Results 41 to 50 of about 3,096 (155)
CUG-BP binds to RNA substrates and recruits PARN deadenylase [PDF]
RNA, 2006 CUG-BP is the human homolog of the Xenopus EDEN-BP, which was shown previously to bind to mRNAs, such as c-mos, that exhibit rapid deadenylation following fertilization of the oocyte. While several studies have focused on roles of CUG-BP as a splicing or translation regulator in mammalian cells, its role in mRNA decay has not been examined in detail ...
Karen C M, Moraes +2 more
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An Unconventional Human Ccr4-Caf1 Deadenylase Complex in Nuclear Cajal Bodies [PDF]
Molecular and Cellular Biology, 2007 mRNA deadenylation is a key process in the regulation of translation and mRNA turnover. In Saccharomyces cerevisiae, deadenylation is primarily carried out by the Ccr4p and Caf1p/Pop2p subunits of the Ccr4-Not complex, which is conserved in eukaryotes including humans.
Eileen, Wagner +2 more
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PLoS ONE, 2012 The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that are characterised by a conserved BTG domain.
Rachel Doidge +3 more
doaj +1 more source
Role of Circadian Deadenylase Nocturnin in the Mitochondria
The FASEB Journal, 2018 The circadian rhythm is an evolutionarily conserved process that drives rhythmic behavior and physiology with a period of approximately 24 hours. Circadian rhythms are generated by the heterodimeric transcription factors CLOCK/BMAL1. CLOCK/BMAL1 binds to E‐boxes across the genome and drives the transcription of many genes, including their own ...
Anne Ojo, Isara Laothamatas, Carla Green
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eLife, 2022 Accurate control of the cell cycle is critical for development and tissue homeostasis, and requires precisely timed expression of many genes. Cell cycle gene expression is regulated through transcriptional and translational control, as well as through ...
Lenno Krenning +2 more
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Cell Reports, 2015 Eukaryotic mRNA degradation often initiates with the recruitment of the CCR4-NOT deadenylase complex and decay factors to the mRNA 3′ terminus. How the 3′-proximal decay machinery interacts with the 5′-terminal cap structure in order to engender mRNA ...
Tamiko Nishimura +6 more
doaj +1 more source
Breaking the A chain: regulating mRNAs in development through CCR4 deadenylase [PDF]
F1000 Biology Reports, 2009 Post-transcriptional mechanisms of gene regulation have long been implicated in specifying embryonic pattern in many organisms. Experiments in Caenorhabditis elegans, Drosophila, and Xenopus have recently converged, pointing to the CCR4 deadenylase complex as a key effector that modulates the expression of proteins from specific germline mRNAs.
Moore, Jocelyn, Lasko, Paul
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A mutation in cnot8, component of the Ccr4-not complex regulating transcript stability, affects expression levels of developmental regulators and reveals a role of Fgf3 in development of caudal hypothalamic dopaminergic neurons. [PDF]
PLoS ONE, 2014 While regulation of the activity of developmental control genes at the transcriptional level as well as by specific miRNA-based degradation are intensively studied, little is known whether general cellular mechanisms controlling mRNA decay may contribute
Peter Koch +2 more
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curledEncodes the Drosophila Homolog of the Vertebrate Circadian Deadenylase Nocturnin [PDF]
Genetics, 2009 AbstractDrosophila melanogaster curled, one of the first fly mutants described by T. H. Morgan >90 years ago, is the founding member of a series of curled wing phenotype mutants widely used as markers in fruit fly genetics. The expressivity of the wing phenotype is environmentally modulated, suggesting that the mutation affects the metabolic ...
Grönke, S. +4 more
openaire +3 more sources
New roles for nuclear EGFR in regulating the stability and translation of mRNAs associated with VEGF signaling. [PDF]
PLoS ONE, 2017 Cell membrane-associated epidermal growth factor receptor (EGFR) translocates into a perinuclear/nuclear location upon stimulation, where it complexes with mRNAs.
Klaus Dittmann +4 more
doaj +1 more source