Results 71 to 80 of about 763,623 (189)

TLR activation regulates damage‐associated molecular pattern isoforms released during pyroptosis [PDF]

The EMBO Journal, 2012
Infection of macrophages by bacterial pathogens can trigger Toll-like receptor (TLR) activation as well as Nod-like receptors (NLRs) leading to inflammasome formation and cell death dependent on caspase-1 (pyroptosis). Complicating the study of inflammasome activation is priming.
Sanna, Nyström, Daniel J, Antoine, Peter, Lundbäck, John G, Lock, Andreia F, Nita, Kari, Högstrand, Alf, Grandien, Helena, Erlandsson-Harris, Ulf, Andersson, Steven E, Applequist   +9 more
openaire   +3 more sources

The Etiopathogenesis of Kawasaki Disease: Evolving Understanding of Diverse Triggers

Immunity, Inflammation and Disease
Background Kawasaki disease (KD) is a leading cause of acquired heart disease in children. Evidence suggests that microbial and nonmicrobial triggers for KD differ across geographical regions and environmental conditions.
Toshiro Hara, Yasunari Sakai
doaj   +1 more source

Interpreting the dependence of mutation rates on age and time [PDF]

, 2015
Mutations can arise from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that are not repaired correctly. We introduce a model that relates the source of mutations to their accumulation with cell divisions, providing
Gao, Ziyue, Przeworski, Molly, Sella, Guy, Wyman, Minyoung J.   +3 more
core   +5 more sources

Mitochondrial damage-associated molecular patterns activate γδ T-cells

Innate Immunity, 2013
Gamma delta T-cells have been shown to be important in the early immunoinflammatory response to injury, which can be independent of infection. This sterile inflammatory response is believed to be, in part, associated with danger-associated molecular patterns (DAMPs).
Martin G, Schwacha, Meenakshi, Rani, Qiong, Zhang, Oliver, Nunez-Cantu, Andre P, Cap   +4 more
openaire   +2 more sources

Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response. [PDF]

, 2013
BackgroundTraumatic brain injury (TBI) results in irreversible damage at the site of impact and initiates cellular and molecular processes that lead to secondary neural injury in the surrounding tissue.
Ford, Byron D, Ford, Gregory D, Gates, Alicia S, Laplaca, Michelle C, Surles-Zeigler, Monique C, White, Todd E   +5 more
core   +2 more sources

Comprehending toll-like receptors: pivotal element in the pathogenesis of sepsis and its complications

Frontiers in Immunology
Sepsis, a critical systemic inflammatory response syndrome elicited by pathogenic microorganisms, poses a significant challenge in clinical practice due to its rapid progression and potential for multi-organ failure.
Wei Wang, Shengtian Mu, Dongli Yan, Huan Qin, Zhen Zheng   +4 more
doaj   +1 more source

DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination

Frontiers in Immunology, 2018
Recently, it was reported that 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD), a common pharmaceutical additive, can act as a vaccine adjuvant to enhance protective type-2 immunogenicity to co-administered seasonal influenza split vaccine by inducing host ...
Tomoya Hayashi, Tomoya Hayashi, Masatoshi Momota, Masatoshi Momota, Etsushi Kuroda, Etsushi Kuroda, Takato Kusakabe, Takato Kusakabe, Shingo Kobari, Kotaro Makisaka, Yoshitaka Ohno, Yoshitaka Ohno, Yusuke Suzuki, Fumika Nakagawa, Michelle S. J. Lee, Cevayir Coban, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Ken J. Ishii, Ken J. Ishii, Hidetoshi Arima, Hidetoshi Arima   +22 more
doaj   +1 more source

Separase prevents genomic instability by controlling replication fork speed [PDF]

, 2016
Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development.
Cucco, Francesco, Palumbo, Elisa, Camerini, Serena, D'Alessio, Barbara, Quarantotti, Valentina, Casella, Maria Luisa, Rizzo, Ilaria Maria, Cukrov, Dubravka, Delia, Domenico, Russo, Antonella, Crescenzi, Marco, Musio, Antonio   +11 more
core   +4 more sources

Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases

Rheumatology & Autoimmunity, 2022
All organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli. The immune system activates when damaged or injured cells release damage‐associated molecular patterns (DAMPs).
Na Kang, Xiaohang Liu, Kabeer Haneef, Wanli Liu   +3 more
doaj   +1 more source

Aging cellular networks: chaperones as major participants

, 2006
We increasingly rely on the network approach to understand the complexity of cellular functions. Chaperones (heat shock proteins) are key "networkers", which have among their functions to sequester and repair damaged protein. In order to link the network
Agoston, Barabasi, Blais, Borodina, C. Sőti, Chan, Cherian, Cowen, Csermely, Csermely, Csermely, Csermely, Donaldson, Dorogovtsev, Dukan, Fares, Ferrarini, Gavin, Goldberger, Hayflick, He, Herndon, Heydari, Himmelstein, Imai, Irish, Macario, Morimoto, Mukai, Nardai, Nardai, Nollen, P. Csermely, Paulsson, Promislow, Pál, Queitsch, Rual, Rutherford, Schwarzer, Song, Stadtman, Stelzl, Sőti, Sőti, Sőti, Sőti, von Mering, Werner-Washburne, Westerheide, White, Yam, Young, Young, Zhao, Zhu, Zou   +56 more
core   +1 more source