Results 111 to 120 of about 14,150 (193)
Nature Communications, 2020 The CCR4-NOT complex catalyzes mRNA deadenylation and hence regulates protein translation. Here the authors show that CNOT3 regulation of this complex is needed for positive selection of thymocytes via a mechanism involving inhibition of pro-apoptotic ...
Taku Ito-Kureha +13 more
doaj +1 more source
Molecular Microbiology, Volume 125, Issue 1, Page 67-79, January 2026.A fully conserved 16mer motif is required in the silent VSG to trigger efficient silencing of the expression site (ES)‐resident VSG and a successful exchange of the VSG coat. ABSTRACT The variant surface glycoprotein (VSG) of African trypanosomes is essential for the survival of bloodstream form parasites.
Majeed Bakari‐Soale +4 more
wiley +1 more source
Translational control in plants: from basic mechanisms to environmental and developmental responses
The Plant Journal, Volume 125, Issue 1, January 2026.SUMMARY Protein synthesis is an essential process for all living organisms and is tightly regulated to ensure the proper production of proteins needed for growth, development, and stress responses. As sessile organisms, plants have evolved distinct mechanisms to regulate translation, allowing them to adapt to their environment.
Jade Lyons +3 more
wiley +1 more source
Maturation of selected human mitochondrial tRNAs requires deadenylation
eLife, 2017 Human mitochondria contain a genome (mtDNA) that encodes essential subunits of the oxidative phosphorylation system. Expression of mtDNA entails multi-step maturation of precursor RNA. In other systems, the RNA life cycle involves surveillance mechanisms, however, the details of RNA quality control have not been extensively characterised in human ...
Sarah F Pearce +8 more
openaire +4 more sources
HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA [PDF]
, 2017 The microRNA (miRNA)-mediated repression of protein synthesis in mammalian cells is a reversible process. Target mRNAs with regulatory AU-rich elements (AREs) in their 3′-untranslated regions (3′-UTR) can be relieved of miRNA repression under cellular ...
Bhattacharyya, Suvendra N. +4 more
core
Target RNAs strike back on MicroRNAs [PDF]
, 2018 MicroRNAs are extensively studied regulatory non-coding small RNAs that silence animal genes throughout most biological processes, typically doing so by binding to partially complementary sequences within target RNAs.
de la Mata, Manuel +3 more
core +1 more source
The Link Between Serum Copper and Diabetic Kidney Disease: A Plasma Proteomic Perspective
Journal of Diabetes Research, Volume 2026, Issue 1, 2026.Background Diabetic kidney disease (DKD) is a significant microvascular complication of diabetes, accounting for the majority of cases of end‐stage renal disease. Copper, an essential trace element, has been identified as a factor closely associated with the onset and progression of DKD.
Zhenbang Feng +8 more
wiley +1 more source
External and internal triggers of cell death in yeast [PDF]
, 2016 In recent years, yeast was confirmed as a useful eukaryotic model system to decipher the complex mechanisms and networks occurring in higher eukaryotes, particularly in mammalian cells, in physiological as well in pathological conditions.
FALCONE, Claudio, MAZZONI, Cristina
core +2 more sources
Analysis of mRNA deadenylation by multi-protein complexes
Methods, 2017 Poly(A) tails are found at the 3' end of almost every eukaryotic mRNA and are important for the stability of mRNAs and their translation into proteins. Thus, removal of the poly(A) tail, a process called deadenylation, is critical for regulation of gene expression. Most deadenylation enzymes are components of large multi-protein complexes.
Webster, Michael W. +3 more
openaire +3 more sources
The 5'-3' exoribonuclease pacman is required for epithelial sheet sealing in Drosophila and genetically interacts with the phosphatase puckered [PDF]
, 2008 Background information. Ribonucleases have been well studied in yeast and bacteria, but their biological significance to developmental processes in multicellular organisms is not well understood.
Browne, Cathy +7 more
core +2 more sources