Results 101 to 110 of about 14,150 (193)
Deciphering mRNA Translation During Sperm Capacitation: A New Frontier in Fertility Research
Molecular Reproduction and Development, Volume 93, Issue 2, February 2026.ABSTRACT Male infertility accounts for approximately 50% of infertility cases, with nearly 30% remaining unexplained after standard evaluations. This highlights the need for a better understanding of sperm function to advance diagnostic and therapeutic strategies. Sperm were long considered translationally quiescent; however, emerging evidence suggests
Saurabh Tiwari +2 more
wiley +1 more source
Critical role of deadenylation in regulating poly(A) rhythms and circadian gene expression.
PLoS Computational Biology, 2020 The mammalian circadian clock is deeply rooted in rhythmic regulation of gene expression. Rhythmic transcriptional control mediated by the circadian transcription factors is thought to be the main driver of mammalian circadian gene expression.
Xiangyu Yao, Shihoko Kojima, Jing Chen
doaj +1 more source
A deadenylase assay by size-exclusion chromatography. [PDF]
PLoS ONE, 2012 The shortening of the 3'-end poly(A) tail, also called deadenylation, is crucial to the regulation of mRNA processing, transportation, translation and degradation.
Guang-Jun He, Yong-Bin Yan
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RNA Analysis Uncovers Pathogenic PARN Variant in Dyskeratosis Congenita
Clinical Genetics, Volume 109, Issue 2, Page 346-351, February 2026.Using WGS and RNA analysis, we identified a branch point‐disrupting variant in the PARN gene and elucidated its pathogenic molecular mechanism in a child with atypical dyskeratosis congenita presentation. ABSTRACT Dyskeratosis congenita (DC) is a rare genetic disorder caused by impaired telomere maintenance, leading to diverse clinical manifestations ...
Daria Akimova +3 more
wiley +1 more source
Control of mRNA metabolism by deadenylation
The FASEB Journal, 2013 The presence of a polyadenosine tail is an important determinant of mRNA translation and stability. The regulated removal of the tail, i.e. deadenylation, leads to either translational quiescence or mRNA degradation. Deadenylation, therefore, is a critical node in gene expression and is especially important in certain biological contexts such as in the
Jeff Coller +5 more
openaire +1 more source
Novel roles of the multifunctional CCR4-NOT complex in post-transcriptional regulation
Frontiers in Genetics, 2014 The CCR4-NOT complex is highly conserved gene silencer, and more general functions of the complex have been elucidated at post-transcriptional levels. Specific regulatory proteins, including miRNA-induced silencing complex and its associate protein, bind
Toshifumi eInada, Shiho eMakino
doaj +1 more source
Protecting the proteome: Eukaryotic cotranslational quality control pathways. [PDF]
, 2014 The correct decoding of messenger RNAs (mRNAs) into proteins is an essential cellular task. The translational process is monitored by several quality control (QC) mechanisms that recognize defective translation complexes in which ribosomes are stalled on
Bennett, Eric J, Lykke-Andersen, Jens
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CUP promotes deadenylation and inhibits decapping of mRNA targets [PDF]
Genes & Development, 2011 CUP is an eIF4E-binding protein (4E-BP) that represses the expression of specific maternal mRNAs prior to their posterior localization. Here, we show that CUP employs multiple mechanisms to repress the expression of target mRNAs. In addition to inducing translational repression, CUP maintains mRNA targets in a repressed state by promoting their ...
Igreja, C., Izaurralde, E.
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eLife, 2019 The Ccr4-Not complex removes mRNA poly(A) tails to regulate eukaryotic mRNA stability and translation. RNA-binding proteins contribute to specificity by interacting with both Ccr4-Not and target mRNAs, but this is not fully understood.
Michael W Webster +2 more
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From the Understanding of Maternal Molecules and Mechanisms to Predicting Embryonic Development
Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.ABSTRACT Background Embryo quality is a critical determinant of successful outcomes in assisted reproductive technology (ART). Various molecular and cellular mechanisms in oocytes influence embryo quality, and their understanding can lead to the establishment of selection criteria for enhancing implantation rates. Methods This review summarizes current
Yubao Wei, Akihiro Inoue, Kei Miyamoto
wiley +1 more source