Results 171 to 180 of about 14,150 (193)

Uridylation regulates mRNA decay directionality in fission yeast. [PDF]

Nat Commun
Grochowski M, Lipińska-Zubrycka L, Townsend S, Golisz-Mocydlarz A, Zakrzewska-Płaczek M, Brzyżek G, Jurković B, Świeżewski S, Ralser M, Małecki M.   +9 more
europepmc   +1 more source

Functions and mechanisms of RNA tailing by nucleotidyl transferase proteins in plants. [PDF]

Front Plant Sci
Chen J, Li X, Dong X, Wang X.
europepmc   +1 more source

Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma. [PDF]

Nat Commun
Galvan B, Ongena L, Bruyr J, Fettweis G, Lucarelli E, Lavergne A, Mariavelle E, O'Grady TM, Hassoun ZEO, Claes M, Dubois L, Lee KAW, Kruys V, Gueydan C, Durand J, Hervouet E, Geyer FH, Banito A, Imle R, Mao L, Jayavelu AK, Grünewald TGP, Cidre-Aranaz F, Twizere JC, Dequiedt F.   +24 more
europepmc   +1 more source

The molecular mechanisms underpinning maternal mRNA dormancy. [PDF]

Biochem Soc Trans
Lorenzo-Orts L, Pauli A.
europepmc   +1 more source

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Deadenylate or activate?

Science, 2020
Immunology When cells are quiescent, they undergo reversible cell cycle arrest and evince low basal metabolism. Naive T cells are normally quiescent until they recognize cognate antigens through T cell receptor–costimulatory molecule signaling. T cell quiescence appears to be an active process, but the mechanistic details are poorly understood.
openaire   +1 more source

Assaying mRNA Deadenylation In Vivo

2014
Deadenylation is the removal of poly(A) tails from mRNA. Here, we present two methods for assaying deadenylation in vivo. The first is a method for measuring bulk poly(A) tail lengths. When combined with a block in transcription, the method can be used for measuring the rate of bulk poly(A) tail shortening.
Claudia, Temme, Elmar, Wahle
openaire   +2 more sources

Assaying mRNA Deadenylation In Vitro

2014
Deadenylation is the removal of poly(A) tails from mRNA. This chapter presents two methods to assay deadenylation in vitro. The first is a quick and quantitative assay for the degradation of radiolabeled poly(A) that can easily be adapted to be used for many different enzymes.
Mandy, Jeske, Claudia, Temme, Elmar, Wahle   +2 more
openaire   +2 more sources

Deadenylation: enzymes, regulation, and functional implications

WIREs RNA, 2014
Lengths of the eukaryotic messenger RNA (mRNA) poly(A) tails are dynamically changed by the opposing effects of poly(A) polymerases and deadenylases. Modulating poly(A) tail length provides a highly regulated means to control almost every stage of mRNA lifecycle including transcription, processing, quality control, transport, translation, silence, and ...
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Translational capacity of deadenylated messenger RNA

Cell, 1974
Abstract In order to determine whether the functional capacity of polyadenylated messenger RNA is altered when the poly(A) segment is shortened as a consequence of mRNA aging, we compared the abilities of differentially labeled new and old mRNAs to engage ribosomes.
E. Bard, D. Efron, A. Marcus, R.P. Perry
openaire   +1 more source