openaire   +3 more sources

A comprehensive analysis and validation of cuproptosis-associated genes across cancers: Overall survival, the tumor microenvironment, stemness scores, and drug sensitivity

Frontiers in Genetics, 2022
Background: Cuproptosis is a novel type of cell death induced by copper. Cuproptosis-associated genes play a crucial part in oncogenesis and the growth and metastasis of tumors.
Jinsong Liu, Yueyao Lu, Yuyang Dai, Ying Shen, Cheng Zeng, Xiuling Liu, Huayi Yu, Jianzhong Deng, Wenbin Lu, Wenbin Lu, Wenbin Lu   +10 more
doaj   +1 more source

Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma

European Journal of Medical Research, 2023
Objective The latest research proposed a novel copper-dependent programmed cell death named cuproptosis. We aimed to elucidate the influence of cuproptosis in clear cell renal cell carcinoma (ccRCC) from a multi-omic perspective.
Maoshu Zhu, Yongsheng Li, Yun Wang, Pingli Lin, Jun Mi, Weimin Zhong   +5 more
doaj   +1 more source

Cuproptosis depicts tumor microenvironment phenotypes and predicts precision immunotherapy and prognosis in bladder carcinoma

Frontiers in Immunology, 2022
BackgroundThough immune checkpoint inhibitors (ICIs) exhibit durable efficacy in bladder carcinomas (BLCAs), there are still a large portion of patients insensitive to ICIs treatment.MethodsWe systematically evaluated the cuproptosis patterns in BLCA ...
Huihuang Li, Huihuang Li, Xiongbing Zu, Xiongbing Zu, Jiao Hu, Jiao Hu, Zicheng Xiao, Zicheng Xiao, Zhiyong Cai, Zhiyong Cai, Ning Gao, Ning Gao, Jinbo Chen, Jinbo Chen   +13 more
doaj   +1 more source

A novel cuproptosis-related molecular pattern and its tumor microenvironment characterization in colorectal cancer

Frontiers in Immunology, 2022
Cuproptosis, or copper-induced cell death, has been reported as a novel noncanonical form of cell death in recent times. However, the potential roles of cuproptosis in the alteration of tumor clinicopathological features and the formation of a tumor ...
Zhonglin Zhu, Zhonglin Zhu, Qiuyan Zhao, Qiuyan Zhao, Wang Song, Wang Song, Junyong Weng, Junyong Weng, Shanbao Li, Tianan Guo, Tianan Guo, Congcong Zhu, Congcong Zhu, Ye Xu, Ye Xu   +14 more
doaj   +1 more source

Cell death mediated by nanotechnology via the cuproptosis pathway: A novel horizon for cancer therapy

View, 2023
Cuproptosis, the current form of regulated cell death characterized by copper overload, oligomerization of lipoacylated proteins, and loss of Fe–S cluster proteins, has been proposed to function closely with human diseases, including cancer.
Chuang Wei, Qinrui Fu
doaj   +1 more source

Editorial: Molecular and multi-omic approaches in understanding cancer biology and anticancer therapies: current perspectives and new challenges [PDF]

, 2023
Peer ...
A. Abdel-Wahab, Basel, Helmy, Yosra A., M. Saied, Essa   +2 more
core   +1 more source

Cuproptosis-related lncRNAs potentially predict prognosis and therapy sensitivity of breast cancer

Frontiers in Pharmacology, 2023
Background: Cuproptosis-related lncRNAs regulate the biological functions of various cancers. However, the role of cuproptosis-related lncRNAs in breast cancer remains unclear.
Xiwen Wu, Ying Zhang, Gehao Liang, Huizhen Ye   +3 more
doaj   +1 more source

Cuproptosis: mechanisms and links with cancers

Molecular Cancer, 2023
AbstractCuproptosis was a copper-dependent and unique kind of cell death that was separate from existing other forms of cell death. The last decade has witnessed a considerable increase in investigations of programmed cell death, and whether copper induced cell death was an independent form of cell death has long been argued until mechanism of ...
Jiaming Xie, Yannan Yang, Yibo Gao, Jie He   +3 more
openaire   +3 more sources