Results 151 to 160 of about 114,219 (358)

Phosphorylation of an RNA‐Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging

Aging Cell, EarlyView.
Evolutionary conserved Hippo/Mst1 signaling non‐canonically regulates the stability of mRNAs through directly phosphorylating a subset of RNA binding proteins to stabilize lipolytic mRNAs. Hpo pathway contributes to the regulation of Drosophila lifespan by modulating the expression and activity of Me31b/RCK, which subsequently affects mRNA levels of ...
Eunbyul Yeom, Hyejin Mun, Jinhwan Lim, Yoo Lim Chun, Kyung‐Won Min, Johana Lambert, L. Ashley Cowart, Jason S. Pierce, Besim Ogretmen, Jung‐Hyun Cho, Jeong Ho Chang, J. Ross Buchan, Jason Pitt, Matt Kaeberlein, Sung‐Ung Kang, Eun‐Soo Kwon, Seungbeom Ko, Kyoung‐Min Choi, Yong Sun Lee, Yoon‐Su Ha, Seung‐Jin Kim, Kwang‐Pyo Lee, Hyo‐Sung Kim, Seo Young Yang, Chang Hoon Shin, Je‐Hyun Yoon, Kyu‐Sun Lee   +26 more
wiley   +1 more source

Development of Biolayer Interferometry (BLI)-Based Double-Stranded RNA Detection Method with Application in mRNA-Based Therapeutics and Vaccines

Pharmaceutics
Background: In vitro-transcribed (IVT) mRNA has been established as a promising platform for therapeutics and vaccine development. Double-stranded RNA (dsRNA) is a major impurity of IVT mRNA and can trigger unfavored immune responses, potentially causing
Dharia Sara Silas, Bindiya Juneja, Keerat Kaur, Muralikrishna Narayanareddy Gari, Yingjian You, Youmi Moon, Yizhuo Chen, Srishti Arora, Johanna Hansen, Kathir Muthusamy, Yue Fu, Nisha Palackal, Erica A. Pyles   +12 more
doaj   +1 more source

HLH‐30/TFEB Rewires the Chaperone Network to Promote Proteostasis Upon Perturbations to the Coenzyme A and Iron–Sulfur Cluster Biosynthesis Pathways

Aging Cell, EarlyView.
Proteostasis enhancing treatments are potential therapies for many age‐related diseases. We discovered that interference with the CoA biosynthesis pathway and limiting iron‐sulfur cluster availability improve proteostasis in C. elegans. Proteostasis improvement under these conditions depends on the conserved HLH‐30/TFEB transcription factor, which ...
Rewayd Shalash, Dror Michael Solomon, Mor Levi‐Ferber, Henrik von Chrzanowski, Mohammad Khaled Atrash, Barak Nakar, Matan Yosef Avivi, Hagit Hauschner, Aviya Swisa, Alicia Meléndez, Yaron Shav‐Tal, Sivan Henis‐Korenblit   +11 more
wiley   +1 more source

Israeli acute paralysis virus infection leads to an enhanced RNA interference response and not its suppression in the bumblebee Bombus terrestris [PDF]

, 2016
RNA interference (RNAi) is the primary antiviral defense system in insects and its importance for pollinator health is indisputable. In this work, we examined the effect of Israeli acute paralysis virus (IAPV) infection on the RNAi process in the ...
Cappelle, Kaat, Dhaenens, Maarten, Meeus, Ivan, Smagghe, Guy   +3 more
core   +2 more sources

Method for the production of DSRNA

, 2019
Peer ...
Daròs Arnau, José Antonio, Ortolá Navarro, Beltrán, Cordero, María Teresa   +2 more
openaire   +2 more sources

The Proprotein Convertase BLI‐4 Is Required for Axenic Dietary Restriction Mediated Longevity in Caenorhabditis elegans

Aging Cell, EarlyView.
In ADR‐induced longevity in C. elegans, neuronal BLI‐4 processes neuropeptides, which are then released with the assistance of UNC‐31 and GOLG‐2. ABSTRACT Dietary restriction (DR) is a well‐established method for extending lifespan across various species, including C. elegans.
Ping Wu, Lieselot Vandemeulebroucke, Huaihan Cai, Bart P. Braeckman   +3 more
wiley   +1 more source

Generation of Virus- and dsRNA-Derived siRNAs with Species-Dependent Length in Insects

Viruses, 2019
Double-stranded RNA (dsRNA) molecules of viral origin trigger a post-transcriptional gene-silencing mechanism called RNA interference (RNAi). Specifically, virally derived dsRNA is recognized and cleaved by the enzyme Dicer2 into short interfering RNAs ...
D. Santos, Lina Mingels, Elise Vogel, Luoluo Wang, O. Christiaens, K. Cappelle, N. Wynant, Y. Gansemans, F. van Nieuwerburgh, G. Smagghe, L. Swevers, J. Vanden Broeck   +11 more
semanticscholar   +1 more source

ICTV Virus Taxonomy Profile: Chrysoviridae [PDF]

, 2018
The Chrysoviridae is a family of small, isometric, non-enveloped viruses (40 nm in diameter) with segmented dsRNA genomes (typically four segments). The genome segments are individually encapsidated and together comprise 11.5–12.8 kbp.
Bradley I. Hillman, Dae-Hyun Kim, Daohong Jiang, Ghabrial, Hiromitsu Moriyama, José R. Castón, Robert H. A. Coutts, Said A. Ghabrial   +7 more
core   +2 more sources

Differential utilization of NF-kappaB RELA and RELB in response to extracellular versus intracellular polyIC stimulation in HT1080 cells

BMC Immunology, 2011
Background Pattern recognition receptors (PRRs) for double-stranded RNA (dsRNA) are components of innate immunity that recognize the presence of viral infection and initiate efficient defense mechanisms.
Tsao Ming-Sound, Yun James J, Der Sandy D   +2 more
doaj   +1 more source

Metformin and Dietary Restriction Counteract Aging via Reducing m6A–Dependent Stabilization of Methionine Synthase mRNA in Brachionus asplanchnoidis (Rotifera)

Aging Cell, EarlyView.
Metformin and dietary restriction modulate m6A to extend lifespan of rotifer, highlighting MTR as a central regulator of aging through methionine metabolism. ABSTRACT Metformin, a medication primarily used to treat diabetes, has gained attentions for its potential antiaging properties.
Yu Zhang, Xiaojie Liu, Hairong Lian, Yanchao Chai, Yang Zhou, Dongqi Kan, Jilong Ren, Cui Han, Jiaxin Yang   +8 more
wiley   +1 more source