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Translational capacity of deadenylated messenger RNA

Cell, 1974
Abstract In order to determine whether the functional capacity of polyadenylated messenger RNA is altered when the poly(A) segment is shortened as a consequence of mRNA aging, we compared the abilities of differentially labeled new and old mRNAs to engage ribosomes.
E. Bard, D. Efron, A. Marcus, R.P. Perry
openaire   +1 more source

Chapter 5 Regulated Deadenylation In Vitro

2008
The 3'-poly(A) tail, found on virtually all mRNAs, is enzymatically shortened by a process referred to as "deadenylation." Deadenylation is a widespread means of controlling mRNA stability and translation. The enzymes involved-so-called deadenylases-are surprisingly diverse. They are controlled by RNA sequences commonly found in 3'-untranslated regions
Aaron C. Goldstrohm   +2 more
openaire   +1 more source

RNA deadenylation complexes in development and diseases

Biochemistry and Cell Biology, 2023
Ly P Vu
exaly  

Integrative omics indicate FMRP sequesters mRNA from translation and deadenylation in human neuronal cells

Molecular Cell, 2022
Lynne E. Maquat   +2 more
exaly  

mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases

Molecular Cell, 2018
Jeff Coller   +2 more
exaly  

A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila

EMBO Journal, 2004
Martine Simonelig   +2 more
exaly  

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