Results 41 to 50 of about 14,150 (193)
The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs [PDF]
Open Biology, 2016 Once every menstrual cycle, eggs are ovulated into the oviduct where they await fertilization. The ovulated eggs are arrested in metaphase of the second meiotic division, and only complete meiosis upon fertilization. It is crucial that the maintenance of
Michał Pasternak +3 more
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Deadenylation—a piece of
The EMBO Journal, 2014 Pan is a poly(A)‐specific 3′ exoribonuclease that, together with the CCR4‐NOT complex, is responsible for initiating and controlling mRNA decay by degradation of the poly(A) tail. Now, more than twenty years after the enzyme's discovery, a surge of recent papers, including one in this issue of The EMBO Journal (Wolf et al, ) has revealed details of its
Milton T, Stubbs, Elmar, Wahle
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Rous Sarcoma Virus RNA Stability Element Inhibits Deadenylation of mRNAs with Long 3′UTRs
Viruses, 2017 All retroviruses use their full-length primary transcript as the major mRNA for Group-specific antigen (Gag) capsid proteins. This results in a long 3′ untranslated region (UTR) downstream of the termination codon. In the case of Rous sarcoma virus (RSV),
Vidya Balagopal, Karen L. Beemon
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Traffic into silence: endomembranes and post-transcriptional RNA silencing. [PDF]
, 2014 microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-
Chen, Xuemei +2 more
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Deadenylation of mRNA by the CCR4-NOT complex in Drosophila: molecular and developmental aspects
Frontiers in Genetics, 2014 Controlled shortening of the poly(A) tail of mRNAs is the first step in eukaryotic mRNA decay and can also be used for translational inactivation of mRNAs.
Claudia eTemme +2 more
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Cells, 2020 Translation is spatiotemporally regulated and endoplasmic reticulum (ER)-associated mRNAs are generally in efficient translation. It is unclear whether the ER-associated mRNAs are deadenylated or degraded on the ER surface in situ or in the cytosol. Here,
Tian-Li Duan +3 more
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Molecular Insights into mRNA Polyadenylation and Deadenylation
International Journal of Molecular Sciences, 2022 Poly(A) tails are present on almost all eukaryotic mRNAs, and play critical roles in mRNA stability, nuclear export, and translation efficiency. The biosynthesis and shortening of a poly(A) tail are regulated by large multiprotein complexes. However, the molecular mechanisms of these protein machineries still remain unclear.
Junjie Liu +4 more
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HPat a decapping activator interacting with the miRNA effector complex.
PLoS ONE, 2013 Animal miRNAs commonly mediate mRNA degradation and/or translational repression by binding to their target mRNAs. Key factors for miRNA-mediated mRNA degradation are the components of the miRNA effector complex (AGO1 and GW182) and the general mRNA ...
Elisabeth Barišić-Jäger +4 more
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Mitochondrial dysfunction reveals the role of mRNA poly(A) tail regulation in oculopharyngeal muscular dystrophy pathogenesis. [PDF]
PLoS Genetics, 2015 Oculopharyngeal muscular dystrophy (OPMD), a late-onset disorder characterized by progressive degeneration of specific muscles, results from the extension of a polyalanine tract in poly(A) binding protein nuclear 1 (PABPN1).
Aymeric Chartier +18 more
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Open Biology, 2023 Alpha-synuclein (SNCA) accumulation plays a central role in the pathogenesis of Parkinson's disease. Determining and interfering with the mechanisms that control SNCA expression is one approach to limiting disease progression.
Fedon-Giasin Kattan +4 more
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