Results 151 to 160 of about 59,000 (187)
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Journal of Clinical Oncology, 2022
e14524 Background: Immunogenic cell death (ICD) is known for the release of DAMPS from tumor cells. We aimed to find signals of ICD by assessing the variation of plasma DAMPS (HMGB1 and S100A8) after vs. before standard of care (SoC) systemic treatment in patients with advanced solid tumors. Methods: Patients scheduled to start a new line of systemic
Vicente Valenti +10 more
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e14524 Background: Immunogenic cell death (ICD) is known for the release of DAMPS from tumor cells. We aimed to find signals of ICD by assessing the variation of plasma DAMPS (HMGB1 and S100A8) after vs. before standard of care (SoC) systemic treatment in patients with advanced solid tumors. Methods: Patients scheduled to start a new line of systemic
Vicente Valenti +10 more
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Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox
Trends in Immunology, 2007Immune responses are initiated and perpetuated by molecules derived from microorganisms pathogen-associated molecular-pattern molecules or from the damage or death of host cells [damage-associated molecular-pattern (DAMP) molecules]. Many DAMPs are nuclear or cytosolic proteins with defined intracellular function that, when released outside the cell ...
Anna, Rubartelli, Michael T, Lotze
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Targeting Damage-Associated Molecular Pattern Molecules (DAMPs) and DAMP Receptors in Melanoma
2013Damage-associated molecular pattern molecules (DAMPs) are proteins released from cells under stress due to nutrient deprivation, hypoxia, trauma, or treatment with chemotherapy, among a variety of other causes. When released, DAMPs activate innate immunity, providing a pathway to a systemic inflammatory response in the absence of infection.
Brian A, Boone, Michael T, Lotze
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Eosinophilic Granulocytes and Damage-associated Molecular Pattern Molecules (DAMPs)
Journal of Immunotherapy, 2007The development of a tumor over many years typically leads to reciprocal alternations in the host and the tumor, enabling tumor growth paradoxically in the setting of substantial necrosis and inflammation. When evaluating a tumor, it is important to assess 3 elements: (1) the quantity and quality of tumor-associated leukocytes, (2) their state of ...
Ramin, Lotfi +2 more
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Annual Review of Phytopathology, 2021
Danger signals trigger immune responses upon perception by a complex surveillance system. Such signals can originate from the infectious nonself or the damaged self, the latter termed damage-associated molecular patterns (DAMPs). Here, we apply Matzinger's danger model to plant innate immunity to discuss the adaptive advantages of DAMPs and their ...
Kiwamu, Tanaka, Martin, Heil
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Danger signals trigger immune responses upon perception by a complex surveillance system. Such signals can originate from the infectious nonself or the damaged self, the latter termed damage-associated molecular patterns (DAMPs). Here, we apply Matzinger's danger model to plant innate immunity to discuss the adaptive advantages of DAMPs and their ...
Kiwamu, Tanaka, Martin, Heil
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Toll-Like Receptor 4 Activation by Damage-Associated Molecular Patterns (DAMPs)
2020Mammalian toll-like receptors (TLRs) act as key sensors of pathogen-associated molecular patterns (PAMP), such as bacterial lipopolysaccharides (LPS), lipopeptides, and flagellin, which are molecular structures present in microbial cells but not in host cells.
Monica Molteni, Carlo Rossetti
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Natural antibodies as a sensor of electronegative damage-associated molecular patterns (DAMPs)
Free Radical Biology and Medicine, 2014Natural antibodies (Abs), predominantly IgMs, play an important function in the host response to the recognition of endogenous danger signals called damage-associated molecular patterns (DAMPs). Many of the natural IgM Abs also show several different antigenic cross-reactivities toward covalently modified proteins, such as oxidized low-density ...
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[DAMPs (damage-associated molecular patterns) and inflammation].
Nihon rinsho. Japanese journal of clinical medicine, 2016Post-ischemic inflammation is re-appraised as an important player in the progression of ischemic stroke. Activation of inflammatory cells via Toll-like receptor 2 (TLR2) and TLR4 is caused by several damage-associated molecular patterns (DAMPs), including high mobility group box-1 (HMGB-1) and heat shock proteins.
Hiroaki, Ooboshi, Takashi, Shichita
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Damage-associated molecular patterns (DAMPs) as future plant vaccines that protect crops from pests
Scientia Horticulturae, 2018Abstract Domestication reduced the resistance of most crops which, therefore, require an ever-increasing application of pesticides. Nevertheless, in most domesticated species, the resistance against herbivores and disease agents can be activated by so-called elicitors.
Elizabeth Quintana-Rodriguez +3 more
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2015
Damage-associated molecular pattern molecules (DAMPs) are endogenous molecules that are constitutively expressed and released upon tissue damage, resulting in activation of the immune system. In the absence of injury or infection, DAMPs play important intracellular roles.
Jungo, Kato, Camilla I, Svensson
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Damage-associated molecular pattern molecules (DAMPs) are endogenous molecules that are constitutively expressed and released upon tissue damage, resulting in activation of the immune system. In the absence of injury or infection, DAMPs play important intracellular roles.
Jungo, Kato, Camilla I, Svensson
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