Results 41 to 50 of about 4,569 (202)

Effect of diosmetin on proliferation, apoptosis and migration of colorectal cancer cells by regulating STX17-AS1/miR-383-5p axis

Di-san junyi daxue xuebao, 2021
Objective To investigate the effect of diosmetin on the proliferation, apoptosis and migration of colorectal cancer cells, and further to analyze whether its mechanism is related to the regulation of STX17-AS1/miR-383-5p axis.
WU Yuan, LIU Jiyu, ZHANG Qin
doaj   +1 more source

Synthetic flavonoids as novel modulators of platelet function and thrombosis [PDF]

, 2019
Cardiovascular diseases represent a major cause of mortality and morbidity in the world and thrombotic conditions such as heart attacks and strokes are caused by unwarranted activation of platelets and subsequent formation of blood clots (thrombi) within
Dina A. I. Albadawi, Divyashree Ravishankar, Helen M. I. Osborn, Page, Sakthivel Vaiyapuri, Samanta, Thomas M. Vallance, Vlahos   +7 more
core   +1 more source

Design of an Herbal Preparation Composed by a Combination of Ruscus aculeatus L. and Vitis vinifera L. Extracts, Magnolol and Diosmetin to Address Chronic Venous Diseases through an Anti-Inflammatory Effect and AP-1 Modulation

Plants, 2023
Chronic venous disease (CVD) is an often underestimated inflammatory pathological condition that can have a serious impact on quality of life. Many therapies have been proposed to deal with CVD, but unfortunately the symptoms recur with increasing ...
Raffaella Nocera, Daniela Eletto, Valentina Santoro, Valentina Parisi, Maria Laura Bellone, Marcello Izzo, Alessandra Tosco, Fabrizio Dal Piaz, Giuliana Donadio, Nunziatina De Tommasi   +9 more
doaj   +1 more source

On-line identification of minor flavones from sugarcane juice by LC/UV/MS and post-column derivatization [PDF]

, 2009
This work describes the on-line characterization of minor flavones from sugarcane (Saccharum officinarum) juice by high-performance liquid chromatography coupled to diode array UV detection and mass spectrometry (LC/UV/MS) using atmospheric pressure ...
COLOMBO, Renata, HOSTETTMANN, Kurt, NDJOKO, Karine, QUEIROZ, Emerson F., YARIWAKE, Janete H.   +4 more
core   +1 more source

Regioselective Glucuronidation of Diosmetin and Chrysoeriol by the Interplay of Glucuronidation and Transport in UGT1A9-Overexpressing HeLa Cells.

PLoS ONE, 2016
This study aimed to determine the reaction kinetics of the regioselective glucuronidation of diosmetin and chrysoeriol, two important methylated metabolites of luteolin, by human liver microsomes (HLMs) and uridine-5'-diphosphate glucuronosyltransferase (
Xuejun Zeng, Jian Shi, Min Zhao, Qingwei Chen, Liping Wang, Huangyu Jiang, Feifei Luo, Lijun Zhu, Linlin Lu, Xinchun Wang, Zhongqiu Liu   +10 more
doaj   +1 more source

Modulatory Effect of Diosmin and Diosmetin on Metalloproteinase Activity and Inflammatory Mediators in Human Skin Fibroblasts Treated with Lipopolysaccharide

Molecules, 2022
Diosmin is widely used as a venoactive drug in the pharmacological treatment of chronic venous disorders. It exerts a strong protective effect on blood vessels via an increase in the elasticity of vessel walls and reduces the permeability of capillary ...
Marcin Feldo, Magdalena Wójciak, Aleksandra Ziemlewska, Sławomir Dresler, Ireneusz Sowa   +4 more
doaj   +1 more source

HPLC microfractionation of flavones and antioxidant (radical scavenging) activity of Saccharum officinarum L. [PDF]

, 2008
The antioxidant activity of sugarcane (Saccharum officinarum L.) juice towards DPPH reagent was determined (EC50) and the main compounds with radical scavenging activity in juice and leaves extracts were identified by HPLC-UV/PAD analysis combined with ...
COLOMBO, Renata, LIRA, Tatiana O. de, VILA, Fabiana C., YARIWAKE, Janete H.   +3 more
core   +1 more source

Study of C- and O-glycosylflavones in sugarcane extracts using liquid chromatography: exact mass measurement mass spectrometry [PDF]

, 2008
The flavonoids present in sugarcane (Saccharum officinarum) extracts were analyzed by liquid chromatography - mass spectrometry (LC-MS), and a study of the fragmentation patterns of selected flavonoids was conducted using orthogonal acceleration time-of ...
COLOMBO, Renata, MCCULLAGH, Michael, YARIWAKE, Janete H.   +2 more
core   +1 more source

Diosmetin alleviates hypoxia‑induced myocardial apoptosis by inducing autophagy through AMPK activation

Molecular Medicine Reports, 2020
Diosmetin has shown great potential in the control of several diseases. The aim of the present study was to evaluate the role of diosmetin as a candidate agent for the treatment of myocardial infarction which was mainly caused by hypoxia. The model of hypoxia‑injured myocardial cells was established using the H9c2 cell line.
Si, Qijun, Shi, Yujie, Huang, Dandan, Zhang, Na   +3 more
openaire   +3 more sources

Diosmetin inhibits apoptosis and activates AMPK‐induced autophagy in myocardial damage under hypoxia environment

Kaohsiung Journal of Medical Sciences, 2022
Inhibition of hypoxia‐induced cardiomyocyte apoptosis is considered as an important treatment method for ischemic heart diseases, but related drugs are still insufficient. The present study aims to explore the protective function and mechanism of the key
Wen‐Shuai He, Yun Wu, Mao‐Jia Ren, Zhong‐Yu Yu, Xing‐Sheng Zhao   +4 more
doaj   +1 more source