Cuproptosis-related genes signature and validation of differential expression and the potential targeting drugs in temporal lobe epilepsy [PDF]
, 2023 Introduction: Temporal lobe epilepsy (TLE) is the most common subtype of epilepsy in adults and is characterized by neuronal loss, gliosis, and sprouting mossy fibers in the hippocampus.
Chunqing Zhang +16 more
core +1 more source
Recent progress of methods for cuproptosis detection
Frontiers in Molecular BiosciencesVarying from other identified cell death pathways, cuproptosis is a new type of regulated cell death characterized by excess Cu ions, abnormal aggregation of lipoylated proteins in TCA cycle, loss of Fe-S cluster proteins, upregulation of HSP70, leading ...
Ligang Zhang +11 more
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundCuproptosis, the most recently identified and regulated cell death, depends on copper ions in vivo. Copper regulates the pathogenesis of Idiopathic pulmonary fibrosis (IPF), but the mechanism of action underlying cuproptosis in IPF remains ...
Chuanqing Jing +6 more
doaj +1 more source
Tumor glucose reprogramming suppresses cuproptosis: A review [PDF]
Cuproptosis is a copper-dependent form of regulated cell death that begins when ferredoxin 1 (FDX1) reduces Cu²⁺ to Cu¹⁺, allowing the ion to bind lipoylated enzymes of the tricarboxylic-acid (TCA) cycle, drive protein aggregation, dismantle iron–sulphur
Chen, Jing-Song +2 more
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A novel cuproptosis-related lncRNAs signature predicts prognostic and immune of bladder urothelial carcinoma [PDF]
, 2023 Bladder Urothelial Carcinoma (BLCA) remains the most common urinary system tumor, and its prognosis is poor. Cuproptosis is a recently discovered novel cell death involved in the development of tumor cells.
Jing Dai +3 more
core +1 more source
Screening and validating genes associated with cuproptosis in systemic lupus erythematosus by expression profiling combined with machine learning [PDF]
Cell death has long been a focal point in life sciences research, and recently, scientists have discovered a novel form of cell death induced by copper, termed cuproptosis.
Cheng, Ruoying +4 more
core +2 more sources
Editorial: Prognostic factors in non-small cell lung cancer [PDF]
, 2023 status ...
Baudo, Massimo +3 more
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A novel cuproptosis-related prognostic signature and potential value in HCC immunotherapy
Frontiers in Molecular Biosciences, 2022 Background: Copper metabolism plays an important role in the tumor microenvironment, and cuproptosis is the last discovered programmed cell death process.
Xiang-Xu Wang +8 more
doaj +1 more source
Mitochondria-Targeted Multifunctional Nanoparticles Combine Cuproptosis and Programmed Cell Death-1 Downregulation for Cancer Immunotherapy [PDF]
The combination of cuproptosis and immune checkpoint inhibition has shown promise in treating malignant tumors. However, it remains a challenge to deliver copper ions and immune checkpoint inhibitors efficiently and simultaneously to tumors.
Li, Youyou +3 more
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A cuproptosis random forest cox score model-based evaluation of prognosis, mutation characterization, immune infiltration, and drug sensitivity in hepatocellular carcinoma [PDF]
, 2023 BackgroundHepatocellular carcinoma is the third most deadly malignant tumor in the world with a poor prognosis. Although immunotherapy represents a promising therapeutic approach for HCC, the overall response rate of HCC patients to immunotherapy is less
Fengyue Zhang +4 more
core +1 more source