Results 91 to 100 of about 3,096 (155)
Cell Proliferation, Volume 58, Issue 3, March 2025.Construct postovulatory ageing protein map to deeply analyse the dynamic changes of postovulatory ageing proteins. DCP1A accumulation accelerates maternal mRNA decay in postovulatory‐aged oocytes. SPDL1 is crucial for maintaining spindle/chromosome structure and chromosome euploidy in PostOA oocytes.
Li Kong +10 more
wiley +1 more source
eLife, 2020 Carbon catabolite repression 4 (CCR4) is a conserved mRNA deadenylase regulating posttranscriptional gene expression. However, regulation of CCR4 in virus infections is less understood.
Zhen-Jia Zhang +13 more
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Cell Reports, 2017 Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure proper
Rhonda L. McFleder +2 more
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PLoS Genetics, 2016 Accumulating evidence supports the role of an aberrant transcriptome as a driver of metastatic potential. Deadenylation is a general regulatory node for post-transcriptional control by microRNAs and other determinants of RNA stability.
Farhoud Faraji +6 more
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eLife, 2017 Histone H3 lysine 36 methylation (H3K36me) is thought to participate in a host of co-transcriptional regulatory events. To study the function of this residue independent from the enzymes that modify it, we used a ‘histone replacement’ system in ...
Michael P Meers +7 more
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mRNAs of plants and green algae lack the m7G cap‐1 structure
New Phytologist, Volume 246, Issue 2, Page 396-401, April 2025.
Chen Xiao +7 more
wiley +1 more source
Cell Reports, 2015 The central question in stem cell regulation is how the balance between self-renewal and differentiation is controlled at the molecular level. This study uses germline stem cells (GSCs) in the Drosophila ovary to demonstrate that the Drosophila CCR4 ...
Ziwen Fu +10 more
doaj +1 more source
NOC out the fat: A short review of the circadian deadenylase Nocturnin
Annals of Medicine, 2008 The circadian clock is a conserved internal timekeeping mechanism that controls many aspects of physiology and behavior via the rhythmic expression of many genes. One of these rhythmic genes, Nocturnin, encodes a deadenylase--a ribonuclease that specifically removes the poly(A) tails from mRNAs.
Nicholas, Douris, Carla B, Green
openaire +2 more sources
Structural and Biochemical Investigation of the Pan2-Pan3 Deadenylase Complex
, 2020 Almost all mature eukaryotic mRNAs contain a 3′ polyadenosine (poly(A)) tail, which promotes nuclear export of mRNAs, protects transcripts from exonucleolytic decay, and increases translation efficiency. As the poly(A) tail is involved in many steps of gene expression, its length is highly regulated.
openaire +1 more source
CAF1-knockout mice are more susceptive to lipopolysaccharide-induced acute lung injury
Journal of Inflammation Research, 2016 Jia-Xin Shi,1 Jia-Shu Li,1 Rong Hu,1 Xiao-Min Li,2 Hong Wang3 1Department of Respiratory Medicine, Lianyungang First People’s Hospital, Affiliated Hospital of Xuzhou Medical University, Affiliated Hospital of the Clinical Medical School of Nanjing ...
Shi JX, Li JS, Hu R, Li XM, Wang H
doaj