Results 21 to 30 of about 16,875 (201)
Role of Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma
Biomolecules, 2022 Cell–cell junctions comprise various structures, including adherens junctions, tight junctions, desmosomes, and gap junctions. They link cells to each other in tissues and regulate tissue homeostasis in critical cellular processes.
Qian-Rui Xu +8 more
doaj +1 more source
Characterization of cells of amniotic fluids by immunological identification of intermediate-sized filaments: Presence of cells of different tissue origin [PDF]
, 1981 Antibodies against intermediate-sized filaments, of the prekeratin or vimentin type, were used to investigate the presence of these filaments by indirect immunofluorescence microscopy in cultured and non-cultured amniotic fluid cells, in frozen sections ...
Cremer, Marion +4 more
core +1 more source
Hemidesmosome Mutations Contribute to the Onset and Severity of Acquired Autoimmune Bullous Diseases. [PDF]
MedComm (2020)This study examined hemidesmosome assembly‐related genes in pemphigoid diseases, revealing variants linked to disease onset and severity. Functional analyses, including Caenorhabditis elegans models, Ker‐CT transcriptomics, human proteomics, etc., demonstrated that ITGA6 mutations destabilize hemidesmosomes, disrupt dermal–epidermal adhesion, and ...
Cao S +19 more
europepmc +2 more sources
Cortical tension regulates desmosomal morphogenesis
Frontiers in Cell and Developmental Biology, 2022 Mechanical stability is a fundamental and essential property of epithelial cell sheets. It is in large part determined by cell-cell adhesion sites that are tightly integrated by the cortical cytoskeleton.
Marcin Moch +2 more
doaj +1 more source
Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis.
PLoS Genetics, 2010 Dysregulated cell-cell adhesion plays a critical role in epithelial cancer development. Studies of human and mouse cancers have indicated that loss of adhesion complexes known as adherens junctions contributes to tumor progression and metastasis.
Veronica G Beaudry +8 more
doaj +1 more source
Frontiers in Physiology, 2020 Intercalated discs (ICDs), which connect adjacent cardiomyocytes, are composed of desmosomes, adherens junctions (AJs) and gap junctions (GJs). Previous data demonstrated that adrenergic signaling enhances cardiac myocyte cohesion, referred to as ...
Sunil Yeruva +5 more
doaj +1 more source
Desmosomal connectomics of all somatic muscles in an annelid larva
eLife, 2022 Cells form networks in animal tissues through synaptic, chemical, and adhesive links. Invertebrate muscle cells often connect to other cells through desmosomes, adhesive junctions anchored by intermediate filaments.
Sanja Jasek +6 more
doaj +1 more source
Journal of the Formosan Medical Association, 2008 Background/Purpose: Desmosome gene mutations have been reported in patients with arrhythmogenic right ventricular dysplasia (ARVD). However, there are hardly any genetic studies in Asians.
Chih-Chieh Yu +7 more
doaj +1 more source
Desmosomal Antigens Are Not Recognized by the Majority of Pemphigus Autoimmune Sera [PDF]
, 1983 Sera from 7 patient with pemphigus vulgaris and both mouse and rabbit antisera against bovine epidermal desmosomes contained antibodies that bound to cell surface components of the spinous layer of bovine epidermis.
Gorbsky, Gary +2 more
core +2 more sources
Frontiers in Immunology, 2020 Pemphigus is a chronic autoimmune blistering disorder, characterized by (muco-)cutaneous erosions due to autoantibodies against desmoglein 3 and/or 1. Pemphigus induction might be associated with drugs, malignancy or radiation therapy (RT); the latter ...
Franziska Schauer +6 more
doaj +1 more source