Results 81 to 90 of about 16,428 (265)

Engineering of Substrate-Binding Domain to Improve Catalytic Activity of Chondroitin B Lyase with Semi-Rational Design

open access: yesCurrent Issues in Molecular Biology
Dermatan sulfate and chondroitin sulfate are dietary supplements that can be utilized as prophylactics against thrombus formation. Low-molecular-weight dermatan sulfate (LMWDS) is particularly advantageous due to its high absorbability.
Miao Tian   +6 more
doaj   +1 more source

Dermatan sulfate reduces monocyte chemoattractant protein 1 and TGF-β production, as well as macrophage recruitment and myofibroblast accumulation in mice with unilateral ureteral obstruction

open access: yesBrazilian Journal of Medical and Biological Research, 2011
Selectins play an essential role in most inflammatory reactions, mediating the initial leukocyte-rolling event on activated endothelium. Heparin and dermatan sulfate (DS) bind and block P- and L-selectin function in vitro.
C.L.R. Belmiro   +6 more
doaj   +1 more source

Structure of glassy lithium sulfate films sputtered in nitrogen (LISON): Insight from Raman spectroscopy and ab initio calculations [PDF]

open access: yes, 2007
Raman spectra of thin solid electrolyte films obtained by sputtering a lithium sulfate target in nitrogen plasma are measured and compared to ab initio electronic structure calculations for clusters composed of 28 atoms. Agreement between measured and calculated spectra is obtained when oxygen atoms are replaced by nitrogen atoms and when the nitrogen ...
arxiv   +1 more source

Sulfated Glycosaminoglycans as Inhibitors for Chlamydia Infections: Molecular Weight and Sulfation Dependence

open access: yesMacromolecular Bioscience, Volume 25, Issue 4, April 2025.
Interactions between sulfated glycosaminoglycans (GAGs) and the adhesin OmcB of Chlamydia species are explored using a surface‐based binding assay and cell assays. Increased sulfation and molecular weight enhance GAG binding and reduce bacterial attachment, with heparin exhibiting superior inhibitory effects.
Sebastian Wintgens   +7 more
wiley   +1 more source

Selectivity in glycosaminoglycan binding dictates the distribution and diffusion of fibroblast growth factors in the pericellular matrix [PDF]

open access: yes, 2016
The range of biological outcomes generated by many signalling proteins in development and homeostasis is increased by their interactions with glycosaminoglycans, particularly heparan sulfate (HS).
Fernig, David G   +5 more
core   +1 more source

Synergistic Effects of a Mixture of Glycosaminoglycans to Inhibit Adipogenesis and Enhance Chondrocyte Features in Multipotent Cells

open access: yesCellular Physiology and Biochemistry, 2015
Background/Aims: Multipotent mesenchymal stem cells affect homeostasis of adipose and joint tissues. Factors influencing their differentiation fate are of interest for both obesity and joint problems.
Petar D. Petrov   +5 more
doaj   +1 more source

Exploring PtSO$_4$ and PdSO$_4$ phases: an evolutionary algorithm based investigation [PDF]

open access: yesPhys. Chem. Chem. Phys. 17, 18146 (2015), 2015
Metal sulfate formation is one of the major challenges to the emissions aftertreatment catalysts. Unlike the incredibly sulfation prone nature of Pd to form PdSO$_4$, no experimental evidence exits for the PtSO$_4$ formation. Given the mystery of nonexistence of the PtSO$_4$, we explore the PtSO$_4$ using a combined approach of evolutionary algorithm ...
arxiv   +1 more source

Proteoglycans and Hyaluronan in Normal and Aberrant Lung Development

open access: yesProteoglycan Research, Volume 3, Issue 2, April 2025.
ABSTRACT Lung development is a tightly regulated process that progresses through five distinct stages: embryonic, pseudoglandular, canalicular, saccular, and alveolar. Each stage is characterized by coordinated cellular interactions and structural changes driven by signals from epithelial, endothelial, and mesenchymal cells.
Andrea Reszegi   +4 more
wiley   +1 more source

Development of a fluorometric microtiter plate-based enzyme assay for arylsulfatase B (MPS VI) using dried blood spots

open access: yesMolecular Genetics and Metabolism Reports, 2014
Mucopolysaccharidosis type VI or Maroteaux–Lamy syndrome is an autosomal recessive lysosomal storage disorder caused by deficiency of arylsulfatase B (ARS-B) enzyme activity.
Anirudh J. Ullal   +2 more
doaj   +1 more source

Quantification of sulfated polysaccharides in urine by the Heparin Red mix-and-read fluorescence assay [PDF]

open access: yesarXiv, 2018
Quantification of sulfated polysaccharides in urine samples is relevant to pharmacokinetic studies in drug development projects and to the non-invasive diagnosis and therapy monitoring of mucopolysaccharidoses. The Heparin Red Kit is a particularly simple and user friendly fluorescence assay for the quantification of sulfated polysaccharides and has ...
arxiv  

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