Results 31 to 40 of about 7,727 (171)

Systematic analysis of the aberrances and functional implications of cuproptosis in cancer

iScience, 2023
Summary: Cuproptosis is a novel form of cell death driven by a copper-dependent proteotoxic stress response whose comprehensive landscape in tumors remains unclear. Here, we comprehensively characterized cuproptosis-related genes (CRGs) across 33 cancers
Jiangbing Li, Boyan Li, Rongrong Zhao, Gang Li   +3 more
doaj   +1 more source

Immune Infiltration in Atherosclerosis is Mediated by Cuproptosis-Associated Ferroptosis Genes [PDF]

, 2023
Aims: In this study, we aimed to identify cuproptosis-associated ferroptosis genes in the atherosclerosis microarray of the Gene Expression Omnibus (GEO) database and to explore hub gene-mediated immune infiltration in atherosclerosis.Background: Immune ...
Ang Gao, Boyu Zhang, Dongze Wang, Hanbing Liu, Qian Xu, Shuhan Li, Tongyu Hou, Yihan Wang, Zhiyuan Gao   +8 more
core   +1 more source

Editorial: Metabolic Regulation Under Oxidative Stress in Cancer [PDF]

, 2023
Oxidative stress has emerged as a key component of cancer metabolism that impacts multiple facets of tumor biology (1). Recent studies have shed light on the complex interplay of cellular redox and its impact on molecular mechanisms that govern metabolic
Bederman, Ilya, Bhattacharya, Pratip K, Dominic, Abishai, Frigo, Daniel E, Subramani, Elavarasan, Vaziri-Gohar, Ali   +5 more
core   +1 more source

Identification of cuproptosis-related molecular subtypes and a novel predictive model of COVID-19 based on machine learning [PDF]

, 2023
BackgroundTo explicate the pathogenic mechanisms of cuproptosis, a newly observed copper induced cell death pattern, in Coronavirus disease 2019 (COVID-19).MethodsCuproptosis-related subtypes were distinguished in COVID-19 patients and associations ...
Dingyu Zhang, Dingyu Zhang, Dingyu Zhang, Hong Luo, Jisong Yan, Xia Zhou   +5 more
core   +1 more source

Impact of Cuproptosis-related markers on clinical status, tumor immune microenvironment and immunotherapy in colorectal cancer: A multi-omic analysis

Computational and Structural Biotechnology Journal, 2023
Background: Cuproptosis, a novel identified cell death form induced by copper, is characterized by aggregation of lipoylated mitochondrial enzymes and the destabilization of Fe–S cluster proteins.
Yanfei Shao, Xiaodong Fan, Xiao Yang, Shuchun Li, Ling Huang, Xueliang Zhou, Sen Zhang, Minhua Zheng, Jing Sun   +8 more
doaj   +1 more source

Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer

Nature Communications, 2023
Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a potential cancer therapeutic. However, the mechanisms underlying the initiation, propagation, and ultimate execution of cuproptosis in tumors remain unknown.
Lianhui Sun, Yuan Zhang, Boyu Yang, Sijun Sun, Pengshan Zhang, Zai Luo, Tingting Feng, Zelin Cui, Ting Zhu, Yuming Li, Zhengjun Qiu, Guangjian Fan, Chen Huang   +12 more
doaj   +1 more source

Significance of cuproptosis- related genes in the diagnosis and classification of psoriasis

Frontiers in Molecular Biosciences, 2023
Cuproptosis is a novel form of cell death linked to mitochondrial metabolism and is mediated by protein lipoylation. The mechanism of cuproptosis in many diseases, such as psoriasis, remains unclear.
Qingyuan Lin, Qingyuan Lin, Jinchao Zhu, Jinchao Zhu, Jun Chen, Shouqiang Jia, Shengdong Nie   +6 more
doaj   +1 more source

A novel cuproptosis pattern and tumor immune microenvironment characterization in urothelial carcinoma of the bladder

Frontiers in Immunology, 2023
BackgroundUrothelial carcinoma of the bladder (UCB) is the most prevalent malignant tumor of the urinary system worldwide, which has a significant recurrence rate despite multiple treatment options available.
Huan Feng, Huan Feng, Huan Feng, Huan Feng, Zhiyao Deng, Zhiyao Deng, Zhiyao Deng, Yibao Huang, Zhuo Liu, Zhuo Liu, Yajun Ruan, Yajun Ruan, Tao Wang, Tao Wang, Tao Wang, Jihong Liu, Jihong Liu   +16 more
doaj   +1 more source

Head and Neck Squamous Cell Carcinoma: Cuproptosis-related Long Non-coding RNAs Predict Prognosis and Immunotherapeutic Response [PDF]

Objective Head and neck squamous cell carcinoma (HNSCC) has a poor prognosis because of high recurrence and metastasis rates and failure of immunotherapy caused by escape of immune cells.
Ding, Yao, Huang, Yi, liang, tao, MO, Xiaoqiang, Wang, Shizi, ZHU, yuanzhi   +5 more
core   +2 more sources

Modulation of Bacterial Iron Homeostasis to Enhance Cuproptosis-like Death for the Treatment of Infected Diabetic Wound [PDF]

Cuproptosis, an emerging cell death pathway, offers an alternative approach for antimicrobial therapy, but it suffers from deficiencies and health risks.
Chang, Yuchen, Dong, Qingrong, Fang, Ge, Gao, Xingfa, Ge, Cuicui, Pu, Kefeng, Shen, Xiaomei, Tao, Yujie, Ye, Rui, Zhou, Ruhong   +9 more
core   +1 more source