Results 11 to 20 of about 16,875 (201)

The Desmosome [PDF]

Cold Spring Harbor Perspectives in Biology, 2009
Desmosomes are intercellular junctions that tether intermediate filaments to the plasma membrane. Desmogleins and desmocollins, members of the cadherin superfamily, mediate adhesion at desmosomes. Cytoplasmic components of the desmosome associate with the desmosomal cadherin tails through a series of protein interactions, which serve to recruit ...
Emmanuella, Delva, Dana K, Tucker, Andrew P, Kowalczyk   +2 more
openaire   +2 more sources

Pervanadate stabilizes desmosomes [PDF]

Cell Adhesion & Migration, 2008
Desmosomes are intercellular junctions responsible for strong cell-cell adhesion in epithelia and cardiac muscle. Numerous studies have shown that the other major type of epithelial cell adhesion, the adherens junction, is destabilized by src-induced tyrosine phosphorylation of two of its principal components, E-cadherin and beta-catenin.
Garrod, D., Fisher, C., Smith, A., Nie, Z.   +3 more
openaire   +3 more sources

The desmosome and pemphigus [PDF]

Histochemistry and Cell Biology, 2008
Desmosomes are patch-like intercellular adhering junctions ("maculae adherentes"), which, in concert with the related adherens junctions, provide the mechanical strength to intercellular adhesion. Therefore, it is not surprising that desmosomes are abundant in tissues subjected to significant mechanical stress such as stratified epithelia and ...
Jens Waschke, H Aberle, AR Ahmed, K Akat, N Akhtar, A Al-Amoudi, S Alema, M Amagai, M Amagai, M Amagai, M Amagai, M Amagai, M Amagai, M Amagai, M Amagai, M Amagai, M Amagai, M Amagai, M Amagai, M Amagai, PZ Anastasiadis, BD Angst, GJ Anhalt, GJ Anhalt, V Aoki, Y Aoyama, Y Aoyama, DK Armstrong, J Arnemann, J Arnemann, J Arredondo, A Asimaki, A Baroni, W Baumgartner, W Baumgartner, C Baykal, LA Bazley, H Bazzi, JJ Bech-Serra, SA Benitah, R Benndorf, P Berkowitz, P Berkowitz, P Berkowitz, P Berkowitz, EH Beutner, K Bhol, C Bierkamp, C Bierkamp, OW Blaschuk, TJ Boggon, S Bonne, S Bonne, EA Bornslaeger, EA Bornslaeger, CM Borrmann, VM Braga, VM Braga, D Brennan, ID Burdett, XR Bustelo, RS Buxton, JC Bystryn, JC Bystryn, JC Bystryn, R Caldelari, CC Calkins, CC Calkins, X Chen, AI Chernyavsky, AI Chernyavsky, AI Chernyavsky, AI Chernyavsky, M Chidgey, NA Chitaev, NA Chitaev, HJ Choi, A Chrostek, N Cirillo, N Cirillo, N Cirillo, N Cirillo, N Cirillo, N Cirillo, JE Collins, P Cowin, P Cowin, CM Cowley, A Bruin de, Z Den, J Dhitavat, J Dhitavat, LA Diaz, X Ding, P Drochmans, RL Dusek, RL Dusek, PM Elias, P Elias, C Esaki, L Eshkind, RW Eyre, RW Eyre, RM Farb, MG Farquhar, AM Farrell, DW Fawcett, DW Fawcett, C Feliciani, C Feliciani, WW Franke, WW Franke, WW Franke, M Frusic-Zlotkin, M Frusic-Zlotkin, M Fukata, Y Futei, GI Gallicano, GI Gallicano, E Garcia-Gras, DR Garrod, CA Gaudry, B Gerull, S Getsios, S Getsios, D Geum, GJ Giudice, R Gniadecki, LM Godsel, G Gorbsky, SA Grando, SA Grando, KJ Green, KJ Green, KS Grossmann, J Guay, W Gusek, DE Gutstein, MK Hacker-Foegen, B Hammerling, Y Hanakawa, Y Hanakawa, MJ Hardman, KE Harman, K Hashimoto, T Hashimoto, S Hatsell, M Hatzfeld, M Hatzfeld, M Hatzfeld, W He, HW Heid, H Hennings, M Hertl, W Heupel, A Heuser, B Holthofer, P Hu, F Iraji, K Ishii, K Ishii, G Izumi, AB Jaffe, MJ Jamora, JJ Jefferson, Y Jinbu, JC Jones, JC Jones, MF Jonkman, T Kamei, S Karpati, Y Kawasaki, DE Kelly, TE Kimura, IA King, Y Kitajima, Y Kitajima, Y Kitajima, Y Kitajima, A Kljuic, PJ Koch, PJ Koch, PJ Koch, PJ Koch, S Kodama, J Koeser, FT Kolligs, C Kolly, NJ Korman, MD Kottke, L Koulu, AP Kowalczyk, AP Kowalczyk, AP Kowalczyk, AP Kowalczyk, AP Kowalczyk, A Lanza, WF Lever, L Lo Muzio, JH Lorch, A Lyell, O Maeda, MG Mahoney, MG Mahoney, C Marcozzi, M Mathur, JA McGrath, JA McGrath, G McKoy, JR McMillan, NS McNutt, ME Melish, O Memar, GK Menon, AJ Merritt, C Mertens, C Mertens, C Mertens, M Milingou, KC Miranda, S Miravet, S Miyagawa, R Moll, R Moll, S Morioka, H Mueller, E Muller, R Muller, EJ Muller, R Muller, T Nagasaka, MR Namazi, VT Nguyen, VT Nguyen, VT Nguyen, VT Nguyen, VT Nguyen, F Nollet, EE Norgett, AJ North, GF Odland, K Osada, M Overduin, OO Panasenko, M Pasdar, M Pasdar, M Pasdar, AS Payne, AS Payne, B Pelacho, MD Perng, O Pertz, S Pieperhoff, K Pilichou, M Puviani, A Rampazzo, L Rickman, B Rock, B Rock, J Rodriguez, K Rosen, P Ruiz, R Ruiz-Velasco, SK Runswick, A Sakuntabhai, VK Salato, I Sanchez-Carpintero, B Santiago-Josefat, M Sato, BM Schaefer, S Schafer, JR Schiltz, M Schmelz, M Schmelz, M Schmelz, M Schmelz, A Schmidt, A Schmidt, E Schmidt, T Schuh, MA Schwarz, M Seishima, M Seishima, M Seishima, M Sekiguchi, L Shapiro, P Sharma, HM Sheu, T Shimada, I Shimanovich, H Shimizu, A Shimizu, A Shimizu, Y Shirakata, E Shu, C Sitaru, CJ Skerrow, EA Smith, T Sobolik-Delmaire, A Sonnenberg, S Spaeth, V Spindler, JR Stanley, JR Stanley, TS Stappenbeck, DC Swartzendruber, SE Syed, P Syrris, Y Takahashi, SM Troyanovsky, SM Troyanovsky, SM Troyanovsky, RB Troyanovsky, C Tselepis, K Tsunoda, MC Udey, JP Tintelen van, V Vasioukhin, V Vasioukhin, CM Veldman, JK Wahl III, JK Wahl, H Wan, X Wang, X Wang, J Waschke, J Waschke, J Waschke, J Weiske, MW Wendeler, NV Whittock, NV Whittock, NV Whittock, GF Wilgram, GF Wilgram, L Williamson, L Williamson, R Windoffer, S Woll, H Wu, Y Yamamoto, Y Yamamoto, KB Yancey, SW Yeh, T Yin, T Yin, K Yoshida, I Zagorodniuk   +347 more
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Overview of junctional complexes during mammalian early embryonic development

Frontiers in Endocrinology, 2023
Cell-cell junctions form strong intercellular connections and mediate communication between blastomeres during preimplantation embryonic development and thus are crucial for cell integrity, polarity, cell fate specification and morphogenesis.
Ceren Canse, Ecem Yildirim, Aylin Yaba
doaj   +1 more source

EGFR inhibition leads to enhanced desmosome assembly and cardiomyocyte cohesion via ROCK activation

JCI Insight, 2023
Arrhythmogenic cardiomyopathy (AC) is a familial heart disease partly caused by impaired desmosome turnover. Thus, stabilization of desmosome integrity may provide new treatment options.
Maria Shoykhet, Orsela Dervishi, Philipp Menauer, Matthias Hiermaier, Sina Moztarzadeh, Colin Osterloh, Ralf J. Ludwig, Tatjana Williams, Brenda Gerull, Stefan Kääb, Sebastian Clauss, Dominik Schüttler, Jens Waschke, Sunil Yeruva   +13 more
doaj   +1 more source

Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover. [PDF]

, 2016
Desmosomes are prominent adhesive junctions present between many epithelial cells as well as cardiomyocytes. The mechanisms controlling desmosome assembly and remodeling in epithelial and cardiac tissue are poorly understood.
Johnson, Keith R., Kowalczyk, Andrew P., Lewis, Joshua D., Mahoney, My G., Overmiller, Andrew M., Roberts, Brett J., Svoboda, Robert A., Wahl, James K.   +7 more
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Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes [PDF]

, 2016
Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
Ali, Jawahir, Banning, Antje, Eming, Rüdiger, Exner, Yvonne, Hertl, Michael, Kurrle, Nina, Tikkanen, Ritva, Völlner, Frauke   +7 more
core   +1 more source

E-cadherin binds to desmoglein to facilitate desmosome assembly

eLife, 2018
Desmosomes are adhesive junctions composed of two desmosomal cadherins: desmocollin (Dsc) and desmoglein (Dsg). Previous studies demonstrate that E-cadherin (Ecad), an adhesive protein that interacts in both trans (between opposing cells) and cis (on the
Omer Shafraz, Matthias Rübsam, Sara N Stahley, Amber L Caldara, Andrew P Kowalczyk, Carien M Niessen, Sanjeevi Sivasankar   +6 more
doaj   +1 more source

Tissue engineering a fetal membrane [PDF]

, 2011
The aim of this study was to construct an artificial fetal membrane (FM) by combination of human amniotic epithelial stem cells (hAESCs) and a mechanically enhanced collagen scaffold containing encapsulated human amniotic stromal fibroblasts (hASFs ...
Adam M. Squires, Anna L. David, Bipasha Chowdhury, Che John Connon, Connon C.J., Grinnell F., Ian William Hamley, Jones R.R., Kirkham S.M., Roanne Razalia Jones, Shengli Mi, Trinkaus R.V.   +11 more
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Dsg2 Upregulation as a Rescue Mechanism in Pemphigus

Frontiers in Immunology, 2020
In pemphigus vulgaris (PV), autoantibodies directed against the desmosomal cadherin desmoglein (Dsg) 3 cause loss of intercellular adhesion. It is known that Dsg3 interactions are directly inhibited by autoantibody binding and that Dsg2 is upregulated in
Anna M. Sigmund, Letyfee S. Steinert, Desalegn T. Egu, Franziska C. Bayerbach, Jens Waschke, Franziska Vielmuth   +5 more
doaj   +1 more source