Results 31 to 40 of about 763,623 (189)

Plasma Mitochondrial DNA and Necroptosis as Prognostic Indicators in Critically Ill Patients with Sepsis

Biomedicines, 2022
Mitochondrial DNA (mtDNA) has been identified as a biomarker for predicting sepsis mortality. Although preclinical studies suggested that necroptosis could explain the mechanistic link of mtDNA in sepsis, this is not yet evident in patients with sepsis ...
Hayoung Choi, Hongseok Yoo, Jin Young Lee, Junseon Park, Kyeongman Jeon   +4 more
doaj   +1 more source

DAMPs and alarmin gene expression patterns in aging healthy and diseased mucosal tissues

Frontiers in Oral Health, 2023
IntroductionPeriodontitis is delineated by a dysbiotic microbiome at sites of lesions accompanied by a dysregulated persistent inflammatory response that undermines the integrity of the periodontium.
O. A. Gonzalez, S. S. Kirakodu, J. L. Ebersole   +2 more
doaj   +1 more source

Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle [PDF]

, 2014
Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and ...
Abe, Alexeyev, Andersson, Andersson, Ba, Babior, Bartoloni, Berger, Blyth, Brill, Brinkmann, Cadet, Collins, Cooke, Csanád Z. Bachrati, David, Ding, Dostert, Ermakov, Ermakov, Ferguson, Fuchs, Gahan, Gedik, Gehrke, Hajizadeh, Halle, Hiramoto, Huang, Huang, Huang, Huttunen, Ishikawa, Ivana, Ivanov, Jahr, Jia, Kang, Kanneganti, Kazak, Klebanoff, Knaapen, Kondo, Kostyuk, Kostyuk, Krieg, Kuechle, Lane, Lange, Latz, Li, Malins, Mariathasan, Munoz-Gamez, Nakahira, Oka, Pacher, Parvatiyar, Pasheva, Pinti, Polk, Rathinam, Saitoh, Saxena, Scaffidi, Schroder, Shimada, Shokolenko, Sun, Suter, Suzuki, Swindall, Tadie, Taguchi, Takeda, Takeda, Tang, Tang, Thomson, Timea Pálmai-Pallag, Unterholzner, Urbonaviciute, Venereau, Volcic, Weinberg, Weiss, Wilson, Wu, Yan, Yang, Yoshida, Yoshihara, Yotsumoto, You, Yousefi, Zhang, Zhang, Zhang, Zhang, Zhang, Zhou   +100 more
core   +1 more source

Mitochondrial damage-associated molecular patterns and vascular function [PDF]

European Heart Journal, 2014
Immune system activation occurs not only due to foreign stimuli, but also due to endogenous molecules. As such, endogenous molecules that are released into the circulation due to cell death and/or injury alarm the immune system that something has disturbed homeostasis and a response is needed.
Camilla Ferreira, Wenceslau, Cameron G, McCarthy, Theodora, Szasz, Kathryn, Spitler, Styliani, Goulopoulou, R Clinton, Webb   +5 more
openaire   +2 more sources

GRP-3 and KAPP, encoding interactors of WAK1, negatively affect defense responses induced by oligogalacturonides and local response to wounding [PDF]

, 2016
Conserved microbe-associated molecular patterns (MAMPs) and damage-associated molecular patterns (DAMPs) act as danger signals to activate the plant immune response.
CERVONE, Felice, DE LORENZO, Giulia, GRAMEGNA, GIOVANNA, MODESTI, VANESSA, SAVATIN, DANIEL VALENTIN, SICILIA, Francesca   +5 more
core   +1 more source

Damage-Associated Molecular Pattern-Triggered Immunity in Plants [PDF]

Frontiers in Plant Science, 2019
كعملية عالمية في الكائنات متعددة الخلايا، بما في ذلك الحيوانات والنباتات، عادة ما تصدر الخلايا إشارات خطر عند المعاناة من هجمات الميكروبات والحيوانات العاشبة، أو الأضرار المادية. تشمل هذه الإشارات، التي يطلق عليها الأنماط الجزيئية المرتبطة بالضرر (DAMPs)، بشكل أساسي جدار الخلية أو شظايا البروتين خارج الخلية والببتيدات والنيوكليوتيدات والأحماض الأمينية.
Sen Hou, Zunyong Liu, Hexi Shen, Daoji Wu   +3 more
openaire   +3 more sources

Key Events Participating in the Pathogenesis of  Alcoholic Liver Disease

Biomolecules, 2017
Alcoholic liver disease (ALD) is a leading cause of morbidity and mortality worldwide. It ranges from fatty liver to steatohepatitis, fibrosis, cirrhosis and hepatocellular carcinoma.The most prevalent forms of ALD are alcoholic fatty liver, alcoholic ...
Fernando Magdaleno, Chuck C. Blajszczak, Natalia Nieto   +2 more
doaj   +1 more source

Activation and regulation mechanisms of NOD-like receptors based on structural biology

Frontiers in Immunology, 2022
Innate immunity is a primary defense system against microbial infections. Innate immune pattern recognition receptors (PRRs) play pivotal roles in detection of invading pathogens.
Umeharu Ohto
doaj   +1 more source

Various forms of tissue damage and danger signals following hematopoietic stem-cell transplantation [PDF]

, 2015
Hematopoietic stem-cell transplantation (HSCT) is the most potent curative therapy for many malignant and non-malignant disorders. Unfortunately, a major complication of HSCT is graft-versus-host disease (GVHD), which is mediated by tissue damage ...
Paczesny, Sophie, Ramadan, Abdularouf
core   +2 more sources

Bullatacin triggers immunogenic cell death of colon cancer cells by activating endoplasmic reticulum chaperones

Journal of Inflammation, 2021
Background It is well accepted that the immune system efficiently contributes to positive outcomes of chemotherapeutic cancer treatment by activating immunogenic cell death (ICD).
Fangtian Fan, Peiliang Shen, Yue Ma, Wangbo Ma, Hongyan Wu, Hao Liu, Qing An   +6 more
doaj   +1 more source