Results 21 to 30 of about 9,563 (231)
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
AMB Express, 2018 Fatty acid desaturases play a key role in producing polyunsaturated fatty acids by converting single bonds to double bonds. In the present study, a total of 13, 12, 8 and 8 candidate fatty acid desaturases genes were identified in the Aspergillus oryzae,
Wen Tang +9 more
doaj +1 more source
Open Biology, 2021 The long-standing paradigm establishing that global production of Omega-3 (n–3) long-chain polyunsaturated fatty acids (LC-PUFA) derived almost exclusively from marine single-cell organisms, was recently challenged by the discovery that multiple ...
Naoki Kabeya +6 more
doaj +1 more source
Frontiers in Genetics, 2012 Genetic variation in fatty acid desaturases (FADS) has previously been linked to long-chain polyunsaturated fatty acids (PUFAs) in adipose tissue and cardiovascular risk.
Stella eAslibekyan +9 more
doaj +1 more source
The desaturase gene family : an evolutionary study of putative speciation genes in 12 species of Drosophila [PDF]
, 2012 The formation and persistence of species are the subject of much debate among biologists. Many species of Drosophila are behaviourally isolated, meaning that heterospecific individuals are not attracted to one another and do not interbreed.
Keays, Maria C.
core +2 more sources
Current Issues in Molecular Biology, 2022 Fatty acid desaturases play an important role in maintaining the appropriate structure and function of biological membranes. The biochemical characterization of integral membrane desaturases, particularly ω3 and ω6 desaturases, has been limited by ...
Mingxuan Wang +3 more
doaj +1 more source
Delta-8 desaturation activity varies among fatty acyl desaturases of teleost fish: high activity in delta-6 desaturases of marine species [PDF]
, 2011 The benefits of dietary fish and fish oil are derived from n-3 long-chain polyunsaturated fatty acids (LC-PUFA) that have beneficial effects in a range of human diseases and pathologies such as cardiovascular and other inflammatory disorders, neural ...
Monroig, Oscar +2 more
core +1 more source
Desaturases : structural and mechanistic insights into the biosynthesis of unsaturated fatty acids [PDF]
, 2022 This review highlights the key role of fatty acid desaturases in the synthesis of naturally occurring, more common and not, unsaturated fatty acids. The three major classes of fatty acid desaturases, such as acyl-lipid, acyl-acyl carrier protein and acyl-
Cerone, M. +5 more
core +1 more source
Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae
Angewandte Chemie, EarlyView.The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray +4 more
wiley +2 more sources
Genetic regulation of unsaturated fatty acid composition in C. elegans.
PLoS Genetics, 2006 Delta-9 desaturases, also known as stearoyl-CoA desaturases, are lipogenic enzymes responsible for the generation of vital components of membranes and energy storage molecules.
Trisha J Brock +2 more
doaj +1 more source