ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL
eLife, 2020 Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL.
Gordana Wutz +19 more
doaj +1 more source
DNA Damage Response and Repair in Adaptive Immunity
Frontiers in Cell and Developmental Biology, 2022 The diversification of B-cell receptor (BCR), as well as its secreted product, antibody, is a hallmark of adaptive immunity, which has more specific roles in fighting against pathogens.
Sha Luo +4 more
doaj +1 more source
DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes [PDF]
, 2019 Cells possess remarkable control of the folding and entanglement topology of long and flexible chromosomal DNA molecules. It is thought that structural maintenance of chromosome (SMC) protein complexes play a crucial role in this, by organizing long DNAs
Marko, John +12 more
core +1 more source
Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils
, 2023 SUMMARY The Structural Maintenance of Chromosome (SMC) protein complexes cohesin, condensin and the Smc5/6 complex (Smc5/6) are essential for chromosome function. At the molecular level, these complexes fold DNA by loop extrusion.
Pradhan, B +9 more
core +1 more source
Anisotropic scrunching of SMC with a baton-pass mechanism
Communications BiologyDNA-loop extrusion is considered to be a universal principle of structural maintenance of chromosome (SMC) proteins with regard to chromosome organization.
Kyoung-Wook Moon +2 more
doaj +1 more source
Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells
Cell Reports, 2020 Summary: How chromosome organization is related to genome function remains poorly understood. Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression. Here,
James D.P. Rhodes +15 more
doaj +1 more source
Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms
Molecular Cell, 2022 Summary Cohesin connects CTCF binding sites and other genomic loci in cis to form chromatin loops, and replicated DNA molecules in trans to mediate sister chromatid cohesion.
Kota Nagasaka +10 more
openaire +2 more sources
Multi-scale phase separation by explosive percolation with single-chromatin loop resolution
Computational and Structural Biotechnology Journal, 2022 The 2 m-long human DNA is tightly intertwined into the cell nucleus of the size of 10 μm. The DNA packing is explained by folding of chromatin fiber.
Kaustav Sengupta +8 more
doaj +1 more source
Markovian Dynamics in Chromatin Loop Extrusion Factors [PDF]
, 2020 Markov properties can be used to model different dynamic processes at various stages of the loop extrusion process. The current methods are proposed to gain insight on how Markov models may illustrate chromatin behaviour once the appropriate observed ...
Eng, Kathleen
core
SMC complexes: Lifting the lid on loop extrusion.
, 2022 Loop extrusion has emerged as a prominent hypothesis for how SMC complexes shape chromosomes - single molecule in vitro observations have yielded fascinating images of this process.
Torahiko L Higashi (9219092) +1 more
core +1 more source