Results 71 to 80 of about 8,483 (198)

Mucopolysaccharidosis type I - Clinical and genetic characteristics of Romanian patients

Romanian Journal of Laboratory Medicine, 2020
Background: Mucopolysaccharidosis type I (MPS I) is an autosomal recessive lysosomal storage disorder caused by a deficiency of α-L-iduronidase (IDUA), which leads to the accumulation of partially digested glycosaminoglycans (dermatan sulfate and heparan
Alkhzouz Camelia, Lazea Cecilia, Miclea Diana, Asavoaie Carmen, Nascu Ioana, Pop Tudor, Grigorescu-Sido Paula   +6 more
doaj   +1 more source

Navigating infection by pathogenic spirochetes: The host‐bacteria interface at the atomic level

Protein Science, Volume 34, Issue 7, July 2025.
Abstract Pathogenic spirochetes bind and interact with various host structures and molecules throughout the course of infection. By utilizing their outer surface molecules, spirochetes can effectively modulate their dissemination, interact with immune system regulators, and select specific destination niches within the host.
Libor Hejduk, Norbert Müller, Adriana Rathner, Ján Štěrba, Shang‐Cheng Hung, Chia‐Lin Chyan, Ryan O. M. Rego, Martin Strnad   +7 more
wiley   +1 more source

Real World Case Series: A.G.E. Interrupter Ultra Serum

Journal of Cosmetic Dermatology, Volume 24, Issue S3, July 2025.
ABSTRACT Background The A.G.E. Interrupter serum has been developed in an oil‐in‐water emulsion to contain 30% proxylane, Cassia alata extract, blueberry and pomegranate extract, rhamnose, and gentiana lutea root extract. The technology has several patent ingredients as well as synergistic patents with proxylane, rhamnose, and new ones submitted for ...
Sonya Abdulla, Patricia Brieva, Hugues Cartier, Christine Dierickx, Sophie Guénin, Ariel Haus, Jani van Loghem, Ali Shahbaz, Nikolaus Schicher, Peter Bjerring   +9 more
wiley   +1 more source

Heterologous Surface Display Reveals Conserved Complement Inhibition and Functional Diversification of Borrelia burgdorferi Elp Proteins

Molecular Microbiology, Volume 124, Issue 1, Page 77-90, July 2025.
A novel approach using the Pseudomonas syringae ice nucleation protein (INP) system to present Borrelia burgdorferi lipoproteins on the surface of Escherichia coli reveals conservation of complement inhibitory functions among uncharacterized OspE/F‐like leader peptide (Elp) proteins.
Nathan Hill, Lara M. Matulina, Cameron MacIntyre, M. Amine Hassani, Sheila Thomas, Matteo Luban, Isabelle Ward, Amina Abdalla, John M. Leong, Brandon L. Garcia, Jacob E. Lemieux   +10 more
wiley   +1 more source

Arterial heparan sulfate is negatively associated with hyperglycemia and atherosclerosis in diabetic monkeys

Cardiovascular Diabetology, 2004
Background Arterial proteoglycans are implicated in the pathogenesis of atherosclerosis by their ability to trap plasma lipoproteins in the arterial wall and by their influence on cellular migration, adhesion and proliferation.
Litwak Kenneth N, Vogl-Willis Catherine A, Wagner Janice D, Edwards Iris J, Cefalu William T   +4 more
doaj   +1 more source

Recent Advances in Enzymes and Chemoenzymatic Synthesis of Tetrasaccharide Linkage Region of Proteoglycans

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
The tetrasaccharide linkage region of proteoglycans is synthesized through a series of well‐controlled enzymatic reactions in nature. The expression, activity, and substrate profile of these biosynthetic enzymes and the latest development of chemoenzymatic synthesis of linkage region‐bearing glycopeptides are summarized in this review.
Po‐han Lin, Xuefei Huang
wiley   +1 more source

Role of Biomarkers in Diagnosing Disease, Assessing the Severity and Progression of Disease, and Evaluating the Efficacy of Therapies

Journal of Inherited Metabolic Disease, Volume 48, Issue 3, May 2025.
ABSTRACT This paper reviews biomarkers in lysosomal disease according to their categories and definitions. There are numerous biomarkers in lysosomal diseases. Some are disease or organ‐specific, but most are not. Organ‐specific biomarkers are especially useful, but most biomarkers help with diagnosis, assessing disease severity, prognosis, and ...
Raphael Schiffmann
wiley   +1 more source

Formation of dermatan sulfate by cultured human skin fibroblasts. Effects of sulfate concentration on proportions of dermatan/chondroitin.

Journal of Biological Chemistry, 1986
[3H,35S]Dermatan/chondroitin sulfate glycosaminoglycans produced during culture of fibroblasts in medium containing varying concentrations of sulfate were tested for their susceptibility to chondroitin ABC lyase and chondroitin AC lyase. Chondroitin ABC lyase completely degraded [3H]hexosamine-labeled and [35S] sulfate-labeled dermatan/chondroitin ...
Donald E. Humphries, Mary E. Palmer, Cynthia K. Silbert, Jeremiah E. Silbert   +3 more
openaire   +3 more sources

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.
Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley   +1 more source

Comparative electron microscopic visualization of the lung alveolar epithelial glycocalyx with different staining and labeling methods

Journal of Anatomy, Volume 246, Issue 5, Page 770-781, May 2025.
Cytochemical staining by tissue massage and post‐embedding lectin labeling after vascular perfusion support 3R principles of animal welfare, by reducing the number of animals. These methods can be used routinely for assessing ultrastructural changes of the alveolar epithelial glycocalyx in experimental in vivo models under different physiological and ...
Vladimir Gluhovic, Sara Timm, Wolfgang M. Kuebler, Elena Lopez‐Rodriguez, Matthias Ochs   +4 more
wiley   +1 more source