Results 81 to 90 of about 418,629 (276)

Galactosaminoglycan Function and Oligosaccharide Structure Determination

The Scientific World Journal, 2007
This review will discuss the importance of sequencing long chondroitin sulfate and dermatan sulfate chains specifically derived from decorin. Decorin is a member of the small leucine-rich repeat proteoglycans and ubiquitously expressed primarily in the ...
Daniela G. Seidler, Jasna Peter-Katalinic, Alina D. Zamfir   +2 more
doaj   +1 more source

Collagens and proteoglycans of the corneal extracellular matrix

Brazilian Journal of Medical and Biological Research, 2003
The cornea is a curved and transparent structure that provides the initial focusing of a light image into the eye. It consists of a central stroma that constitutes 90% of the corneal depth, covered anteriorly with epithelium and posteriorly with ...
Y.M. Michelacci
doaj   +1 more source

Endothelial glycocalyx degradation during sepsis: Causes and consequences

Matrix Biology Plus, 2021
The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the vascular lumen. It is enriched in proteoglycans, which are proteins attached to the glycosaminoglycans heparan sulfate, chondroitin sulfate, dermatan sulfate ...
Ryan C. Sullivan, Matthew D. Rockstrom, Eric P. Schmidt, Joseph A. Hippensteel   +3 more
doaj   +1 more source

Differentiation of murine B cells induced by chondroitin sulfate B [PDF]

, 2008
A two-step culture system was used to investigate the role of chondroitin sulfate (CS) B, which is mitogenic to B cells, in differentiation of B cells. Mouse spleen B cells were incubated for 3 days with CSB in the presence of interleukin (IL)-4 and IL-5.
Aoyama, Calame, Carmassi, Castor, Chang, Clayton, Eiichi Gohda, Eriko Aoyama, Fruman, Guo, Hardingham, Hodgkin, Horikawa, Kawamoto, Kawashima, Kittlick, Leitges, Manjarrez-Orduño, Maruyama, Menozzi, Ming Zhong, Mitrovic, Murakami, Naujokas, Penc, Poole, Rachmilewitz, Rafi, Ritsuko Yoshihara, Rui, Saeko Kawai, Sanderson, Sedgwick, Shin, Sugahara, Suzuki, Taylor, Tomomi Goto, Toyama-Sorimachi, Trowbridge, Wang, Worral, Wyant, Yusuke Kadota   +43 more
core   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Dermatan sulfate reduces monocyte chemoattractant protein 1 and TGF-β production, as well as macrophage recruitment and myofibroblast accumulation in mice with unilateral ureteral obstruction

Brazilian Journal of Medical and Biological Research, 2011
Selectins play an essential role in most inflammatory reactions, mediating the initial leukocyte-rolling event on activated endothelium. Heparin and dermatan sulfate (DS) bind and block P- and L-selectin function in vitro.
C.L.R. Belmiro, R.G. Gonçalves, E.O. Kozlowski, A.F. Werneck, C.M. Takyia, M. Leite-Jr., M.S.G. Pavão   +6 more
doaj   +1 more source

In Silico Structural Analysis of Human β‐Glucuronidase for Antibody–Drug Conjugates Optimization

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Giorgia Canini, Simona Saporiti, Crescenzo Coppa, Mara Rossi, Fabio Centola, Alessandro Arcovito   +5 more
wiley   +1 more source

Engineering of Substrate-Binding Domain to Improve Catalytic Activity of Chondroitin B Lyase with Semi-Rational Design

Current Issues in Molecular Biology
Dermatan sulfate and chondroitin sulfate are dietary supplements that can be utilized as prophylactics against thrombus formation. Low-molecular-weight dermatan sulfate (LMWDS) is particularly advantageous due to its high absorbability.
Miao Tian, Yuan-Yuan Xu, Yang-Nan Li, Shen Yu, Yi-Lin Wang, Xiao-Lai Ma, Ye-Wang Zhang   +6 more
doaj   +1 more source

Lipoprotein lipase enhances the interaction of low density lipoproteins with artery-derived extracellular matrix proteoglycans

Journal of Lipid Research, 1993
The association of plasma low density lipoproteins (LDL) with arterial proteoglycans (PG) is of key importance in LDL retention and modification in the artery wall.
IJ Edwards, IJ Goldberg, JS Parks, H Xu, WD Wagner   +4 more
doaj   +1 more source

Differential Expression of Specific Dermatan Sulfate Domains in Renal Pathology. [PDF]

PLoS ONE, 2015
Dermatan sulfate (DS), also known as chondroitin sulfate (CS)-B, is a member of the linear polysaccharides called glycosaminoglycans (GAGs). The expression of CS/DS and DS proteoglycans is increased in several fibrotic renal diseases, including ...
Joost F M Lensen, Johan van der Vlag, Elly M M Versteeg, Jack F M Wetzels, Lambert P W J van den Heuvel, Jo H M Berden, Toin H van Kuppevelt, Angelique L W M M Rops   +7 more
doaj   +1 more source