Results 1 to 10 of about 16,875 (201)

Maintenance of Energy Metabolism Is an Integral Part of Plakophilin-2 and Desmosome Functions [PDF]

JACC: Basic to Translational Science
Summary: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death.
J. Alex Aycinena, MS, Anley E. Tefera, PhD, Isaac Perea-Gil, PhD, Duncan Holbrook-Smith, PhD, Kevin Williams, PhD, Reva Shenwai, MS, Farshad Farshidfar, PhD, Brendan Ryback, PhD, Katelyn Foppe, MS, Iris Wu, BS, Aliya Zeng, BS, Melissa Van Pell, BS, Emma Xu, PhD, Joseph Woods, BS, Samantha Jones, MBA, Yolanda Hatter, BS, Cristina Dee-Hoskins, BS, Jessie Madariaga, BS, Kevin Robinson, BS, Amara Greer-Short, PhD, Xiaomei Song, PhD, Kathryn N. Ivey, PhD, James Priest, MD, Gretchen Argast, PhD, Timothy Hoey, PhD, Edward Driggers, PhD, Zhihong Jane Yang, PhD   +26 more
doaj   +2 more sources

Hirudin suppresses hematogenous metastasis by targeting desmosome junction transition in circulating tumor cell clusters via HIF-1α–DSG2 signaling [PDF]

Experimental and Molecular Medicine
s Circulating tumor cell (CTC) clusters, key in metastasis, rely on intercellular junctions for stability. However, the specific mechanisms governing intercellular connections within CTC clusters and the strategy targeting intercellular junctions to ...
Jueyao Zou, Junfeng Shi, Qiong Chen, Ziyan Zhu, Tongyao Hu, Zhengyu Zhang, Zhiqiang Pan, Fei Xu, Yong Zhu, Yuanyuan Wu, Yang Zhao, Aiyun Wang, Yin Lu, Yanhong Pan, Wenxing Chen   +14 more
doaj   +2 more sources

The impact of signaling pathways on the desmosome ultrastructure in pemphigus [PDF]

Frontiers in Immunology
IntroductionThe autoantibody-driven disease pemphigus vulgaris (PV) impairs desmosome adhesion in the epidermis. In desmosomes, the pemphigus autoantigens desmoglein 1 (Dsg1) and Dsg3 link adjacent cells.
Thomas Schmitt, Julia Huber, Julia Pircher, Enno Schmidt, Enno Schmidt, Jens Waschke   +5 more
doaj   +2 more sources

Epicardial Abnormalities and Mesenchymal/Hematopoietic Cell Expansion in Plakophilin 2-Null Mouse Embryonic Hearts [PDF]

Cells
Desmosomal junctions provide structural stability supporting concerted cardiomyocyte contractility. Previously, we demonstrated that a deficiency in the desmosomal transmembrane cadherin desmoglein 2 (Dsg2) reduces desmosome formation and disrupts ...
Mistura Dolapo Bolaji, Pia E. Hartmann, Eva Miriam Buhl, Robin M. W. Colpaert, Francesca Gasparella, Leon J. de Windt, Martina Calore, Rudolf E. Leube, Hoda Moazzen   +8 more
doaj   +2 more sources

The desmosomal cadherin Desmoglein-2 controls extracellular matrix expression and remodeling via NF-κB signaling in keratinocytes [PDF]

Frontiers in Cell and Developmental Biology
Desmogleins are transmembrane cadherin proteins and obligate members of the desmosome, a cell-cell adhesion complex which connects adjacent cells and provides structural integrity to tissues.
Sadie E. Hunter, Zara T. Patel, Beatriz Mateo, Joshua M. Powers, Austin Y. Shull, Adi D. Dubash   +5 more
doaj   +2 more sources

Epidermal stem cells control periderm injury repair via matrix-driven specialization of intercellular junctions [PDF]

Nature Communications
Epidermal stem cells interact with the extracellular matrix (ECM) to regulate their differentiation and maintain skin architecture. Here, we demonstrate a role for basal epidermal stem cells (BECs)-ECM interaction in regulating adhesion molecules ...
Helen Mengze He, Liana C. Boraas, Jon M. Bell, Xiangyu Gong, Sophia L. Iannaccone, Zhang Wen, Michael Mak, Marina Carlson, Kaelyn Sumigray, Stefania Nicoli   +9 more
doaj   +2 more sources

Mechanisms Causing Acantholysis in Pemphigus-Lessons from Human Skin

Frontiers in Immunology, 2022
Pemphigus vulgaris (PV) is an autoimmune bullous skin disease caused primarily by autoantibodies (PV-IgG) against the desmosomal adhesion proteins desmoglein (Dsg)1 and Dsg3.
Desalegn Tadesse Egu, Thomas Schmitt, Jens Waschke   +2 more
doaj   +1 more source

Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. [PDF]

, 2013
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of ...
Hartlieb, Eva, Kempf, Bettina, Partilla, Miriam, Spindler, Volker, Vigh, Balázs, Waschke, Jens   +5 more
core   +12 more sources

Desmosome assembly and disassembly are membrane raft-dependent. [PDF]

PLoS ONE, 2014
Strong intercellular adhesion is critical for tissues that experience mechanical stress, such as the skin and heart. Desmosomes provide adhesive strength to tissues by anchoring desmosomal cadherins of neighboring cells to the intermediate filament ...
Sara N Stahley, Masataka Saito, Victor Faundez, Michael Koval, Alexa L Mattheyses, Andrew P Kowalczyk   +5 more
doaj   +1 more source

Desmosomes as Signaling Hubs in the Regulation of Cell Behavior

Frontiers in Cell and Developmental Biology, 2021
Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic and stress conditions. These functions rely on their unique structural properties, which enable them to respond to context-dependent signals and transmit them to ...
Lisa Müller, Mechthild Hatzfeld, René Keil   +2 more
doaj   +1 more source