Results 1 to 10 of about 74,293 (296)

Universal and quantitative detection of double-stranded RNAs as a signature of pan-virus infections using a luciferase-based biosensor [PDF]

Journal of Biological Engineering
Background Infections with various RNA viruses and certain DNA viruses may produce double-stranded RNA (dsRNA) during replication, which trigger host innate immune responses.
Michihito Sasaki, Eri Fujii, Satoko Sasaki, Takuma Ariizumi, Kei Konishi, Akihiko Sato, William W. Hall, Hirofumi Sawa, Yasuko Orba   +8 more
doaj   +2 more sources

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells

Nature Communications
The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, we report that the release of mt-dsRNA into the cytosol is a general feature of senescent cells and a ...
Vanessa López-Polo, Mate Maus, Emmanouil Zacharioudakis, Miguel Lafarga, Camille Stephan-Otto Attolini, Francisco D. M. Marques, Marta Kovatcheva, Evripidis Gavathiotis, Manuel Serrano   +8 more
doaj   +2 more sources

Double-stranded RNA antiviral signature in early multiple sclerosis [PDF]

Frontiers in Microbiology
IntroductionViruses, particularly Epstein–Barr virus (EBV), are strongly implicated in multiple sclerosis (MS) pathogenesis, yet reliable biomarkers of active viral replication remain limited.
Vasileios Gouzouasis, Vasileios Gouzouasis, Ioannis Sarrigeorgiou, Margaritis Tsifintaris, Nikos Markoglou, Urania Georgopoulou, Peggy Lymberi, Maria Anagnostouli, Lesley Probert, Antonis Giannakakis, Antonis Giannakakis   +10 more
doaj   +2 more sources

Application of Double-stranded RNA (dsRNA) Produced by E. coli HT115 (DE3) and Vector L4440 in Reverse Genetics Studies in Insects [PDF]

Journal of Genetic Resources, 2023
RNA interference is a cellular process for regulating gene expression by double-stranded RNA (dsRNA). In the past two decades, this cellular process has been used as a tool for the temporary knockdown of gene expression to study gene function in reverse ...
Roohollah Abbasi
doaj   +1 more source

Double-stranded RNAs are promising adjuvants for enhancing immunogenicity of vaccines

Журнал микробиологии, эпидемиологии и иммунобиологии, 2023
Background. The most effective way to prevent infectious diseases is vaccination. Adjuvants contribute to the optimization of the immune response of vaccines.
Olga N. Kaplina, Svetlana G. Gamaley, Olga S. Ivanova, Elena D. Danilenko   +3 more
doaj   +1 more source

The Functional Mechanisms of Toll-Like Receptor 3 and Its Implications in Digestive System Tumors

Frontiers in Bioscience-Landmark, 2023
Toll-like receptor 3 (TLR3) is a prominent member of the Toll-like receptor (TLR) family and has the ability to recognize and bind intracellular double-stranded RNA (dsRNA).
Bin Han, Chao Zhang, Xiaoxiao Wang, Huangqin Song, Lei Zhang, Tao Li, Jiefeng He, Haoliang Zhao   +7 more
doaj   +1 more source

Phenotype remodeling in neutrophilic granulocyte subsets CD64^-CD32⁺CD16⁺CD11B⁺NG, CD64⁺CD32⁺CD16⁺CD11B⁺NG in de novo experimental model of viral-bacterial infection in vitro

Инфекция и иммунитет, 2021
A search for new targeted therapeutic strategies based on examining immunopathogenetic mechanisms for emerging co-infections is relevant and may further contribute not only to optimizing choice of immunotropic drugs, but also to achieving positive ...
I. V. Nesterova, G. A. Chudilova, T. V. Rusinova, V. N. Pavlenko, Ya. A. Yutskevich, N. K. Barova, V. A. Tarakanov   +6 more
doaj   +1 more source

Artificial nanovesicles for dsRNA delivery in spray‐induced gene silencing for crop protection

Plant Biotechnology Journal, 2023
Summary Spray‐induced gene silencing (SIGS) is an innovative and eco‐friendly technology where topical application of pathogen gene‐targeting RNAs to plant material can enable disease control.
Lulu Qiao, Jonatan Niño-Sánchez, R. Hamby, L. Capriotti, Angel Y. S. Chen, B. Mezzetti, Hailing Jin   +6 more
semanticscholar   +1 more source

Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation

Science Advances, 2023
Deposition of tau protein aggregates in the brain of affected individuals is a defining feature of “tauopathies,” including Alzheimer’s disease.
Elizabeth Ochoa, Paulino Ramirez, Elias Gonzalez, Jasmine De Mange, William J Ray, Kevin F Bieniek, Bess Frost   +6 more
semanticscholar   +1 more source

Biological control of pathogenic fungi: Can mycoviruses play an important role? [PDF]

Journal of Central European Agriculture, 2022
In the past few years, huge economic and environmental losses have resulted by fungal pathogens in agriculture and food production worldwide. Fungal toxins also pose a threat for food production and animal health.
Tomáš Tonka, Lucie Walterová, Vladislav Čurn   +2 more
doaj   +1 more source