Results 1 to 10 of about 89,563 (272)

From stress signals to fertility challenges: the role of damage-associated molecular patterns in male reproduction [PDF]

Frontiers in Immunology
Male infertility is influenced by genetic abnormalities, hormonal imbalances, lifestyle factors, and environmental exposures. Recently, Damage-Associated Molecular Patterns (DAMPs) have emerged as key players in male reproductive health, particularly in ...
Heran Cao, Heran Cao, Shujuan Liu, Shichao Cui, Shichao Cui, Hua Nie, Hua Nie, Xiaohua Liu, Xiaohua Liu, Weibing Qin, Weibing Qin   +10 more
doaj   +2 more sources

Silibinin induces immunogenic cell death in cancer cells and enhances the induced immunogenicity by chemotherapy [PDF]

BioImpacts, 2023
Introduction: Silibinin is a natural flavonoid compound known to induce apoptosis in cancer cells. Despite silibinin's safety and efficacy as an anticancer drug, its effects on inducing immunogenic cell death (ICD) are largely unknown.
Sevda Jafari, Saba Heydarian, Raymond Lai, Elnaz Mehdizadeh Aghdam, Ommoleila Molavi   +4 more
doaj   +1 more source

Using PAMPs and DAMPs as adjuvants in cancer vaccines

Human Vaccines & Immunotherapeutics, 2021
Immunotherapy for cancer has attracted considerable attention. As one of the immunotherapeutics, tumor vaccines exert great potential for cancer immunotherapy.
Huanyou Sun, Wenwen Hu, Yinan Yan, Zichun Zhang, Yuxin Chen, Xuefan Yao, Ling Teng, Xinyuan Wang, Dafei Chai, Junnian Zheng, Gang Wang   +10 more
doaj   +1 more source

Can High Mobility Group Box 1 Protein Predict Ongoing Subclinical Inflammation in Patients With Familial Mediterranean Fever?

Journal of Behçet Uz Children's Hospital, 2023
Objective: Familial Mediterranean fever (FMF) is an autoinflammatory disease that commonly presents with fever, peritonitis, and pleuritis. Recent studies have reported ongoing inflammation in the attack-free period of patients with FMF.
Betül Öztürk, Esra Baskın, Kaan Gülleroğlu, Begüm Avcı, Nilüfer Bayraktar, Feride İffet Şahin   +5 more
doaj   +1 more source

DAMP-mediated inflammation and regulated cell death in immunoinflammatory rheumatic diseases

Медицинская иммунология, 2023
The state of autoreactivity of innate immunity dominates in the pathogenesis of immunoinflammatory rheumatic diseases,  inducing non-infectious “sterile” inflammation.
M. Z. Saidov
doaj   +1 more source

DAMPs, ageing, and cancer: The ‘DAMP Hypothesis’ [PDF]

Ageing Research Reviews, 2015
Ageing is a complex and multifactorial process characterized by the accumulation of many forms of damage at the molecular, cellular, and tissue level with advancing age. Ageing increases the risk of the onset of chronic inflammation-associated diseases such as cancer, diabetes, stroke, and neurodegenerative disease.
Jin, Huang, Yangchun, Xie, Xiaofang, Sun, Herbert J, Zeh, Rui, Kang, Michael T, Lotze, Daolin, Tang   +6 more
openaire   +2 more sources

Immunogenic Cell Death-Relevant Damage-Associated Molecular Patterns and Sensing Receptors in Triple-Negative Breast Cancer Molecular Subtypes and Implications for Immunotherapy

Frontiers in Oncology, 2022
ObjectivesTriple-negative breast cancer (TNBC) is defined as a highly aggressive type of breast cancer which lacks specific biomarkers and drug targets.
Ming Xu, Ming Xu, Jin-hua Lu, Ya-zhen Zhong, Jing Jiang, Yue-zhong Shen, Jing-yang Su, Sheng-you Lin   +7 more
doaj   +1 more source

AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke

Cell Reports, 2021
Summary: The sterile inflammation caused by damage-associated molecular patterns (DAMPs) worsens the prognosis following primary injury such as ischemic stroke. However, there are no effective treatments to regulate DAMPs.
Natsumi Maehara, Kaori Taniguchi, Ami Okuno, Hideaki Ando, Aika Hirota, Zhiheng Li, Ching-Ting Wang, Satoko Arai, Toru Miyazaki   +8 more
doaj   +1 more source

Tumor-related HSP70 released after cryo-thermal therapy targeted innate immune initiation in the antitumor immune response

International Journal of Hyperthermia, 2020
Purpose In our previous study, a novel cryo-thermal therapy that could stimulate the maturation of innate immune cells to subsequently activate the CD4+Th1 cell-dominated antitumor response was developed.
Jun Zhu, Yue Lou, Ping Liu, Lisa X. Xu
doaj   +1 more source

Damage-associated molecular patterns and sensing receptors based molecular subtypes in malignant pleural mesothelioma and implications for immunotherapy

Frontiers in Immunology, 2023
ObjectivesMalignant pleural mesothelioma (MPM) is characterized as an incredibly aggressive form of cancer with a dismal diagnosis and a dearth of specific biomarkers and therapeutic options.
Zheng Liu, Rui Wan, Hua Bai, Jie Wang
doaj   +1 more source