Results 21 to 30 of about 89,563 (272)

Role of Damage-Associated Molecular Patterns in Septic Acute Kidney Injury, From Injury to Recovery

Frontiers in Immunology, 2021
Damage-associated molecular patterns (DAMPs) are a group of immunostimulatory molecules, which take part in inflammatory response after tissue injury. Kidney-specific DAMPs include Tamm-Horsfall glycoprotein, crystals, and uromodulin, released by tubular
Pierre-Olivier Ludes, Pierre-Olivier Ludes, Charles de Roquetaillade, Charles de Roquetaillade, Benjamin Glenn Chousterman, Benjamin Glenn Chousterman, Julien Pottecher, Julien Pottecher, Alexandre Mebazaa, Alexandre Mebazaa   +9 more
doaj   +1 more source

Linking Cellular and Mechanical Processes in Articular Cartilage Lesion Formation: A Mathematical Model [PDF]

, 2016
A severe application of stress on articular cartilage can initiate a cascade of biochemical reactions that can lead to the development of osteoarthritis.
Ayati, Bruce P., Brouillette, Marc J., Kapitanov, Georgi I., Martin, James A., Wang, Xiayi   +4 more
core   +3 more sources

Trial watch: dendritic cell vaccination for cancer immunotherapy

OncoImmunology, 2019
Dendritic- cells (DCs) have received considerable attention as potential targets for the development of anticancer vaccines. DC-based anticancer vaccination relies on patient-derived DCs pulsed with a source of tumor-associated antigens (TAAs) in the ...
Jenny Sprooten, Jolien Ceusters, An Coosemans, Patrizia Agostinis, Steven De Vleeschouwer, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi, Abhishek D. Garg   +8 more
doaj   +1 more source

A damage-associated molecular patterns-related gene signature for the prediction of prognosis and immune microenvironment in children stage III acute lymphoblastic leukemia

Frontiers in Pediatrics, 2022
BackgroundImmunogenic cell death (ICD)-mediated immune response provides a strong rationale to overcome immune evasion in acute lymphoblastic leukemia (ALL). ICD will produce damage-associated molecular patterns (DAMPs) in tumor microenvironment. However,
Feng Zhao, Feng Zhao, Qiuyu Lin, Xiayu Xiang, Wei Xiang, Wei Xiang   +5 more
doaj   +1 more source

Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells

OncoImmunology, 2019
The major goal of radiotherapy is the induction of tumor cell death. Additionally, radiotherapy can function as in situ cancer vaccination by exposing tumor antigens and providing adjuvants for anti-tumor immune priming. In this regard, the mode of tumor
Julia Krombach, Roman Hennel, Nikko Brix, Michael Orth, Ulrike Schoetz, Anne Ernst, Jessica Schuster, Gabriele Zuchtriegel, Christoph A. Reichel, Susanne Bierschenk, Markus Sperandio, Thomas Vogl, Steffen Unkel, Claus Belka, Kirsten Lauber   +14 more
doaj   +1 more source

Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]

, 2019
Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix, Krech, Jana, Rolfs, Nele, Schmitt, Katharina R. L., Tong, Giang, Wowro, Sylvia J.   +5 more
core   +1 more source

Essential Role of Host Double-Stranded DNA Released from Dying Cells by Cationic Liposomes for Mucosal Adjuvanticity

Vaccines, 2019
Infectious disease remains a substantial cause of death. To overcome this issue, mucosal vaccine systems are considered to be a promising strategy. Yet, none are approved for clinical use, except for live-attenuated mucosal vaccines, mainly owing to the ...
Rui Tada, Akihiro Ohshima, Yuya Tanazawa, Akari Ohmi, Saeko Takahashi, Hiroshi Kiyono, Jun Kunisawa, Yukihiko Aramaki, Yoichi Negishi   +8 more
doaj   +1 more source

Plant–Plant Communication: Is There a Role for Volatile Damage-Associated Molecular Patterns?

Frontiers in Plant Science, 2020
Damage-associated molecular patterns (DAMPs) are an ancient form of tissue-derived danger or alarm signals that initiate cellular signaling cascades, which often initiate defined defense responses.
Anja K. Meents, Axel Mithöfer
doaj   +1 more source

Differential Expression of Circulating Damage-Associated Molecular Patterns in Patients with Coronary Artery Ectasia

Biomolecules, 2023
Coronary artery ectasia (CAE) is defined as abnormal dilation of a coronary artery with a diameter exceeding that of adjacent normal arterial segment by >1.5 times.
James N. Tsoporis, Andreas S. Triantafyllis, Andreas S. Kalogeropoulos, Shehla Izhar, Angelos G. Rigopoulos, Loukianos S. Rallidis, Eleftherios Sakadakis, Ioannis K. Toumpoulis, Vasileios Salpeas, Howard Leong-Poi, Thomas G. Parker, Ioannis Rizos   +11 more
doaj   +1 more source

Damping Mechanisms

, 2014
Chapter 6 The term damping is used to describe the means by which oscillation amplitudes are reduced through irreversible removal of vibratory energy in a mechanical system or a component. Dissipation, on the other hand, refers to the mechanism by which irreversible energy transfer, from vibratory to thermal, takes place.
Akay, Adnan, CARCATERRA, Antonio
openaire   +2 more sources