Results 71 to 80 of about 3,096 (155)
PLoS Genetics, 2012 PARN is one of several deadenylase enzymes present in mammalian cells, and as such the contribution it makes to the regulation of gene expression is unclear.
Jerome E Lee +5 more
doaj +1 more source
Role of the Citrus sinensis RNA deadenylase CsCAF1 in citrus canker resistance [PDF]
Molecular Plant Pathology, 2019 Summary Poly(A) tail shortening is a critical step in messenger RNA (mRNA) decay and control of gene expression. The carbon catabolite repressor 4 (CCR4)‐associated factor 1 (CAF1) component of the CCR4‐NOT deadenylase complex plays an essential role in mRNA deadenylation in most eukaryotes.
Hugo Massayoshi Shimo +6 more
openaire +2 more sources
Cell Proliferation, Volume 59, Issue 1, January 2026.Mutations in the RING finger domain (C3HC4) of RNF219 promote the formation of RNF219 condensates, which are able to encapsulate the CCR4‐NOT complex. These RNF219Mut‐CCR4‐NOT condensates reduce the deacetylation activity of the CCR4‐NOT complex and induce cell proliferation.
Chen Chen +4 more
wiley +1 more source
Nature Communications, 2018 The RNA-binding protein MARF1 is required for post-transcriptional regulation of mRNAs during mouse oogenesis. Here, by analyzing a Drosophila MARF1 mutant, the authors show that MARF1 recruits CCR4-NOT deadenylase to shorten the poly-A tails of target ...
Li Zhu +3 more
doaj +1 more source
Translational control in plants: from basic mechanisms to environmental and developmental responses
The Plant Journal, Volume 125, Issue 1, January 2026.SUMMARY Protein synthesis is an essential process for all living organisms and is tightly regulated to ensure the proper production of proteins needed for growth, development, and stress responses. As sessile organisms, plants have evolved distinct mechanisms to regulate translation, allowing them to adapt to their environment.
Jade Lyons +3 more
wiley +1 more source
CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner
RNA Biology, 2022 Circadian clocks are an endogenous internal timekeeping mechanism that drives the rhythmic expression of genes, controlling the 24 h oscillatory pattern in behaviour and physiology.
Haytham Mohamed Aly Mohamed +6 more
doaj +1 more source
Structural basis for inhibition of the deadenylase activity of human
FEBS Letters, 2016 Human CNOT6L/CCR4, a member of the endonuclease‐exonuclease‐phosphatase (EEP) family enzymes, is one of the two deadenylase enzymes in the conserved CCR4‐NOT complex. Here, we report inhibitor‐bound crystal structures of the human CNOT6L nuclease domain in complex with the nucleotide CMP and the aminoglycoside neomycin. Deadenylase activity assays show
Qionglin Zhang +7 more
openaire +2 more sources
m6A RNA Modification Controls HTLV‐1 Tax and Host Gene Expression
Genes to Cells, Volume 30, Issue 6, November 2025.Our study shows that m6A regulation is critical for controlling HTLV‐1, shaping both viral transcripts and host gene programs, thereby illuminating latency mechanisms and suggesting tractable targets for therapy and prevention. ABSTRACT Human T‐cell Leukemia Virus Type 1 (HTLV‐1) is a pathogenic human retrovirus that is responsible for intractable ...
Rei Gibu +5 more
wiley +1 more source
Anti‐proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase [PDF]
The EMBO Journal, 2011 Tob is a member of the anti-proliferative protein family, which functions in transcription and mRNA decay. We have previously demonstrated that Tob is involved in the general mechanism of mRNA decay by mediating mRNA deadenylation through interaction with Caf1 and a general RNA-binding protein, PABPC1.
Nao, Hosoda +8 more
openaire +2 more sources
NamiRNA‐Enhancer Network: The Changing Era Challenge and Chance of miRNA
Advanced Science, Volume 12, Issue 39, October 20, 2025.MiRNAs (miRNAs) regulate diverse biological processes across species. Unlike canonical miRNA‐mediated gene repression, Nuclear Activating miRNAs (NamiRNAs) can efficiently upregulate gene expression by targeting enhancers. This review systematically summarizes recent advances in NamiRNA research, elucidates the theory of NamiRNA‐Enhancer‐mediated Gene ...
Lu Chen +13 more
wiley +1 more source