Results 101 to 110 of about 3,096 (155)

Nocturnin, a Deadenylase in Xenopus laevis Retina [PDF]

Current Biology, 2003
Baggs, Julie E, Green, Carla B
openaire   +1 more source

Regulation of the Drosophila transcriptome by Pumilio and the CCR4-NOT deadenylase complex

RNA
The sequence-specific RNA-binding protein Pumilio controls Drosophila development; however, the network of mRNAs that it regulates remains incompletely characterized. In this study, we utilize knockdown and knockout approaches coupled with RNA-Seq to measure the impact of Pumilio on the transcriptome of Drosophila cells in culture.
Rebecca J. Haugen, Catherine Barnier, Nathan D. Elrod, Hua Luo, Madeline K. Jensen, Ping Ji, Craig A. Smibert, Howard D. Lipshitz, Eric J. Wagner, P. Lydia Freddolino, Aaron C. Goldstrohm   +10 more
openaire   +2 more sources

Poly(A) tail regulation in stem cells and early development. [PDF]

Cell Regen
Miao X, Hu G.
europepmc   +1 more source

Human pumilio proteins use fuzzy multivalent hydrophobic interactions to recruit the CCR4-NOT deadenylase complex to repress mRNAs. [PDF]

J Biol Chem
Dunshee EB, Saladin BA, Turner DJ, Qiu C, Dutcher RC, Williams JG, Corbo J, Wolcott OR, Korte AJ, Haugen RJ, Tanaka Hall TM, Valkov E, Goldstrohm AC.   +12 more
europepmc   +1 more source

The CCR4-NOT complex: a multifaceted sensor of molecular signals instructing eukaryotic mRNA translation and stability. [PDF]

Nucleic Acids Res
Caulier G, Siblini J, Sène L, Mauxion F, Séraphin B.   +4 more
europepmc   +1 more source

The CCR4-NOT deadenylase complex mediates tubulin autoregulation <i>via</i> specific adapters CNOT10 and CNOT11. [PDF]

MicroPubl Biol
Sarbanes SL, Hogg JR, Roll-Mecak A.
europepmc   +1 more source

The CCR4–NOT Deadenylase Complex Maintains Adipocyte Identity

The CCR4–NOT Deadenylase Complex Maintains Adipocyte Identity
Shortening of poly(A) tails triggers mRNA degradation; hence, mRNA deadenylation regulates many biological events. In the present study, we generated mice lacking the Cnot1 gene, which encodes an essential scaffold subunit of the CCR4–NOT deadenylase complex in adipose tissues (Cnot1-AKO mice) and we examined the role of CCR4–NOT in adipocyte function.
openaire  

Cytoplasmic poly-adenosine binding proteins modulate susceptibility of mRNAs to Pumilio-mediated decay. [PDF]

Nucleic Acids Res
McKenney KM, Hernandez-Perez C, Dunshee EB, Pum JM, DesMarais AJ, Connacher RP, Goldstrohm AC.   +6 more
europepmc   +1 more source

RNA triple helix assembled by the poly(A) tail enhances retrotransposon mobilization by preventing RNA deadenylation. [PDF]

Proc Natl Acad Sci U S A
Li H, Wang L, Lei Z, Biacsi AS, Jeong DH, Cho J.   +5 more
europepmc   +1 more source

Auxin-induced depletion of human CCR4-NOT subunits reveals opposing functions of CNOT1 and CNOT4 in mRNA metabolism. [PDF]

J Biol Chem
Kulkarni S, Smith C, Akinniyi OT, Giardine BM, Keller CA, Arnaoutov A, Reese JC.   +6 more
europepmc   +1 more source