Cuproptosis-related gene FDX1 as a prognostic biomarker for kidney renal clear cell carcinoma correlates with immune checkpoints and immune cell infiltration [PDF]
, 2023 Background: Kidney renal clear cell carcinoma (KIRC) is not sensitive to radiotherapy and chemotherapy, and only some KIRC patients can benefit from immunotherapy and targeted therapy.
Haixin Chen +3 more
core +1 more source
Identification of cuproptosis-related molecular subtypes and a novel predictive model of COVID-19 based on machine learning [PDF]
, 2023 BackgroundTo explicate the pathogenic mechanisms of cuproptosis, a newly observed copper induced cell death pattern, in Coronavirus disease 2019 (COVID-19).MethodsCuproptosis-related subtypes were distinguished in COVID-19 patients and associations ...
Dingyu Zhang +5 more
core +1 more source
Systematic analysis of the aberrances and functional implications of cuproptosis in cancer
iScience, 2023 Summary: Cuproptosis is a novel form of cell death driven by a copper-dependent proteotoxic stress response whose comprehensive landscape in tumors remains unclear. Here, we comprehensively characterized cuproptosis-related genes (CRGs) across 33 cancers
Jiangbing Li +3 more
doaj +1 more source
Significance of cuproptosis- related genes in the diagnosis and classification of psoriasis
Frontiers in Molecular Biosciences, 2023 Cuproptosis is a novel form of cell death linked to mitochondrial metabolism and is mediated by protein lipoylation. The mechanism of cuproptosis in many diseases, such as psoriasis, remains unclear.
Qingyuan Lin +6 more
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundUrothelial carcinoma of the bladder (UCB) is the most prevalent malignant tumor of the urinary system worldwide, which has a significant recurrence rate despite multiple treatment options available.
Huan Feng +16 more
doaj +1 more source
Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer
Nature Communications, 2023 Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a potential cancer therapeutic. However, the mechanisms underlying the initiation, propagation, and ultimate execution of cuproptosis in tumors remain unknown.
Lianhui Sun +12 more
doaj +1 more source
Immune Infiltration in Atherosclerosis is Mediated by Cuproptosis-Associated Ferroptosis Genes [PDF]
, 2023 Aims: In this study, we aimed to identify cuproptosis-associated ferroptosis genes in the atherosclerosis microarray of the Gene Expression Omnibus (GEO) database and to explore hub gene-mediated immune infiltration in atherosclerosis.Background: Immune ...
Ang Gao +8 more
core +1 more source
Modulation of Bacterial Iron Homeostasis to Enhance Cuproptosis-like Death for the Treatment of Infected Diabetic Wound [PDF]
Cuproptosis, an emerging cell death pathway, offers an alternative approach for antimicrobial therapy, but it suffers from deficiencies and health risks.
Chang, Yuchen +9 more
core +1 more source
Head and Neck Squamous Cell Carcinoma: Cuproptosis-related Long Non-coding RNAs Predict Prognosis and Immunotherapeutic Response [PDF]
Objective Head and neck squamous cell carcinoma (HNSCC) has a poor prognosis because of high recurrence and metastasis rates and failure of immunotherapy caused by escape of immune cells.
Ding, Yao +5 more
core +2 more sources
Tumor glucose reprogramming suppresses cuproptosis: A review [PDF]
Cuproptosis is a copper-dependent form of regulated cell death that begins when ferredoxin 1 (FDX1) reduces Cu²⁺ to Cu¹⁺, allowing the ion to bind lipoylated enzymes of the tricarboxylic-acid (TCA) cycle, drive protein aggregation, dismantle iron–sulphur
Chen, Jing-Song +2 more
core +2 more sources