Results 41 to 50 of about 9,563 (231)

Drosophila lacks C20 and C22 PUFAs

Journal of Lipid Research, 2010
Drosophila melanogaster has been considered a model organism for investigating human diseases and genetic pathways. Whether Drosophila is an ideal model for nutrigenomics, especially for FA metabolism, however, remains to be illustrated.
Li Rong Shen, Chao Qiang Lai, Xiang Feng, Laurence D. Parnell, Jian Bo Wan, Jing D. Wang, Duo Li, Jose M. Ordovas, Jing X. Kang   +8 more
doaj   +1 more source

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, EarlyView.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source

Identification and Functional Characterization of Genes Encoding Omega-3 Polyunsaturated Fatty Acid Biosynthetic Activities from Unicellular Microalgae

Marine Drugs, 2013
In order to identify novel genes encoding enzymes involved in the biosynthesis of nutritionally important omega-3 long chain polyunsaturated fatty acids, a database search was carried out in the genomes of the unicellular photoautotrophic green alga ...
Royah Vaezi, Johnathan A. Napier, Olga Sayanova   +2 more
doaj   +1 more source

Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2017/0067070 A1) [PDF]

, 2017
The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid ...
Sayanova, O. V., Napier, J. A., Bauer, J.   +2 more
core  

The role of FADS gene polymorphic variants in adaptation to the Northern climatic conditions and metabolic disorders

Якутский медицинский журнал
The review summarizes the studies of the role of the FADS gene in the metabolism of polyunsaturated fatty acids, as one of the mechanisms of human adaptation to the environmental conditions, in particular, a cold climate.
T. M. Sivtseva, T. M. Klimova, R. N. Zakharova, E. P. Ammosova, V. L. Osakovsky   +4 more
doaj   +1 more source

Novel Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 2012/0124705 A1) [PDF]

, 2012
The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid ...
Sayanova, O. V., Napier, J. A., Bauer , J.   +2 more
core  

Revisiting Securidaca longipedunculata Seed Oil: Applying NMR and Mass Spectroscopy to Confirm the Presence of 2‐Acetyl‐1,3‐Diacyl–sn‐Glycerols and Conjugated Hydroxydienoic Fatty Acids

Journal of the American Oil Chemists' Society, EarlyView.
The manuscript confirms and expands on previous reports concerning the presence of unusual conjugated hydroxydienoic fatty acids and acetyl‐TAG in the seed oil of Securidaca longipedunculata. The location of acetate only at sn‐2 of TAG was conclusively shown by high resolution NMR and hydroxy seed fatty acids are characterized.
Mark A. Smith, Jianfeng Zhu, Jin‐Yue Sun   +2 more
wiley   +1 more source

Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia [PDF]

, 2019
Insect pheromones are often derived from fatty acid metabolism. Fatty acid desaturases, enzymes introducing double bonds into fatty acids, are crucial for the biosynthesis of these chemical signals.
Bruckmann, Astrid, Reinhard Sterner, Monroig, Oscar, Rainer Merkl, Merkl, Rainer, Malcicka, Miriama, Straub, Kristina, Kabeya, Naoki, Sterner, Reinhard, Ruther, Joachim, Miriama Malcicka, Semmelmann, Florian, Joachim Ruther, Broschwitz, Bastian, Astrid Bruckmann, Bastian Broschwitz, Kristina Straub, Jacintha Ellers, Ellers, Jacintha, Naoki Kabeya, Oscar Monroig, Florian Semmelmann   +21 more
core   +4 more sources

Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα

Journal of Lipid Research, 2002
In the process of seeking sterol regulatory element-binding protein 1a (SREBP-1a) target genes, we identified and cloned a cDNA clone encoding mouse Δ5-desaturase (D5D). The hepatic expression of D5D as well as Δ6-desaturase (D6D) was highly activated in
Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi, Michiyo Amemiya-Kudo, Tomohiro Yoshikawa, Alyssa H. Hasty, Yoshiaki Tamura, Jun-ichi Osuga, Hiroaki Okazaki, Yoko Iizuka, Akimitsu Takahashi, Hirohito Sone, Takanari Gotoda, Shun Ishibashi, Nobuhiro Yamada   +14 more
doaj   +1 more source

Different Cis-Regulatory Elements Control the Tissue-Specific Contribution of Plastid ω-3 Desaturases to Wounding and Hormone Responses

Frontiers in Plant Science, 2021
Trienoic fatty acids are essential constituents of biomembranes and precursors of jasmonates involved in plant defense responses. Two ω-3 desaturases, AtFAD7 and AtFAD8, synthetize trienoic fatty acids in the plastid.
María A. Luján, Ángel Soria-García, Ana Claver, Patricia Lorente, María C. Rubio, Rafael Picorel, Miguel Alfonso   +6 more
doaj   +1 more source