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Mitochondrial dynamics in cisplatin resistance: molecular mechanisms and therapeutic targeting. [PDF]
Front OncolHuang W, Sun W, Yang Z, Li Y, Wang Z.
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Drp1-dependent mitochondrial fission in cardiovascular disease
Acta Pharmacologica Sinica, 2020Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to modulate their morphology, distribution, and function, which are referred as 'mitochondrial dynamics'. Dynamin-related protein 1 (Drp1) is known as the major pro-fission protein whose activity is tightly regulated to clear the damaged mitochondria via mitophagy ...
Jia-Yu, Jin +4 more
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AMPK/Drp1 Pathway Mediates Streptococcus Uberis-Induced Mitochondrial Dysfunction
SSRN Electronic Journal, 2022Excessive production of reactive oxygen species (ROS) leads to oxidative stress in host cells and affects the progress of disease. Mitochondria are an important source of ROS and their dysfunction is closely related to ROS production. S. uberis is a common causative agent of mastitis. The expression of key enzymes of the mitochondrial apoptotic pathway
Yuanyuan, Zhou +6 more
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A novel cardioprotective function for DRP1 inhibition
Nature Reviews Cardiology, 2021A new study identifies a small-molecule inhibitor of a mitochondrial fission protein that reduces PCSK9 secretion and atherosclerotic plaque formation.
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Drp1-Zip1 Interaction Regulates Mitochondrial Quality Surveillance System [PDF]
Molecular Cell, 2019 Mitophagy, a mitochondrial quality control process for eliminating dysfunctional mitochondria, can be induced by a response of dynamin-related protein 1 (Drp1) to a reduction in mitochondrial membrane potential (MMP) and mitochondrial division. However, the coordination between MMP and mitochondrial division for selecting the damaged portion of the ...
Hyo Min Cho +2 more
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Abstract P3178: Gja1-20k Is Downstream Of Drp1 And Can Rescue Drp1 Suppression In Mouse Heart
Circulation Research, 2023Dynamin-Related Protein 1 (DRP1) is a major mediator of mitochondrial fission and its mutation results with hyper-fused mitochondria and, in mice, a dilated cardiomyopathy. GJA1-20k is the most abundant N-terminus truncated isoform of Connexin 43 (Cx43) formed by internal translation and was originally identified as a trafficking subunit of Cx43.
Jennifer Hunter +4 more
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Recruitment of Drp1 in Mitochondrial Fission
The FASEB Journal, 2017Intracellular membranes are dynamically shaped by proteins including fission and fusion events important for vesicular transport, organelle trafficking, and cellular homeostasis. Yet how proteins interact with membranes to control these events is largely unknown.
John M Egner +3 more
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Drp1 in Ischemic Neuronal Death: An Unusual Suspect
Current Medicinal Chemistry, 2014Mitochondria play a crucial role in multitude of cellular processes including energy production, calcium signaling, and apoptosis. This remarkable organelle constantly undergoes a complex cycle of fusion and fission, a crucial quality control system for maintaining homeostasis of the cell.
H, Pradeep, B, Sharma, G K, Rajanikant
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