mRNA decay pre-complex assembly drives timely cell-state transitions during differentiation [PDF]
Cell ReportsSummary: Complexes that control mRNA stability and translation promote timely cell-state transitions during differentiation by ensuring appropriate expression patterns of key developmental regulators. The Drosophila RNA-binding protein brain tumor (Brat)
Hideyuki Komori +8 more
doaj +2 more sources
Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay [PDF]
Nature CommunicationsLegionella pneumophila, an intracellular bacterial pathogen, injects effector proteins into host cells to manipulate cellular processes and promote its survival and proliferation.
Yevgen Levdansky +8 more
doaj +2 more sources
Discovery of Drug-like Inhibitors of the Human Caf1/CNOT7 poly(A)-Selective Nuclease Using Compound Screening [PDF]
BiomoleculesThe human Ccr4–Not complex is a central regulator of post-transcriptional gene regulation, impacting on translation and mRNA degradation. In mRNA degradation, Ccr4–Not participates in the shortening of the mRNA poly(A)-tail via two catalytic subunits ...
Ishwinder Kaur +3 more
doaj +2 more sources
CNOT6L regulates energy metabolism in the ovarian granulosa cells associated with polycystic ovary syndrome [PDF]
Frontiers in Cell and Developmental BiologyThe endocrine functions exerted by ovarian granulosa cells (GCs) are crucial factors in maintaining follicle development, as oocyte development relies on providing energy substrates and cytokines by ovarian granulosa cells.
Shan Han +7 more
doaj +2 more sources
Preserving the Poly(A) Tail: Strategies Viruses Use to ‘CYA’ (Cover Your A’s) [PDF]
VirusesThe poly(A) tail on viral mRNAs plays an important role in gene expression, given the role of the 3′ mRNA tail in mRNA stability and translation. Viruses have developed several strategies to maintain the integrity of their poly(A) tails.
Jeffrey Wilusz
doaj +2 more sources
Insulin-Degrading Enzyme Regulates mRNA Processing and May Interact with the CCR4-NOT Complex [PDF]
CellsInsulin-degrading enzyme is a zinc metalloprotease that degrades low-molecular-weight substrates, including insulin. Ubiquitous expression, high evolutionary conservation, upregulation of Ide in stress situations, and literature findings suggest a ...
Barbara Bertocci +6 more
doaj +2 more sources
Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease [PDF]
MoleculesThe Caf1/CNOT7 nuclease is a catalytic component of the Ccr4-Not deadenylase complex, which is a key regulator of post-transcriptional gene regulation. In addition to providing catalytic activity, Caf1/CNOT7 and its paralogue Caf1/CNOT8 also contribute a
Ishwinder Kaur +3 more
doaj +2 more sources
Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes [PDF]
Nature CommunicationsOocyte in vitro maturation is a technique in assisted reproductive technology. Thousands of genes show abnormally high expression in in vitro maturated metaphase II (MII) oocytes compared to those matured in vivo in bovines, mice, and humans.
Yusheng Liu +11 more
doaj +2 more sources
Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex
Frontiers in Cell and Developmental Biology, 2023 Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation.
Lorenzo Pavanello +2 more
doaj +1 more source
RNF219 regulates CCR4-NOT function in mRNA translation and deadenylation
Scientific Reports, 2022 Post-transcriptional regulatory mechanisms play a role in many biological contexts through the control of mRNA degradation, translation and localization.
Aude Guénolé +7 more
doaj +1 more source