Results 61 to 70 of about 3,096 (155)

Role of Tristetraprolin in the Resolution of Inflammation

Biology, 2021
Inflammation is a crucial part of immune responses towards invading pathogens or tissue damage. While inflammatory reactions are aimed at removing the triggering stimulus, it is important that these processes are terminated in a coordinate manner to ...
Peter Rappl, Bernhard Brüne, Tobias Schmid   +2 more
doaj   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation

Nature Communications, 2016
BTG2 promotes mRNA poly(A) tail shortening and regulates cellular differentiation. Here, Stupfler et al. show that the BTG2 APRO domain interacts with PABPC1 RRM1, allowing the former to recruit and stimulate the poly(A) tail shortening activity of CAF1 ...
Benjamin Stupfler, Catherine Birck, Bertrand Séraphin, Fabienne Mauxion   +3 more
doaj   +1 more source

A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity [PDF]

Nucleic Acids Research, 2013
Abstract In eukaryotic cells, the shortening and removal of the poly(A) tail of cytoplasmic mRNA by deadenylase enzymes is a critical step in post-transcriptional gene regulation. The ribonuclease activity of deadenylase enzymes is attributed to either a DEDD (Asp-Glu-Asp-Asp) or an endonuclease–exonuclease–phosphatase domain.
Maryati, Marayti, Kaur, Ishwinder, Jadhav, Gopal P., Olotu-Umoren, Loyin, Oveh, Blessing, Hashmi, Lubna, Fischer, Peter M., Winkler, G. Sebastiaan   +7 more
openaire   +3 more sources

The Circadian Transcription Factor CLOCK Modulates Oxidative Stress Resistance via the ACHL–Relish Axis in Drosophila

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study identifies the circadian transcription factor CLOCK (CLK) as a key regulator of oxidative stress resistance in fruit flies. CLK controls immune responses by driving rhythmic transcription of an RNA‐binding protein‐Achilles (ACHL) in the fly brain, which post‐transcriptionally represses the NF‐κB homolog Relish, limiting immune activation and
Xu Liu, Jiajia Fang, Dawei Cheng, Wei Luan, Yan Lv, Wen Hu, Lei Pan, Yong Zhang   +7 more
wiley   +1 more source

Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells

Biology Open, 2014
NANOS2 and NANOS3 belong to the Nanos family of proteins that contain a conserved zinc finger domain, which consists of two consecutive CCHC-type zinc finger motifs, and contribute to germ cell development in mice.
Atsushi Suzuki, Yuki Niimi, Yumiko Saga
doaj   +1 more source

The eIF4E-binding protein Eap1p functions in Vts1p-mediated transcript decay. [PDF]

PLoS ONE, 2012
Sequence-specific RNA binding proteins can induce the degradation of mRNAs through their ability to recruit proteins that trigger transcript destabilization. For example, Vts1p, the S.
Laura M Rendl, Melissa A Bieman, Heli K Vari, Craig A Smibert   +3 more
doaj   +1 more source

Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Lactylation of ENO1 reduced the binding of TRIM21 mRNA to ENO1, thereby preventing mRNA degradation. Elevated TRIM21 subsequently binds to VE‐Cadherin, promoting its ubiquitination. Targeting the lactylation of ENO1 with a specific inhibitory peptide alleviated endothelial dysfunction.
Xueru Xie, Tingyan Liu, Caiyan Zhang, Ye Cheng, Yajing Gao, Wenfeng Xiao, Haiyan Guo, Yutong Zhou, Yawei Yu, Kexin Wang, Yinghong Lin, Lisheng Xiao, Yingying Zhang, Weiguo Yang, Gangfeng Yan, Guoping Lu, Yufeng Zhou   +16 more
wiley   +1 more source

Genome-Wide Mapping of Decay Factor–mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4

G3: Genes, Genomes, Genetics, 2018
The Ccr4 (carbon catabolite repression 4)-Not complex is a major regulator of stress responses that controls gene expression at multiple levels, from transcription to mRNA decay.
Jason E. Miller, Liye Zhang, Haoyang Jiang, Yunfei Li, B. Franklin Pugh, Joseph C. Reese   +5 more
doaj   +1 more source

From the Understanding of Maternal Molecules and Mechanisms to Predicting Embryonic Development

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Background Embryo quality is a critical determinant of successful outcomes in assisted reproductive technology (ART). Various molecular and cellular mechanisms in oocytes influence embryo quality, and their understanding can lead to the establishment of selection criteria for enhancing implantation rates. Methods This review summarizes current
Yubao Wei, Akihiro Inoue, Kei Miyamoto
wiley   +1 more source