Results 91 to 100 of about 99,698 (261)
“More” Artificial mRNAs: Beyond the Art of Nature
Advanced Science, EarlyView.Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui +3 more
wiley +1 more source
Transcriptional control of behaviour: engrailed knockout changes cockroach escape trajectories [PDF]
, 2009 The cerci of the cockroach are covered with identified sensory hairs that detect air movements. The sensory neurons that innervate these hairs synapse with giant interneurons in the terminal ganglion that in turn synapse with interneurons and leg motor ...
Bacon, Jonathan P +4 more
core +1 more source
Advanced Science, EarlyView.In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu +9 more
wiley +1 more source
Drug Delivery, 2017 Our previous work proved that sequence specific double strand RNA (dsRNA-p21) effectively activated p21 gene expression of colorectal cancer (CRC) cells and consequently suppressed CRC growth. However, efficient delivery system is a significant challenge
Chen-Lin Feng +7 more
doaj +1 more source
Recognition of Double-Stranded RNA and Regulation of Interferon Pathway by Toll-Like Receptor 10
Frontiers in Immunology, 2018 Toll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of ...
Suki Man-Yan Lee +6 more
doaj +1 more source
Advanced Science, EarlyView.The RNA G‐quadruplexes formed at the 5'‐end of the RNA component of human telomerase possess extreme slow unfolding rate, rendering them resistant to nuclease degradation. The helicase DHX36 overcame this kinetic barrier and significantly reduced the folded fraction.
Qun Luo +5 more
wiley +1 more source
Gene silencing in tick cell lines using small interfering or long double-stranded RNA [PDF]
, 2012 Gene silencing by RNA interference (RNAi) is an important research tool in many areas of biology. To effectively harness the power of this technique in order to explore tick functional genomics and tick-microorganism interactions, optimised parameters ...
A-C Barnard +57 more
core +4 more sources
Targeting viral dsRNA for antiviral prophylaxis
The FASEB Journal, 2009 ABSTRACT Double‐stranded (ds)RNA in the infected cells is a trait shared by most if not all viruses. While humans have developed variable immune responses, viruses have also developed counter‐measures to defeat dsRNA‐induced antiviral strategies.
Zhou, Fei +5 more
openaire +3 more sources
BMEMat, EarlyView.This study develops a nano‐enzyme patch (ezPatch) targeting bone interfaces. Utilizing ligand‐to‐metal charge transfer (LMCT) catalysis and bone‐targeting ligands on copper nanosheets, ezPatch simultaneously scavenges reactive oxygen species (ROS) and generates oxygen in situ at bone‐losing sites.
Yi Chen +12 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2018 An important step in the initiation of the innate immune response to virus infection is the recognition of non-self, viral RNA, including double-stranded RNA (dsRNA), by cytoplasmic pattern recognition receptors (PRRs).
Elizabeth J. Mateer +2 more
doaj +1 more source