Results 31 to 40 of about 9,563 (231)

Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme

Biomolecules, 2020
The expression of desaturases is higher in many types of cancer, and despite their recognized role in oncogenesis, there has been no research on the expression of desaturases in glioblastoma multiforme (GBM).
Jan Korbecki, Klaudyna Kojder, Dariusz Jeżewski, Donata Simińska, Maciej Tarnowski, Patrycja Kopytko, Krzysztof Safranow, Izabela Gutowska, Marta Goschorska, Agnieszka Kolasa-Wołosiuk, Barbara Wiszniewska, Dariusz Chlubek, Irena Baranowska-Bosiacka   +12 more
doaj   +1 more source

Bioinformatic approach for the identification of plant species that accumulate palmitoleic acid

Electronic Journal of Biotechnology, 2022
Background: Palmitoleic acid is a fatty acid that possesses nutritional, health, and industrial applications. However, it accumulates in the seed oil of few plant species that often lack agronomic value.
Gabriel Salazar Robles, Luis Ricardo Hernández, Yagul Pedraza Pérez, Zaida Nelly Juárez, Maricela Rodríguez Acosta, Beatriz Pérez Armendáriz, Elizabeth Bautista Rodríguez, Elie Girgis El Kassis   +7 more
doaj   +1 more source

Pathways of Lipid Metabolism in Marine Algae, Co-Expression Network, Bottlenecks and Candidate Genes for Enhanced Production of EPA and DHA in Species of Chromista

Marine Drugs, 2013
The importance of n-3 long chain polyunsaturated fatty acids (LC-PUFAs) for human health has received more focus the last decades, and the global consumption of n-3 LC-PUFA has increased.
Alice Mühlroth, Keshuai Li, Gunvor Røkke, Per Winge, Yngvar Olsen, Martin F. Hohmann-Marriott, Olav Vadstein, Atle M. Bones   +7 more
doaj   +1 more source

Identification and functional analysis of delta-9 desaturase, a key enzyme in PUFA Synthesis, isolated from the oleaginous diatom Fistulifera. [PDF]

PLoS ONE, 2013
Oleaginous microalgae are one of the promising resource of nonedible biodiesel fuel (BDF) feed stock alternatives. Now a challenge task is the decrease of the long-chain polyunsaturated fatty acids (PUFAs) content affecting on the BDF oxidative stability
Masaki Muto, Chihiro Kubota, Masayoshi Tanaka, Akira Satoh, Mitsufumi Matsumoto, Tomoko Yoshino, Tsuyoshi Tanaka   +6 more
doaj   +1 more source

The role of cytochrome b 5 fusion desaturases in the synthesis of polyunsaturated fatty acids

, 2003
The biosynthetic pathway of polyunsaturated fatty acids (PUFAs) has been the subject of much interest over the last few years. Significant progress has been made in the identification of the enzymes required for PUFA synthesis; in particular, the fatty ...
Sayanova, O. V., Michaelson, L. V., Napier, J. A.   +2 more
core   +1 more source

AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin

Journal of Lipid Research, 2019
The FA composition of phospholipids must be tightly regulated to maintain optimal cell membrane properties and compensate for a highly variable supply of dietary FAs.
Mario Ruiz, Marcus Ståhlman, Jan Borén, Marc Pilon   +3 more
doaj   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Polyunsaturated fatty acid elongation and desaturation in activated human T-cells: ELOVL5 is the key elongase

Journal of Lipid Research, 2018
PUFAs are important constituents of membrane glycerophospholipids. However, changes in the capacities to incorporate and metabolize PUFAs when cells enter the cell cycle have not been thoroughly studied.
Philippe-Pierre Robichaud, Jean Eric Munganyiki, Eric Boilard, Marc E. Surette   +3 more
doaj   +1 more source

Fatty Acid Desaturases And Elongases And Uses Thereof (Patent US 9493520 B2 ) [PDF]

, 2016
The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid ...
Sayanova, O. V., Napier, J. A., Bauer, J.   +2 more
core  

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source