Results 61 to 70 of about 32,113 (291)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The regulatory mechanism of deferoxamine spray in promoting the healing of chronic wounds in third-degree burns

Yixue xinzhi zazhi
Objective To explore the effects and its mechanism of deferoxamine spray on the healing process of chronic wounds from third-degree burns. Methods Screening the concentration of deferoxamine spray suitable for subsequent experiments through ...
CHAI Langjie, LI Qin, GUO Liang, HUANG Jianglong   +3 more
doaj   +1 more source

Ferritin‐Doped Nanoparticles Triggered Tumor‐Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation

Advanced Healthcare Materials, EarlyView.
Ferritin‐doped hybrid nanoparticles triggered accurate tumor‐specific hemorrhage for enhanced in situ photothermal therapy and evoked anti‐tumor immunity. Notably, HFn/GA‐Fe specifically induced tumor hemorrhage 12 h after intravenous injection, resulting in visible color darkening. Through photoacoustic imaging, tumor vessels could be clearly observed
Haidong Zha, Xiao Liang, Long Xi, Jiamao Chen, Wenzhao Zhong, Zhen Yuan, Meng Xu, Ying Zheng   +7 more
wiley   +1 more source

A Re-evaluation of Electron-Transfer Mechanisms in Microbial Electrochemistry: Shewanella Releases Iron that Mediates Extracellular Electron Transfer [PDF]

, 2016
Exoelectrogenic bacteria can couple their metabolism to extracellular electron acceptors, including macroscopic electrodes, and this has applications in energy production, bioremediation and biosensing.
Artyushkova, Baron, Breuer, Carmona-Martinez, Chourey, Clarke, Cornejo, Coursolle, Du, D′Souza, Emde, Firer-Sherwood, Firer-Sherwood, Golitsch, Hartshorne, Hau, Kotloski, Logan, Lower, Luo, Malvankar, Marsili, Meitl, Okamoto, Okamoto, Peng, Pirbadian, Rabaey, Roy, Roy, Shi, Singh, Stamou, Worrall   +33 more
core   +1 more source

The Availability of Iron Is Involved in the Murine Experimental Toxoplasma gondii Infection Outcome

Microorganisms, 2020
Iron is an important constituent of our environment, being necessary for both mammalian and pathogenic protozoa survival. Iron-containing proteins exert a wide range of biological processes such as biodegradation and biosynthesis, as well as immune ...
Mário Cézar Oliveira, Loyane Bertagnolli Coutinho, Marcos Paulo Oliveira Almeida, Marisol Pallete Briceño, Ester Cristina Borges Araujo, Neide Maria Silva   +5 more
doaj   +1 more source

Perturbed angular correlation study of a haptenic molecule [PDF]

, 1972
The angular correlation of the 173-247 keV gamma-ray cascade after the electron-capture decay of (111)In is strongly perturbed when the I-p-nitrophenylethylenediaminetetraacetate chelate of (111)In(3+) is added to a solution containing rabbit antibody ...
Baldeschwieler, John D., Meares, Claude F., Sundberg, Michael W.   +2 more
core  

Mechanisms of cell injury by activated oxygen species. [PDF]

, 1994
Current evidence suggests that O2- and H2O2 injure cells as a result of the generation of a more potent oxidizing species. In addition to O2- and H2O2, the third essential component of the complex that mediates the lethal cell injury is a cellular source
Farber, John L.
core   +2 more sources

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

A Novel Star Like Eight-Arm Polyethylene Glycol-Deferoxamine Conjugate for Iron Overload Therapy

Pharmaceutics, 2020
The traditional iron chelator deferoxamine (DFO) has been widely used in the treatment of iron overload disease. However, DFO has congenital disadvantages, including a very short circular time and non-negligible toxicity.
Bohong Yu, Yinxian Yang, Qi Liu, Aiyan Zhan, Yang Yang, Hongzhuo Liu   +5 more
doaj   +1 more source

Rational Design of Optical Single‐Walled Carbon Nanotube‐Based Nanosensors with Biological Recognition Elements

Advanced Sensor Research, EarlyView.
This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan, Atara Israel, Maria Celina Stefoni, Catarina Ferraz, Ryan M. Williams   +4 more
wiley   +1 more source