Results 71 to 80 of about 7,425 (214)

Volumetric Engineered 3D Drug Reservoir Against Diabetic Implant Infection via Cuproptosis-Like Bacterial Death and Hunger-Triggered Maintenance of Mitochondrial Integrity [PDF]

Implant-associated infections in diabetic patients pose critical challenges due to immune-metabolic dysregulation that exacerbates biofilm persistence and tissue damage.
Chen, Tao, Jian, Guangyu, Jiang, Min, Li, Dize, Qin, Hongrui, Tang, Ping, van der Mei, Henny C., Wei, Hongjiang, Zhao, Hongyong   +8 more
core   +1 more source

Editorial: Prognostic factors in non-small cell lung cancer [PDF]

, 2023
status ...
Baudo, Massimo, Mutti, Luciano, Rahouma, Mohamed, Zhang, Jun   +3 more
core   +2 more sources

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, EarlyView.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

Construction and comprehensive analysis of a curoptosis-related lncRNA signature for predicting prognosis and immune response in cervical cancer [PDF]

, 2023
Cuproptosis (copper-ion-dependent cell death) is an unprogrammed cell death, and intracellular copper accumulation, causing copper homeostasis imbalance and then leading to increased intracellular toxicity, which can affect the rate of cancer cell growth
Hongmei Xia, Jianfeng Zheng, Li Liu, Liyan Ji, Qiaoling Wu, Xintong Cai, Yang Sun   +6 more
core   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

A novel approach to enhance glioblastoma multiforme treatment efficacy:non-coding RNA targeted therapy and adjuvant approaches [PDF]

BACKGROUND: Glioblastoma multiforme (GBM) is a lethal brain tumor. With the current gold standard chemotherapy treatment, temozolomide (TMZ), many patients do not survive beyond one year.
Chen, Xiaoli, Cheng, Lixin, Cheung, Kenneth Chat Pan, Dai, Hong, Huang, Wenqiong, Liu, Meijun, Mauro, Claudio, Wang, Yuying, Yang, Jiawen, Zeng, Yu   +9 more
core   +1 more source

Copper depletion-induced tumor cuproptosis

Chemical Science
Copper accumulated-cuproptosis has been extensively investigated, copper depleted-cuproptosis remains largely unexplored. Based on the solubility product principle, a novel copper depletion-induced tumor cuproptosis strategy was developed.
Min Zhou, Faheem Muhammad, Yihong Zhang, Tong Li, Jiayuan Feng, Jingyuan Zhao, Hui Wei   +6 more
openaire   +2 more sources

Multifunctional H2S‐activated metal‐organic framework systems for targeted colorectal cancer imaging and synergistic copper‐induced tumor regression

BMEMat, EarlyView.
The in situ reaction of Cu‐MOFs with endogenous H2S enabled PA imaging and facilitated combined PTT/chemotherapy for colorectal cancer therapy. Abstract Stimuli‐responsive nanomaterials offer significant potential for enhancing diagnostic accuracy, optimizing therapeutic efficacy, and advancing precision theranostics.
Nannan Zheng, Qinghui Wang, Zhiyue Cao, Chao Yu, Renkai Zhang, Kaiyan Xiang, Haoguang Wu, Kai Li, Qianqian Ni, Qiuyue Ma, Jing Mu, Xiaoyuan Chen, Liangcan He, Shaoqin Liu   +13 more
wiley   +1 more source

The core genes of cuproptosis assists in discerning prognostic and immunological traits of clear cell renal cell carcinoma

Frontiers in Oncology, 2022
ObjectiveCuproptosis, a nascent and unique pattern of cell death, is poised to spark a new rush of biological research. Yet, the subsumed mechanism of cuproptosis in carcinoma is not wholly clarified.
Binxiang Chu, Zhenghua Hong, Xiaohe Zheng   +2 more
doaj   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source