Delphinidin and Its Glycosides’ War on Cancer: Preclinical Perspectives [PDF]
International Journal of Molecular Sciences, 2021 Until now, several studies have looked at the issue of anthocyanin and cancer, namely the preventive and inhibitory effects of anthocyanins, as well as the underlying molecular processes. However, no targeted review is available regarding the anticarcinogenic effects of delphinidin and its glycosides on various cancers and their plausible molecular ...
Hae-Jeung Lee
exaly +3 more sources
Cytotoxic effects of delphinidin in human osteosarcoma cells
Acta Orthopaedica et Traumatologica Turcica, 2018 Introduction: The aim of this study was to evaluate whether delphinidin is cytoprotective or cytotoxic in osteosarcoma cell lines, and to elucidate the underlying mechanisms.
Dong-Yeong Lee +5 more
doaj +3 more sources
Targeting cancer with delphinidin: from molecular insights to therapeutic implications [PDF]
Frontiers in PharmacologyDelphinidin is a natural anthocyanidin abundant in various fruits, vegetables, and flowers. It has garnered significant attention due to its potent antioxidant activity and extensive anticancer potential.
Yuhong Xu +5 more
doaj +2 more sources
Delphinidin upregulates microRNA-let-7b expression through family with sequence similarity 222 member B [PDF]
Scientific ReportsDelphinidin is a major anthocyanidin belonging to the flavonoid family with pharmacological activities against cancer, inflammation, and muscle atrophy. However, the mechanism regulating its activity is yet to be completely elucidated.
Motoki Murata +7 more
doaj +2 more sources
Breast Cancer: Basic and Clinical Research, 2011 Delphinidin is a polyphenolic compound found in many brightly colored fruits and vegetables. Delphinidin is also the major bioactive component found in many dietary supplements that are currently consumed as complementary cancer medicine including ...
Tuba Ozbay, Rita Nahta
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Delphinidin attenuates cognitive deficits and pathology of Alzheimer’s disease by preventing microglial senescence via AMPK/SIRT1 pathway [PDF]
Alzheimer’s Research & TherapyBackground Emerging evidence suggests that senescent microglia play a role in β-amyloid (Aβ) pathology and neuroinflammation in Alzheimer’s disease (AD).
Ying Liu +6 more
doaj +2 more sources
Delphinidin Exerts Immunomodulatory Effects in Canine Neutrophils and Peripheral Blood Mononuclear Cells by Limiting Tissue Damaging Mechanisms and Regulating Cytokine Responses [PDF]
AnimalsDogs can develop chronic inflammatory diseases that induce progressive tissue damage and illness. Delphinidin is a component of maqui (Aristotelia chilensis) and has anti-inflammatory and antioxidant effects.
Alejandra I. Hidalgo +5 more
doaj +2 more sources
Delphinidin modulates neuroinflammation and behavioral deficits in a Parkinson's disease mouse model. [PDF]
NPJ Parkinsons DisAbstract Neuroinflammation is deeply intertwined with dopaminergic (DA) neurodegeneration in Parkinson’s disease (PD). We tested whether delphinidin, an anthocyanidin with reported inflammasome/NF-κB modulatory activity, alters neuroinflammation and nigrostriatal integrity in a progressive AAV1/2-A53T α-synuclein (
Grotemeyer A +10 more
europepmc +5 more sources
In-Depth Exploration of the Coloration Mechanism of Iris dichotoma Pall. via Transcriptomic and Metabolomic Analyses [PDF]
PlantsIris dichotoma Pall., renowned for its high ornamental value, is frequently cultivated in flowerbeds and courtyards, endowing garden landscapes with unique allure. Dark-hued flowers are widely regarded as more aesthetically appealing. This study utilized
Yalin Yu +4 more
doaj +2 more sources
Effect of maqui-berry extract in dry eye disease – A clinical and molecular analysis
Indian Journal of Ophthalmology, 2023 Purpose: This study aims to investigate the effects of maqui-berry extract (MBE) in improving signs and symptoms of dry eye disease (DED) along with ocular surface inflammation in patients with DED.
Gairik Kundu +5 more
doaj +1 more source