Results 11 to 20 of about 9,563 (231)

Acyl–Acyl Carrier Protein Desaturases and Plant Biotic Interactions

Cells, 2021
Interactions between land plants and other organisms such as pathogens, pollinators, or symbionts usually involve a variety of specialized effectors participating in complex cross-talks between organisms.
Sami Kazaz, Romane Miray, Sébastien Baud   +2 more
doaj   +2 more sources

A metabolomic strategy defines the regulation of lipid content and global metabolism by Δ9 desaturases in Caenorhabditis elegans [PDF]

BMC Genomics, 2012
Background Caenorhabditis elegans provides a genetically tractable model organism to investigate the network of genes involved in fat metabolism and how regulation is perturbed to produce the complex phenotype of obesity. C.
Castro Cecilia, Sar Funda, Shaw W Robert, Mishima Masanori, Miska Eric A, Griffin Julian L   +5 more
doaj   +5 more sources

Diversification of substrate specificities in teleostei Fads2: characterization of Δ4 and Δ6Δ5 desaturases of Chirostoma estor[S] [PDF]

Journal of Lipid Research, 2014
Currently existing data show that the capability for long-chain PUFA (LC-PUFA) biosynthesis in teleost fish is more diverse than in other vertebrates.
Jorge Fonseca-Madrigal, Juan C. Navarro, Francisco Hontoria, Douglas R. Tocher, Carlos A. Martínez-Palacios, Óscar Monroig   +5 more
doaj   +2 more sources

Genetic variation in lipid desaturases and its impact on the development of human disease [PDF]

Lipids in Health and Disease, 2010
Perturbations in lipid metabolism characterize many of the chronic diseases currently plaguing our society, such as obesity, diabetes, and cardiovascular disease.
Mutch David M, Ma David WL, Merino Diana M   +2 more
doaj   +2 more sources

Simultaneous overexpression of ∆6-, ∆12- and ∆9-desaturases enhanced the production of γ-linolenic acid in Mucor circinelloides WJ11

Frontiers in Microbiology, 2022
Mucor circinelloides WJ11, an oleaginous filamentous fungus, produces 36% lipid of its cell dry weight when cultured in a high C/N ratio medium, however, the yield of γ-linolenic acid (GLA) is insufficient to make it competitive with other plant sources.
Xiuwen Wang, Junhuan Yang, Hassan Mohamed, Hassan Mohamed, Aabid Manzoor Shah, Shaoqi Li, Shuxian Pang, Chen Wu, Futing Xue, Wenyue Shi, Beenish Sadaqat, Yuanda Song   +11 more
doaj   +1 more source

Lipidomic analysis of cancer cells cultivated at acidic pH reveals phospholipid fatty acids remodelling associated with transcriptional reprogramming

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cancer cells need to modulate the biosynthesis of membrane lipids and fatty acids to adapt themselves to an accelerated rate of cell division and survive into an extracellular environment characterised by a low pH.
Lorena Urbanelli, Sandra Buratta, Mariantonia Logozzi, Nico Mitro, Krizia Sagini, Rossella Di Raimo, Donatella Caruso, Stefano Fais, Carla Emiliani   +8 more
doaj   +1 more source

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Double defense: enhancing tobacco with cyanobacterial and thaumatin genes [PDF]

Frontiers in Bioengineering and Biotechnology
Tetiana Kyrpa, Yelizaveta Prokhorova, Maksym Kharkhota, Mykola Kuchuk   +3 more
doaj   +2 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source